1,375 results match your criteria: "Hospital Universitario 'San Cecilio'[Affiliation]"

Article Synopsis
  • Patch test outcomes can be affected by age, but there are mixed findings on how age impacts these results.
  • The study involved over 13,000 patients and revealed that middle-aged adults (31-65 years) had the highest rates of positive skin sensitisation results, particularly for certain substances like nickel and potassium dichromate.
  • Overall, while age does influence some patch test results, most allergens showed consistent reactivity across ages, underscoring the importance of standard testing regardless of age.
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Article Synopsis
  • * The MEASURE-AD trial was conducted to gather comprehensive data on the burden of AD, using both patient and physician feedback, focusing on adults with moderate-to-severe cases.
  • * Results from the Spanish cohort revealed that patients with higher disease severity (EASI scores 21.1-72) experienced greater symptom burden, mental health issues, reduced quality of life, increased healthcare usage, and higher out-of-pocket costs compared to those with lower severity scores.
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Nutritional and potential health benefits of chufa oil, olive oil, and anhydrous milk fat against gallstone disease in a C57BL/6N mouse model.

Front Nutr

September 2024

Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Córdoba, Córdoba, Spain.

Article Synopsis
  • Dietary lipids, including plant oils, have significant implications on heart health and diseases like cardiovascular issues, but there's limited research on specific oils like chufa oil, olive oil, and anhydrous milk fat (AMF) in relation to atherosclerosis in mice.
  • In a study with 4-week-old C57BL/6N male mice, those fed with AMF had the highest occurrence of gallstones (85.7%), while chufa oil resulted in the lowest gallstone formation (42.9%) and reduced serum cholesterol levels.
  • Despite differences in food intake, body weight remained unchanged across groups, and chufa oil demonstrated benefits for cholesterol metabolism without harmful nutritional effects, although gallstone formation was a common
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Article Synopsis
  • - In 2017, the Spanish Academy of Dermatology created the Minimal Disease Activity (MDA) criteria to assess psoriasis severity, and this study aimed to evaluate its nationwide application across Spain.
  • - The study included 830 psoriasis patients, showing that over 59% did not meet MDA criteria, with significant variances observed based on region, sex, age, and treatment type.
  • - Results indicated that patients using biological therapies had better MDA compliance compared to those on other treatments, suggesting a need for more effective management of psoriasis across different demographics.
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Exposure to bisphenols, parabens, and benzophenones in colostrum breast milk of Panamanian women: A pilot study from the PA-MAMI cohort.

Sci Total Environ

December 2024

Instituto de Investigación Biosanitaria de Granada (ibs. GRANADA), E-18012 Granada. Spain. Electronic address:

Article Synopsis
  • This study investigates the presence of non-persistent endocrine-disrupting chemicals (EDCs), including bisphenols, parabens, and benzophenones, in the colostrum of Panamanian mothers to understand their breastfeeding influences.
  • Results showed that all colostrum samples contained multiple EDCs, with bisphenol A (BPA) being the most common at a detection rate of 91.7%, highlighting potential environmental exposures.
  • The analysis also indicated that factors such as maternal residence, diet, and personal care products influenced EDC concentrations, suggesting the need for preventive measures to ensure safe breastfeeding practices.
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[Translated article] Management of spinal deformities caused by osteoporotic vertebral fractures.

Rev Esp Cir Ortop Traumatol

October 2024

Unidad de Patología de Columna, Servicio de Traumatología, Fundación Jiménez Díaz, Madrid, Spain.

Article Synopsis
  • - Osteoporosis and fragility significantly affect how patients with deformities from osteoporotic vertebral fractures (OVF) are treated, posing challenges for both medical and surgical management.
  • - There is a growing need for a specific classification system for these deformities, which could be enhanced by artificial intelligence and machine learning for better predictive analysis in treatment planning.
  • - The approach emphasizes personalized treatment solutions focusing on preoperative optimization, with a recommendation for minimally invasive techniques to improve recovery and minimize complications.
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Article Synopsis
  • Cetuximab, a therapeutic monoclonal antibody used in cancer treatment, lacks sufficient data regarding risks of mishandling in hospital environments, prompting a need for studies on its stability under various stress conditions.* -
  • The study evaluated the impact of factors like light exposure, temperature fluctuations, and agitation on cetuximab's physical and functional properties, using advanced analytical techniques to assess its quality attributes.* -
  • Findings indicated that light exposure caused significant degradation of cetuximab, leading to harmful changes in its structure and effectiveness, suggesting that the drug should be protected from such conditions to maintain its safety and efficacy.*
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Article Synopsis
  • * In a group of 13 patients who underwent revision surgery after using ceramics, assessments showed that despite appearances of fusion on imaging, actual solid fusion was lacking according to surgical and histological evaluations.
  • * Findings indicated that biphasic ceramics did not integrate well with bone, with evidence of incomplete resorption and replacement by immature tissue, suggesting that their use should be approached with caution.
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Multiomic-based immune response profiling in migraine, vestibular migraine and Meniere's disease.

Immunology

December 2024

Meniere Disease Neuroscience Research Program, Faculty of Medicine and Health, School of Medical Sciences, The Kolling Institute, University of Sydney, Sydney, New South Wales, Australia.

Article Synopsis
  • Migraines (MI) are a common brain problem affecting about 20% of people worldwide, and some people with migraines also have balance issues, which is called vestibular migraine (VM).
  • Meniere's disease (MD) is another condition that affects the inner ear and can cause spinning sensations, ringing in the ears, and hearing loss, which sometimes overlaps with vestibular migraine symptoms.
  • A study compared blood samples from people with migraines, vestibular migraines, Meniere's disease, and healthy individuals, finding that migraines and vestibular migraines have similar immune responses, while Meniere's disease shows different immune reactions and can be divided into two types based on activity.
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Long-term benefit of ustekinumab in ulcerative colitis in clinical practice: ULISES study.

Aliment Pharmacol Ther

November 2024

Gastrointestinal Units of Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.

Article Synopsis
  • Ustekinumab is approved for treating ulcerative colitis (UC), and this study evaluated its long-term effectiveness and tolerability in real clinical settings.
  • In a multicenter analysis of 620 UC patients, 25% discontinued treatment, with baseline anemia, steroid use, and severe disease linked to higher discontinuation rates.
  • At 16 weeks, 40% of patients were in steroid-free remission, and treatment was generally safe with no adverse effects on other conditions, indicating good long-term durability for difficult-to-treat cases.
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Correction: A systematic review on the contribution of DNA methylation to hearing loss.

Clin Epigenetics

September 2024

Meniere's Disease Neuroscience Research Program, Faculty of Medicine and Health, School of Medical Sciences, The Kolling Institute, University of Sydney, Rm 611024, Level 11 Kolling Institute | 10 Westbourne St, St Leonards, Sydney, NSW, 2064, Australia.

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Snapshot of knowledge and stigma toward mental health disorders and treatment in Spain.

Front Psychol

August 2024

Deparment of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcala, Alcala de Henares, Spain.

Background: Mental disorders significantly impact individuals and societies globally. Addressing societal stigma is crucial, as it affects help-seeking behaviors and the effectiveness of treatment for mental disorders.

Objective: This study aims to explore the knowledge and perceptions of the Spanish population toward mental disorders and their treatment, assess changes in mental health stigma over time, and examine variations across sociodemographic variables by comparing current results with previous studies.

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Introduction: A clinical dermatological research was conducted in Spain from 2005 through 2014 as part of the MaIND project with the provinces or centers with the highest number of published articles. However, a low level of evidence in scientific production was confirmed as the overall result. The aim of this study is to update the Spanish clinical dermatological research in bibliometric terms from 2015 through 2021 with comparisons between both periods of time.

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Article Synopsis
  • Recent years have seen a rise in the approval of monoclonal antibodies (mAbs) and other biological treatments, each with varied immunosuppressive effects and mechanisms that necessitate personalized vaccination schedules for patients.
  • Current vaccine recommendations for patients on mAbs are mainly based on expert opinions rather than individualized protocols, highlighting a significant gap in research addressing the diverse uses of these treatments.
  • This review aims to compile information on mAbs approved by the EMA as of January 1, 2024, and provide a practical guide for personalizing vaccination strategies for immunocompromised individuals, reflecting recent developments in vaccine technology and administration practices.
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Management of Spinal Deformities Caused by Osteoporotic Vertebral Fractures.

Rev Esp Cir Ortop Traumatol

September 2024

Unidad de Patología de Columna, Servicio de Traumatología, Fundación Jiménez Díaz, Madrid, España.

Osteoporosis and fragility play a significant role in the treatment and planning of patients with deformity secondary to osteoporotic vertebral fracture (OVF). The resulting deformity can present significant challenges for its management, both from a medical and surgical perspective. The need for a specific classification for these deformities, including the potential for the development of artificial intelligence and machine learning in predictive analysis, is emerging as a key point in the coming years.

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Background: The objectives were to evaluate the safety and immunogenicity of the nonavalent human papillomavirus (nHPV) vaccine in adult Spanish women living with HIV (WLHIV); the prevalence of anal and cervical dysplasia and nHPV vaccine genotypes in the anus and cervix; and risk factors for high-risk HPV (HR-HPV) infection in anal mucosa.

Methods: In this single-center, open-arm, non-randomized clinical trial, the nHPV vaccine was administered at 0, 2, and 6 months to WLHIV enrolled between February 2020 and November 2023, measuring vaccine antibody titers pre-vaccination and at 2, 6, and 7 months after the first dose. Cervical and anal cytology and HPV PCR genotyping studies were performed.

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Introduction And Objectives: Management in recent-onset atrial fibrillation (AF) is to achieve sinus rhythm (SR) by cardioversion (CV). However, frequently SR is spontaneously restored, making scheduled admission unnecessary and causing misutilization of healthcare resources. Emerging medical technology allows accurate heart rhythm monitoring.

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Article Synopsis
  • Diffuse alveolar hemorrhage (DAH) is a severe and uncommon complication in systemic lupus erythematosus (SLE) patients, with early diagnosis and treatment critical for improving survival rates.
  • In a study from the RELESSER register, 37 out of 4024 SLE patients experienced DAH, with notable characteristics including a high prevalence of women and links to renal issues and thrombocytopenia.
  • Factors associated with higher mortality in DAH patients included smoking, prior lupus nephritis, infections, and the use of cyclophosphamide, with a mortality rate of 35.7% observed in the cohort.
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Co-morbid sarcopenia and low bone mineral density in young paediatric cancer survivors.

J Cachexia Sarcopenia Muscle

October 2024

Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.

Background: Sarcopenia and low areal bone mineral density (aBMD) are prevalent musculoskeletal complications after paediatric cancer treatment. However, their relationship has not been examined in young paediatric cancers survivors. This study aimed to evaluate aBMD differences according to sarcopenia status and the risk of low aBMD Z-score in young paediatric cancer survivors with sarcopenia confirmed/probable.

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The One Health approach, recognizing the interconnectedness of human, animal, and environmental health, has gained significance amid emerging zoonotic diseases and antibiotic resistance concerns. This paper aims to demonstrate the utility of a collaborative tool, the SIEGA, for monitoring infectious diseases across domains, fostering a comprehensive understanding of disease dynamics and risk factors, highlighting the pivotal role of One Health surveillance systems. Raw whole-genome sequencing is processed through different species-specific open software that additionally reports the presence of genes associated to anti-microbial resistances and virulence.

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Update on the pathophysiology, diagnosis and management of Ménière's disease.

Curr Opin Otolaryngol Head Neck Surg

October 2024

Division of Otolaryngology, Department of Surgery, Instituto de Investigación Biosanitaria, ibs.GRANADA, Granada, Universidad de Granada, Granada, Spain.

Purpose Of Review: The aim of this work is to summarize the main advances on the pathophysiology, diagnosis, and treatment of Meniere's disease (MD).

Recent Findings: Different immune responses to biotic stimuli may trigger MD, with subgroups identified based on cytokine and genetic profile, suggesting potential benefits from immune therapy, including antiallergic medication. Genetic and epigenetic research, along with imaging studies, reveal the complexity of MD, involving inflammation, immunity, and metabolic processes.

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