37 results match your criteria: "Hospital Universitari de Bellvitge HUB[Affiliation]"

Article Synopsis
  • Researchers studied how changes in DNA (called epigenetic modifications) affect a type of cancer called Ewing sarcoma.
  • They found many genes in Ewing sarcoma with different levels of DNA methylation compared to healthy tissues, which could lead to tumor growth.
  • One important gene, PTRF, was found to help fight the cancer when added back into the Ewing sarcoma cells, helping to trigger cell death in the cancer cells.
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Apo AIV and Citrulline Plasma Concentrations in Short Bowel Syndrome Patients: The Influence of Short Bowel Anatomy.

PLoS One

September 2016

Unitat de Nutrició i Dietètica, Servei d'Endocrinologia i Nutrició, Hospital Universitari de Bellvitge (HUB), IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.

Introduction: Parenteral nutrition (PN) dependence in short bowel syndrome (SBS) patients is linked to the functionality of the remnant small bowel (RSB). Patients may wean off PN following a period of intestinal adaptation that restores this functionality. Currently, plasma citrulline is the standard biomarker for monitoring intestinal functionality and adaptation.

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Novel word acquisition in aphasia: Facing the word-referent ambiguity of natural language learning contexts.

Cortex

June 2016

Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; Department of Basic Psychology, Campus Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats, ICREA, Barcelona, Spain. Electronic address:

Recent research suggests that some people with aphasia preserve some ability to learn novel words and to retain them in the long-term. However, this novel word learning ability has been studied only in the context of single word-picture pairings. We examined the ability of people with chronic aphasia to learn novel words using a paradigm that presents new word forms together with a limited set of different possible visual referents and requires the identification of the correct word-object associations on the basis of online feedback.

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Music supported therapy promotes motor plasticity in individuals with chronic stroke.

Brain Imaging Behav

December 2016

Cognition and Brain Plasticity Group [Bellvitge Biomedical Research Institute] IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08097, Spain.

Novel rehabilitation interventions have improved motor recovery by induction of neural plasticity in individuals with stroke. Of these, Music-supported therapy (MST) is based on music training designed to restore motor deficits. Music training requires multimodal processing, involving the integration and co-operation of visual, motor, auditory, affective and cognitive systems.

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Electrical stimulation mapping of nouns and verbs in Broca's area.

Brain Lang

September 2015

Cognition and Brain Plasticity Group [Bellvitge Biomedical Research Institute-] IDIBELL, L'Hospitalet de Llobregat, Barcelona 08097, Spain; Dept. of Basic Psychology, Campus Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona 08097, Spain; Catalan Institution for Research and Advanced Studies, ICREA, Barcelona, Spain.

Electric stimulation mapping (ESM) is frequently used during brain surgery to localise higher cognitive functions to avoid post-chirurgical disabilities. Experiments with brain imaging techniques and neuropsychological studies showed differences in the cortical representation and processing of nouns and verbs. The goal of the present study was to investigate whether electric stimulation in specific sites in the frontal cortex disrupted noun and verb production selectively.

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Interhemispheric microstructural connectivity in bitemporal lobe epilepsy with hippocampal sclerosis.

Cortex

June 2015

Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet (Barcelona), Spain; Department of Basic Psychology, Campus Bellvitge, University of Barcelona, L'Hospitalet (Barcelona), Spain; Catalan Institution for Research and Advanced Studies, ICREA, Barcelona, Spain. Electronic address:

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. The most frequent pathologic finding in this condition is hippocampal sclerosis (HS). In addition, in a small proportion (14-23%) of refractory TLE patients, the presence of HS is bilateral.

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Unlabelled: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease which has no cure, so the treatment will be symptomatic in a Multidisciplinary Unit. It is composed of professionals, experts in patient care, with an interdisciplinary vision in order to act in a coordinated manner depending on the different situations which may arise over the course of the disease. There are several studies showing improved survival in patients treated within the framework of a multidisciplinary team compared to treatment by isolated specialties.

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Studying memory encoding to promote reliable engagement of the medial temporal lobe at the single-subject level.

PLoS One

April 2016

Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; Department of Basic Psychology, Bellvitge Campus, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain; Catalan Institution for Research and Advanced Studies, ICREA, Barcelona, Spain.

The medial temporal lobe (MTL)—comprising hippocampus and the surrounding neocortical regions—is a targeted brain area sensitive to several neurological diseases. Although functional magnetic resonance imaging (fMRI) has been widely used to assess brain functional abnormalities, detecting MTL activation has been technically challenging. The aim of our study was to provide an fMRI paradigm that reliably activates MTL regions at the individual level, thus providing a useful tool for future research in clinical memory-related studies.

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Morphological derivation overflow as a result of disruption of the left frontal aslant white matter tract.

Brain Lang

March 2015

Cognition and Brain Plasticity Group [Bellvitge Biomedical Research Institute - IDIBELL], 08097 L'Hospitalet de Llobregat, Barcelona, Spain; Dept. of Basic Psychology, Campus Bellvitge, University of Barcelona, 08097 L'Hospitalet de Llobregat, Barcelona, Spain; Catalan Institution for Research and Advanced Studies, ICREA, 08010 Barcelona, Spain. Electronic address:

The frontal aslant tract (FAT) is a recently described major connection between the preSMA and Broca's area, whose functional role remains undefined. In this study we examined a patient presenting a morphological overregularization strategy in a verb generation task during awake surgery. This specific language deficit coincided with brain tumor resection at the level of the left FAT.

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Background: Speech segmentation is one of the initial and mandatory phases of language learning. Although some people with aphasia have shown a preserved ability to learn novel words, their speech segmentation abilities have not been explored.

Aims: We examined the ability of individuals with chronic aphasia to segment words from running speech via statistical learning.

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Chemobrain: a systematic review of structural and functional neuroimaging studies.

Neurosci Biobehav Rev

September 2013

Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08097, Spain; Neuro-Oncology Unit, Hospital Universitari de Bellvitge (HUB)-Hospital Duran i Reynals (Institut Català d'Oncologia), L'Hospitalet del Llobregat, Barcelona 08097, Spain.

Nowadays, chemotherapy-induced cognitive impairment or 'chemobrain' is a well-established clinical syndrome, consisting of moderate to subtle cognitive changes across various domains, especially working memory, executive function and episodic verbal memory that persist only in a subgroup of long-term cancer survivors. In recent years, several studies using neuroimaging techniques have reported structural and functional neural changes associated with chemotherapy. This review provides an overview of the relevant advances that neuroimaging techniques have added to the understanding of the underlying mechanisms of chemotherapy-induced cognitive impairment.

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Previous studies have shown that changes in expression of the glycosaminoglycan, hyaluronan (HA) were associated with erosion in areas of post-mortem coronary artery liable to rupture. Angiogenesis is an important feature of ulcerating haemorrhagic plaques prone to rupture. HA is a glycosaminoglycan known to possess potent angiogenic properties on metabolism to oligosaccharides of HA (o-HA) in the presence of hyaluronidase (HYAL) enzymes.

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