4,532 results match your criteria: "Hospital Universitari Germans[Affiliation]"
Cost-effectiveness of sodium zirconium cyclosilicate for the treatment of hyperkalemia in patients with chronic kidney disease or heart failure in Spain.
Nefrologia (Engl Ed)
November 2024
Servicio de Cardiología, Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana (IDIPHISA), Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Background And Objective: Hyperkalemia (HK) is an electrolyte disturbance in the concentration of potassium ions (K), whose risk increases in patients with chronic kidney disease (CKD) or heart failure (HF) and/or in patients being treated with renin-angiotensin-aldosterone system inhibitors (RAASi). The new oral K chelators offer a safe and effective treatment to maintain normokalemia in these patients. The objective of the analysis is to estimate the cost-effectiveness of sodium zirconium cyclosilicate (SZC) for the treatment of chronic HK in patients with CKD or HF versus standard treatment (calcium polystyrene sulfonate and lifestyle modifications) from the perspective of the Spanish National Health System.
View Article and Find Full Text PDFImpact of Dolutegravir plus Lamivudine as First-Line Antiretroviral Treatment on HIV-1 Reservoir and Inflammatory Markers in Peripheral Blood.
J Infect Dis
October 2024
Department of Infectious Diseases, Hospital Universitari Germans Trias i Pujo0l, Badalona, Spain.
Objective: To compare the effects of first-line antiretroviral treatment (ART) with dolutegravir plus lamivudine (DTG+3TC) versus DTG plus emtricitabine/tenofovir alafenamide (FTC/TAF) on the evolution of the HIV-1 reservoir and immune activation biomarkers in people with HIV (PWH).
Methods: DUALITY was a 48-week, single-center, randomized, open-label clinical trial in ART-naïve PWH. Participants were randomized (1:1) to receive ART with DTG+3TC (2DR group) or DTG+FTC/TAF (3DR group).
From detection to intervention, optimizing care for patients with alcohol use disorder and advanced hepatic fibrosis.
Alcohol Clin Exp Res (Hoboken)
December 2024
Division of Gastroenterology and Hepatology, Department of Medicine and Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Genetic and Neurodevelopmental Markers in Schizophrenia-Spectrum Disorders: Analysis of the Combined Role of the Gene and Dermatoglyphics.
Biomedicines
October 2024
FIDMAG Germanes Hospitalàries Research Foundation, 08830 Sant Boi de Llobregat, Spain.
Article Synopsis
- The study investigates the link between dermatoglyphic patterns (fingerprint characteristics) and schizophrenia-spectrum disorders (SSD), suggesting these patterns may reflect neurodevelopmental vulnerabilities.
- Researchers analyzed the relationship between two genetic polymorphisms in the Cannabinoid Receptor 1 gene and three dermatoglyphic markers among 97 patients with SSD and 112 controls.
- Findings indicate that one genetic variant, rs2023239, modifies how dermatoglyphic pattern intensity relates to SSD risk, underscoring the potential role of the endocannabinoid system in neurodevelopment and highlighting the need for further research combining genetics and dermatoglyphics.
Real-world Safety and Efficacy of Risankizumab in Psoriatic Patients: A Multicenter, Retrospective, and Not-interventional Study.
Actas Dermosifiliogr
October 2024
Department of Dermatology, Hospital General Universitario de Valencia, Valencia, España.
Background And Objective: Risankizumab - a humanized monoclonal antibody that targets the p19 subunit of IL-23 - has been recently approved to treat moderate-to-severe plaque psoriasis. Real-world data based on a representative pool of patients are currently lacking.
Objective: To assess the mid- and long-term safety and efficacy profile of risankizumab in patients with moderate-to-severe psoriasis in the routine clinical practice.
Endoscopic subserosal dissection of a giant gastric gastrointestinal stromal tumor with risk factors.
Endoscopy
December 2024
Endoscopy Unit, Teknon Medical Center, Barcelona, Spain.
The 25in25 initiative: A novel transformative project to reduce mortality due to heart failure by 25% in the next 25 years.
Eur J Heart Fail
December 2024
Scottish National Advanced Heart Failure Service, Golden Jubilee National Hospital, Honorary Professor at the University of Glasgow, Glasgow, UK.
Unveiling a Surgical Revolution: The Use of Conventional Histology versus Ex Vivo Fusion Confocal Microscopy in Breast Cancer Surgery.
Cells
October 2024
Department of General and Digestive Surgery, Hospital Universitari Germans Trias I Pujol, Universitat Autònoma de Barcelona (UAB), 08916 Badalona, Spain.
Article Synopsis
- Ex vivo fusion confocal microscopy (EVFCM) is a rapid method for examining breast tissue that could minimize the need for further surgeries by improving the accuracy of cancer detection compared to traditional methods.
- In a study with 36 tissue samples, EVFCM demonstrated high accuracy in detecting neoplastic cases and showed significant agreement with routine histopathology results, especially when evaluated by an experienced Mohs surgeon.
- The findings suggest that using EVFCM could enhance surgical outcomes in breast-conserving surgery by reducing re-excision rates, lowering healthcare costs, and improving both cosmetic and oncological results.
Rare interstitial lung diseases: a narrative review.
J Thorac Dis
September 2024
Division of Respirology and Sleep Medicine, Queen's University, Kingston, ON, Canada.
Article Synopsis
- Interstitial lung diseases (ILDs) include over 200 types, with a growing focus on fibrosing lung diseases due to new therapies, but less common ILDs also need attention because of their poor prognosis.
- This review provides an updated overview of rare ILDs, including idiopathic interstitial pneumonias, genetic disorders like Hermansky-Pudlak syndrome, and conditions associated with lymphoid tissue proliferation, such as follicular bronchiolitis.
- Despite their rarity, improved recognition of imaging and pathology is enhancing our understanding, but these ILDs still pose diagnostic challenges and lack established treatments, highlighting the need for more research.
Validation of 2 clinical scores for transthyretin amyloid cardiomyopathy in a Mediterranean cohort of patients at risk.
Rev Esp Cardiol (Engl Ed)
October 2024
Servicio de Cardiología, Unitat e Insuficiencia Cardiaca, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain; Departamento de Medicina, Universidad Autónoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain. Electronic address:
Unraveling the Molecular Mechanisms of OSA-Related Cardiovascular Event Recurrence: A Post Hoc Analysis From the ISAACC Study.
Arch Bronconeumol
October 2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain; Group of Precision Medicine in Chronic Diseases, Hospital Nacional de Parapléjicos, IDISCAM, Department of Nursing, Physiotherapy and Occupational Therapy, Faculty of Physiotherapy and Nursing, University of Castilla-La Mancha, Toledo, Spain. Electronic address:
Article Synopsis
- Obstructive sleep apnea (OSA) significantly impacts cardiovascular event recurrence in patients with acute coronary syndrome (ACS), particularly in those without prior cardiovascular disease.
- The study identified two groups based on the severity of OSA and utilized proteomics to analyze plasma proteins, revealing 24 differentially expressed proteins associated with OSA severity.
- Bioinformatic analysis suggested that these proteins are involved in key molecular pathways related to immune function, cell signaling, and inflammation, linking OSA to adverse cardiovascular outcomes.
Ten take-home messages on vasopressin use in critically ill patients.
Med Intensiva (Engl Ed)
December 2024
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
The most used vasopressors in critically ill patients are exogenous catecholamines, mainly norepinephrine. Their use can be associated with serious adverse events and even increased mortality, especially if administered at high doses. In recent years, the addition of vasopressin has been proposed to counteract the deleterious effects of high doses of catecholamines (decatecholaminization) with the intention of improving the prognosis of these patients.
View Article and Find Full Text PDFREIV-TOXO Project: Results from a Spanish cohort of congenital toxoplasmosis (2015-2022). The beneficial effects of prenatal treatment on clinical outcomes of infected newborns.
PLoS Negl Trop Dis
October 2024
Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Infantil Vall d'Hebron, Barcelona, Catalonia, Spain.
Background: Some regions of Spain are withdrawing their pregnancy screening program for congenital toxoplasmosis (CT). The Spanish Research Network of Congenital Toxoplasmosis (REIV-TOXO) was created to describe the current status of CT in Spain. The aims of this study were to describe the epidemiological and clinical characteristics of CT and to evaluate the effect of prenatal treatment on clinical outcomes to inform decision-making policies.
View Article and Find Full Text PDFCombined immunohistochemical profile CD10/LMO2/MYC is a useful tool to screen MYC rearrangements in aggressive large B-cell lymphomas.
Virchows Arch
October 2024
Department of Pathology, Hospital del Mar, Hospital del Mar Research Institute-IMIM, Barcelona, Spain.
Article Synopsis
- Aggressive large B-cell lymphomas (LBCL) have diverse biological traits; detecting MYC rearrangements (MYCr) is crucial for understanding their prognosis.
- Current recommendations urge performing cytogenetic tests on all aggressive LBCL cases to identify MYCr, but due to its low occurrence, affordable screening options are necessary.
- Researchers developed a scoring system and algorithm based on immunohistochemical profiles of CD10, LMO2, and MYC to effectively screen for MYCr, achieving high sensitivity and predictive values in both training and validation series.
The journey from silent epidemic to solved mystery: Where we stand and the path forward in meniscal root preservation surgery.
Knee Surg Sports Traumatol Arthrosc
October 2024
Department of Orthopaedic Surgery, Rush University Medical Center, Midwest Orthopaedics at Rush, Chicago, Illinois, USA.
Multidisciplinary approach on the management of glaucoma: the role of corneal biomechanics.
Arch Soc Esp Oftalmol (Engl Ed)
December 2024
Servicio de Oftalmología, Hospital Universitari Germans Trias i Pujol, Badalona (Barcelona), Spain.
Publisher Correction: Patients with Moderate-to-Severe Atopic Dermatitis Maintain Stable Response with No or Minimal Fluctuations with 1 Year of Lebrikizumab Treatment.
Dermatol Ther (Heidelb)
November 2024
Center for Chronic Pruritus and Department of Dermatology, University Hospital Münster, Münster, Germany.
A loop-mediated isothermal amplification test for yaws: a multi-country diagnostic accuracy evaluation.
Lancet Glob Health
November 2024
Faculty of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK; Hospital for Tropical Diseases, London, UK; Division of Infection and Immunity, University College London, London, UK.
Background: To meet the WHO target of eradicating yaws by 2030, highly sensitive and specific diagnostic tools are needed. A multiplex Treponema pallidum-Haemophilus ducreyi loop-mediated isothermal amplification (TPHD-LAMP) test holds promise as a near-patient diagnostic tool for yaws and H ducreyi. We conducted a prospective evaluation in Cameroon, Côte d'Ivoire, Ghana, and the Republic of the Congo to determine the diagnostic accuracy of the TPHD-LAMP test, as well as to assess its acceptability, feasibility, and cost.
View Article and Find Full Text PDFReal-World Evaluation of the Effectiveness and Safety of Dupilumab in Bullous Pemphigoid: An Ambispective Multicenter Case Series.
Br J Dermatol
October 2024
Department of Dermatology. Hospital del Mar Research Institute. Barcelona, Spain. Universitat Pompeu Fabra (UPF). Barcelona, Spain.
Article Synopsis
- - A study evaluated the effectiveness and safety of dupilumab for treating bullous pemphigoid in elderly patients, with a focus on those who typically have other health issues that make standard treatments unsuitable.
- - The results showed that 53.4% of patients achieved complete remission within 4 weeks and 95.7% by week 52, with a significant reduction in itchiness and a dramatic decrease in the need for corticosteroids.
- - The treatment was found to be safe, with most adverse events being mild, and factors like shorter disease duration and exclusive skin involvement were linked to better treatment responses.
Substantia nigra hyperechogenicity and brain ventricular size as biomarkers of early dementia with Lewy bodies.
Alzheimers Res Ther
October 2024
Movement Disorders Unit, Neurology Service. Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.
Article Synopsis
- The study focused on improving the diagnosis of dementia with Lewy bodies (DLB), especially in its early stages, when symptoms can overlap with Alzheimer's and Parkinson's disease.
- Researchers conducted a cross-sectional study comparing newly diagnosed DLB patients to those with Alzheimer's, Parkinson's, and a control group, utilizing transcranial sonography (TCS) to measure specific brain parameters.
- Results indicated that higher echogenicity in the substantia nigra (SN) and wider frontal horns of lateral ventricles were strong predictors for diagnosing DLB, suggesting these TCS parameters could help differentiate DLB from other neurodegenerative disorders.
Understanding and enhancing post-stroke recovery: Insights from a nested qualitative study within the MindFit Project randomized clinical trial.
Complement Ther Med
December 2024
Departament de Psicologia Clínica i Psicobiologia, Facultat de Psicologia, Universitat de Barcelona (UB), Passeig de la Vall d'Hebron, 171, Barcelona 08035, Spain; Institut de Neurociències, Universitat de Barcelona, Passeig de la Vall d'Hebron, 171, Barcelona 08035, Spain; Institut de Recerca Sant Joan de Déu, Santa Rosa 39-57, Esplugues de Llobregat 08950, Spain. Electronic address:
Article Synopsis
- - Participants in the MindFit Project, a study involving chronic stroke survivors, engaged in different intervention groups, including mindfulness-based stress reduction and physical exercise, to address their numerous physical, cognitive, and emotional challenges post-stroke.
- - A qualitative study involving interviews with participants revealed that they found the interventions generally beneficial, with mindfulness helping emotional regulation, physical exercise boosting capabilities, and cognitive training aiding mental functions; the group environment provided peer support despite some challenges related to participant diversity.
- - The findings underscore the complexity of stroke recovery and advocate for holistic, patient-centered rehabilitation strategies that integrate both physical and cognitive approaches, with remote delivery being a practical yet challenging option for survivors.
AML typical mutations (CEBPA, FLT3, NPM1) identify a high-risk chronic myelomonocytic leukemia independent of CPSS molecular.
Blood Adv
January 2025
Grupo Español de Síndromes Mielodisplásicos, Madrid, Spain.
Article Synopsis
- Mutations commonly associated with acute myeloid leukemia (AML) were studied in 127 patients with chronic myelomonocytic leukemia (CMML), revealing varying prevalence rates like CEBPA (7), FLT3 (8), IDH1 (12), IDH2 (26), and NPM1 (11).
- CMML patients with CEBPA, FLT3, and/or NPM1 mutations showed more severe symptoms and higher risk characteristics, indicating they were more frequently linked to the myeloproliferative subtype (MP-CMML).
- The study suggests that these mutations should be included in CMML prognostic models and advocates for treating these patients with AML-type therapies due to their poor
Genome-wide association studies of COVID-19 vaccine seroconversion and breakthrough outcomes in UK Biobank.
Nat Commun
October 2024
Centre for Statistics in Medicine and NIHR Biomedical Research Centre Oxford, NDORMS, University of Oxford, Oxford, UK.
Article Synopsis
- - The study investigated how genetics affects COVID-19 vaccine effectiveness by analyzing UK Biobank data, focusing on vaccine-induced seropositivity and breakthrough infections.
- - Researchers conducted four genome-wide association studies, finding connections between the HLA region and antibody response after vaccination, as well as identifying specific genomic regions linked to breakthrough infections and severity.
- - The results emphasize the importance of individual genetic differences in vaccine responses and help explain reasons for breakthrough infections despite vaccination.
Prediction of left ventricular thrombus after myocardial infarction: a cardiac magnetic resonance-based prospective registry.
Eur J Intern Med
January 2025
Department of Cardiology, Hospital Clínico Universitario de Valencia, Valencia, Spain; INCLIVA Biomedical Research Institute, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBER-CV), Madrid, Spain; Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain. Electronic address:
Background: Left ventricular thrombus (LVTh) is a severe complication after ST-segment elevation myocardial infarction (STEMI).
Objectives: We aim to predict LVTh occurrence by cardiac magnetic resonance (CMR) using clinical, echocardiographic, and electrocardiographic (ECG) variables readily available at admission.
Methods: We included 590 reperfused STEMI patients who underwent early (1-week) and/or late (6-month) CMR in our institution.
Antiviral Treatment and Risk of Hearing Loss in Asymptomatic and Mild Symptomatic Infants With Congenital Cytomegalovirus.
Pediatr Infect Dis J
October 2024
From the Pediatric Infectious Diseases Unit, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain.
Article Synopsis
- The study aimed to evaluate hearing outcomes at 24 months for infants with mild congenital cytomegalovirus (cCMV) infection, comparing those who received antiviral treatment to those who did not.
- Utilizing data from the European Registry of Children with cCMV, researchers included infants diagnosed with cCMV early in life, who had normal physical exams and mild imaging findings.
- Results showed that 34.7% of the 196 participants received antiviral treatment, but there was no significant difference in hearing loss prevalence between treated (4.6%) and untreated groups (6.3%) after two years.