7,112 results match your criteria: "Hospital Universitario '12 de Octubre'.[Affiliation]"
Assessment of PD-L1 expression and tumour infiltrating lymphocytes in early-stage non-small cell lung carcinoma with artificial intelligence algorithms.
J Clin Pathol
October 2024
Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain.
Aims: To study programmed death ligand 1 (PD-L1) expression and tumour infiltrating lymphocytes (TILs) in patients with early-stage non-small cell lung carcinoma (NSCLC) with artificial intelligence (AI) algorithms.
Methods: The study included samples from 50 early-stage NSCLCs. PD-L1 immunohistochemistry (IHC) stained slides (clone SP263) were scored manually and with two different AI tools (PathAI and Navify Digital Pathology) by three pathologists.
Developing a sustainable team in critical care: focus on gender-based diversity.
Anaesth Crit Care Pain Med
December 2024
Formation, Recherche, Evaluation (FOREVA), CHU Nîmes, Nîmes, CHU Reims, Unité de Médecine Intensive et Réanimation Polyvalente, Université de Reims Champagne-Ardenne, Unité HERVI "Hémostase et Remodelage Vasculaire Post-Ischémie" - EA 3801, F-51100 Reims, France. Electronic address:
Impact of the COVID-19 Pandemic on Pediatric Bacterial Community-Acquired Pneumonia: A Multicenter Retrospective Study in Madrid (Spain).
Pediatr Infect Dis J
October 2024
CIBER en Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.
This study conducted in Madrid (Spain) between 2018 and 2023 shows a significant decrease in the pediatric bacterial community-acquired pneumonia cases during the COVID-19 pandemic, followed by a notable postpandemic increase surpassing prepandemic incidence. Streptococcus pneumoniae remains predominant, with an increasing prevalence of serotype 3, while Streptococcus pyogenes was the second most common pathogen.
View Article and Find Full Text PDFLung cancer research and treatment: global perspectives and strategic calls to action.
Ann Oncol
December 2024
Icahn School of Medicine, Center for Thoracic Oncology, Tisch Cancer Institute at Mount Sinai, New York, USA. Electronic address:
Article Synopsis
- Lung cancer is a significant public health challenge with ongoing difficulties in prevention, diagnosis, and treatment, prompting a review of current research and management strategies.
- Experts from various fields collaborated to discuss ways to enhance lung cancer care, emphasizing the importance of tobacco cessation, early detection, and addressing treatment side effects.
- Effective lung cancer management requires global cooperation, better education, improved access to care and trials, and a focus on personalized treatment through innovative research.
Risk factors for poor outcome in adult patients with respiratory syncytial virus infection evaluated at the emergency department.
J Med Virol
October 2024
Unit of Infectious Diseases, Hospital Unversitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.
Article Synopsis
- Respiratory syncytial virus-associated acute respiratory infection (RSV-ARI) is increasingly affecting adults, leading to serious health issues, as shown in a study of 275 hospitalized patients.
- In this study, 11.2% of patients experienced poor outcomes, with certain factors increasing their risk, such as cognitive impairment, use of anticoagulants, and low oxygen saturation ratios upon hospital admission.
- Interestingly, receiving the flu vaccine in the current season was found to reduce the risk of poor outcomes, underscoring the importance of early risk assessment for RSV-ARI in the emergency department.
Muscle-Invasive Bladder Cancer in Non-Curative Patients: A Study on Survival and Palliative Care Needs.
Cancers (Basel)
September 2024
Department of Urology, Hospital Universitario 12 de Octubre, Avenida de Córdoba s/n, 28041 Madrid, Spain.
Objective: To assess the survival outcomes of patients diagnosed with muscle-invasive bladder cancer (MIBC) who are not candidates for curative treatment and to identify the factors influencing these outcomes.
Methods: We conducted an analysis of patients diagnosed with MIBC who were either unable or unwilling to undergo curative therapy. We evaluated overall survival (OS) and cancer-specific survival (CSS) and examined their associations with various clinical variables.
ANKK1 Is a Wnt/PCP Scaffold Protein for Neural F-ACTIN Assembly.
Int J Mol Sci
October 2024
Laboratory of Neurogenetics and Molecular Medicine, Center for Genomic Sciences in Medicine, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
Article Synopsis
- The IA polymorphism is linked to both the Ankyrin Repeat and Kinase Domain-containing I gene (ANKK1) and the D2 dopamine receptor gene, posing challenges in understanding its role in addictions and psychiatric disorders due to unclear ANKK1 functions.
- Research using SH-SY5Y neuroblastoma models shows that ANKK1 interacts with FARP1, a synapse protein, contributing to neuronal maturation and the activation of the Wnt/PCP pathway while promoting neuritogenesis.
- Interactions between ANKK1 and WGEF are crucial for regulating RhoGTPases during neuronal differentiation, indicating that ANKK1 may play a significant role in organizing the brain's structural response related to IA-associated
Concordance in the estimation of tumor percentage in non-small cell lung cancer using digital pathology.
Sci Rep
October 2024
Department of Pathology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034, Madrid, Spain.
Article Synopsis
- The study investigated the reliability of pathologists in quantifying tumor percentages in whole slide images (WSI) of non-small cell lung cancer (NSCLC) using digital image analysis after training them with QuPath.
- Initial assessments showed poor reliability among pathologists, with a low intraclass correlation coefficient (ICC) of 0.09, which only slightly improved to an ICC of 0.24 in a follow-up trial after receiving feedback.
- The research indicated that errors were mainly due to subjective tasks like annotation, and suggested that future AI technologies could enhance accuracy in digital pathology assessments.
Perinatal management and follow-up in a child with a prenatal diagnosis of OTC deficiency: a case report.
Front Nutr
September 2024
Centro de Referencia Nacional (CSUR) y Europeo (MetabERN) en Enfermedades Metabólicas, Hospital Universitario 12 de Octubre, Instituto de Investigación i+12, CIBERER, Madrid, Spain.
Ornithine transcarbamylase deficiency (OTCD) is the most common disorder of the urea cycle and is caused by a mutation of the gene, located on chromosome X. Its prevalence is estimated at 1 in 80,000 to 56,500 births, but this X-chromosomal inheritance results in males being more affected than females. In neonates affected with this disorder, hyperammonemia after birth can lead to neurological and liver damage that can be fatal.
View Article and Find Full Text PDFCurrent Management of Head and Neck Paragangliomas: A Multicenter Series With Long-Term Follow-Up.
Otolaryngol Head Neck Surg
January 2025
Endocrinology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
Article Synopsis
- - The study analyzed 202 patients with head and neck paragangliomas (HN-PGL) across 16 Spanish hospitals, noting that 67.8% of participants were women, with a mean age of 53.1 years and 264 tumors examined, primarily located in the carotid body.
- - Among patients, 20.8% had multiple tumors and 4% had metastatic disease; genetic testing revealed a pathogenic variant in SDHx in half of those tested, which was linked to younger patients and more complex tumor profiles.
- - The results showed that while surgery was the most common treatment, radiotherapy and observation (monitoring without active treatment) were also effective, and long-term survival rates remained high
Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum.
Kidney Int
December 2024
Division of Pediatric Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address:
Article Synopsis
- The haemolytic uraemic syndromes (HUS) include various conditions, with some linked to complement activation (CaHUS).
- The 2023 International Society of Nephrology HUS Forum featured experts discussing the latest knowledge, uncertainties, and proposed solutions in diagnosing and managing HUS.
- Key areas needing research include naming conventions, complement testing, identifying biomarkers, genetic factors for aHUS, treatment strategies for C5 inhibitors, and improving access to care for patients.
Gender Disparities on the Use and Outcomes of Mechanical Circulatory Support in Patients With Cardiogenic Shock Complicating Acute Myocardial Infarction.
Am J Cardiol
December 2024
Department of Cardiology, Hospital Universitario 12 de Octubre. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), CIBERCV, Madrid, Spain.
Article Synopsis
- Cardiogenic shock (AMI-CS) is a severe condition following acute myocardial infarction, showing high rates of morbidity and mortality, especially highlighting ongoing gender disparities in treatment.* -
- A study analyzing data from 151,560 AMI-CS patients found that women were significantly less likely to receive mechanical circulatory support (MCS) and had higher in-hospital mortality rates than men, despite no major differences in bleeding or other complications.* -
- Racial disparities were noted, with female patients from all racial backgrounds receiving less MCS than their male counterparts, while Black and Hispanic patients had lower MCS utilization compared to White patients, emphasizing the complexities of gender, race, and healthcare access.*
Avatrombopag in immune thrombocytopenia: A real-world study of the Spanish ITP Group (GEPTI).
Am J Hematol
December 2024
Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla, IBiS/CSIC, Universidad de Sevilla, Sevilla, Spain.
Article Synopsis
- Avatrombopag is a newly approved treatment for immune thrombocytopenia (ITP), with limited real-world effectiveness and safety data available.
- A study by the Spanish ITP Group involving 268 patients showed that 90.1% of those with low platelet counts improved significantly after starting the drug, with many achieving stable platelet levels.
- The treatment allowed most patients to reduce or stop corticosteroid use, and only a small percentage experienced thrombocytosis or thromboembolic events, indicating its potential as an effective management option for ITP.
Management of Patients with Advanced Prostate Cancer. Report from the 2024 Advanced Prostate Cancer Consensus Conference (APCCC).
Eur Urol
October 2024
Onkozentrum Zurich, University of Zurich and Tumorzentrum Hirslanden Zurich, Zurich, Switzerland.
Article Synopsis
- Innovations in advanced prostate cancer have improved outcomes, but there's still a lack of high-level evidence in clinical management, prompting the 2024 Advanced Prostate Cancer Consensus Conference to survey experts for insights.
- A panel of 120 international experts developed and voted on 183 consensus questions through a web-based survey prior to the conference, defining consensus as ≥75% agreement.
- The voting results highlight areas of agreement and disagreement that can guide clinical decisions and future research, with a focus on individualizing treatment based on patient characteristics and encouraging participation in clinical trials.
Mechanical circulatory support in cardiogenic shock patients.
Med Intensiva (Engl Ed)
December 2024
Department of Intensive Care Medicine, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
Article Synopsis
- Cardiogenic shock (CS) is a serious medical condition that requires quick intervention to address its cause and provide support for blood circulation.* -
- Mechanical circulatory support (MCS) is often used for patients with severe CS to replace ineffective heart function and prevent multiple organ failure, with different devices available for short or intermediate durations.* -
- Effective management of patients with MCS involves careful monitoring for complications and following structured protocols for device use and discontinuation.*
Impact of left ventricular unloading on postheart transplantation outcomes in patients bridged with VA-ECMO.
Rev Esp Cardiol (Engl Ed)
October 2024
Servicio de Cardiología, Complejo Hospitalario Universitario de A Coruña (CHUAC), Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Facultad de Ciencias de la Salud, Universidad de A Coruña, A Coruña, Spain.
Article Synopsis
- * A total of 245 patients were analyzed, with 54.3% using mechanical LV unloading techniques, primarily the intra-aortic balloon pump, showing an improved 1-year survival rate of 74.4% compared to 59.8% in those without LV unloading.
- * The findings suggest that preoperative LV unloading is linked to better survival rates after a year post-transplant, with no notable differences in other postoperative complications between groups.
CureMate: A clinical decision support system for breast cancer treatment.
Int J Med Inform
December 2024
Biomedical Engineering and Telemedicine Centre, ETSI Telecomunicación, Center for Biomedical Technology, Universidad Politécnica de Madrid, Avenida Complutense 30, 28040 Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre (imas12), Hospital Universitario 12 de Octubre, 28041 Madrid, Spain; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Calle de Melchor Fernández Almagro 3, 28029 Madrid, Spain. Electronic address:
Background: Breast Cancer (BC) poses significant challenges in treatment decision-making. Multiple first treatment lines are currently available, determined by several patient-specific factors that need to be considered in the decision-making process.
Purpose: To present CureMate, a Clinical Decision Support System to predict the most effective initial treatment for BC patients.
Nocardia and mucoral co-infection in heart transplant recipient.
Rev Esp Quimioter
December 2024
Marina Fayos, Hospital Universitario 12 de Octubre. Madrid. Av. Cordoba, s/n, Usera, 28041. Madrid, Spain.
Efficacy of Bismuth Therapy in Eradicating Helicobacter pylori in Children-Data From the RENIHp Registry.
Helicobacter
October 2024
Pediatric Gastroenterology Unit, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.
Article Synopsis
- The study aimed to evaluate the effectiveness of colloidal bismuth subcitrate (CBS) in eliminating H. pylori infections in children aged 5-18, using data from a national pediatric registry.
- Out of 682 patients in the registry, 38 were treated with CBS, and 93.8% of those treated successfully eradicated the infection, showing better results compared to non-CBS treatments.
- The findings indicate that CBS therapies can be highly effective even in patients with prior unsuccessful treatments, although they were used in a limited scope and at lower-than-ideal dosages.
Venovenous ECMO Weaning Failure. Utilization of Extracorporeal CO Removal (ECCOR) as a Bridge Therapy in ECMO Weaning: A Case Report.
Arch Bronconeumol
September 2024
Department of Critical Care Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
Reply to P. de Boissieu et al.
J Clin Oncol
January 2025
David R. Spigel, MD, Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN; Afshin Dowlati, MD, University Hospitals Seidman Cancer Center and Case Western Reserve University Cleveland, OH; Yuanbin Chen, MD, Cancer and Hematology Centers of Western Michigan, Grand Rapids, MI; Alejandro Navarro, MD, Hospital Universitario Vall d'Hebron and Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain; James Chih-Hsin Yang, MD, National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei, Taiwan; Goran Stojanovic, MD, Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia; Maria Jove, MD, PhD, Institut Català d'Oncologia Hospital Duran i Reynals, Barcelona, Spain; Patricia Rich, MD, Southeastern Regional Medical Center, Newnan, GA; Zoran G. Andric, MD, University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia; Yi-Long Wu, MD, Guangdong Lung Cancer Institute, Guangzhou, China; Charles M. Rudin, MD PhD, Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY; Huanyu Chen, PhD, Ipsen, Cambridge, MA; Li Zhang, MPH, Ipsen, Cambridge, MA; Stanley Yeung, PharmD, Ipsen, Cambridge, MA; Fawzi Benzaghou, MD, Ipsen, Cambridge, MA; Luis Paz-Ares, MD, Hospital Universitario 12 de Octubre, H120-CNIO Lung Cancer Unit, Universidad Complutense and Ciberonc, Madrid, Spain; and Paul A. Bunn, MD, University of Colorado School of Medicine, Aurora, CO.
Antiviral Treatment and Risk of Hearing Loss in Asymptomatic and Mild Symptomatic Infants With Congenital Cytomegalovirus.
Pediatr Infect Dis J
October 2024
From the Pediatric Infectious Diseases Unit, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain.
Article Synopsis
- The study aimed to evaluate hearing outcomes at 24 months for infants with mild congenital cytomegalovirus (cCMV) infection, comparing those who received antiviral treatment to those who did not.
- Utilizing data from the European Registry of Children with cCMV, researchers included infants diagnosed with cCMV early in life, who had normal physical exams and mild imaging findings.
- Results showed that 34.7% of the 196 participants received antiviral treatment, but there was no significant difference in hearing loss prevalence between treated (4.6%) and untreated groups (6.3%) after two years.
Testicular large B-cell lymphoma is genetically similar to PCNSL and distinct from nodal DLBCL.
Hemasphere
October 2024
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain.
Article Synopsis
- * A study involving 61 TLBCL patients analyzed their genetic characteristics compared to nodal DLBCL and primary CNS large B-cell lymphomas; findings indicated that TLBCL has fewer copy number changes but more somatic mutations than nodal DLBCL.
- * The results highlight a unique genetic profile for TLBCL, with most cases classified as MCD, indicating genetic diversity, suggesting that this lymphoma type warrants targeted treatment strategies due to its distinct biology.
Application of the Clinical Outcomes, Healthcare Resource Utilization, and Related Costs Model in Chronic Obstructive Pulmonary Disease Patients.
Respiration
October 2024
Faculty of Medicine, Universidad Complutense, Madrid, Spain.
Article Synopsis
- The study assessed outcomes, resource use, and costs related to Chronic Obstructive Pulmonary Disease (COPD) by analyzing a cohort of patients who visited the emergency department in 2018.
- In a sample of 2,384 COPD patients, the study found high mortality rates—23.4% within one year—and significant readmission rates, with costs totaling approximately €14.6 million.
- The findings highlight the need for specialized programs to improve care for COPD patients due to their high mortality, readmission rates, and substantial economic burden on the healthcare system.