318 results match your criteria: "Hospital Sultanah Bahiyah[Affiliation]"

Fractures of the distal radius are the most common type of forearm fractures seen in children. The most serious outcome of physeal injuries is growth arrest, which can result in deformity and even significant differences in limb length. Therefore, we'd like to share our experience with treating a patient whose left radius stopped growing after she had a physeal injury in an accident.

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  • Paecilomyces spp. are thermo-tolerant fungi that can cause various infections, notably in the paranasal sinuses and occasionally the ear, especially in immunocompromised individuals like diabetics.
  • A case study highlights a 41-year-old male army officer with a severe upper ear infection and intracranial abscess due to Paecilomyces, which was successfully treated through surgery and antifungal medication.
  • The findings underscore the importance of early detection and treatment of such rare fungal infections to prevent serious complications and differentiate them from similar conditions like cholesteatoma.
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Introduction: The MERIT study in Malaysia is a real-world retrospective, observational, multicenter study that evaluated asthma control in patients with uncontrolled asthma who were switched from as-needed (pro re nata [PRN]) budesonide/formoterol or inhaled corticosteroid (ICS) whenever a short-acting beta-agonist (SABA) was taken, to proactive regular dosing of fluticasone propionate/salmeterol (FP/SAL PRD).

Methods: Data from the medical records of patients who were stepped up to FP/SAL PRD were extracted retrospectively at baseline and follow-up (between 3 and 6 months after stepping up to FP/SAL PRD). The primary endpoint was the percentage of patients with improvement in asthma control assessed via the Asthma Control Test (ACT).

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Orbital cellulitis is an infection of the orbital tissue behind the orbital septum. We report a case of a 71-year-old Malay lady, a passive smoker for 20 years, presenting with recurrent orbital cellulitis at the same site. She initially presented with right periorbital swelling, redness, and reduced vision worsening over two weeks, along with a firm swelling over the right temple.

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Successful management of anaphylactic shock prior to elective cesarean delivery: a case report.

JA Clin Rep

October 2024

Department of Obstetric Anesthesiology, Center for Maternal-Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.

Article Synopsis
  • Anaphylactic cardiovascular collapse during pregnancy can be worsened by aortocaval compression and neuraxial anesthesia, with Japanese practices favoring post-anesthesia antibiotic administration, contrary to recommendations.
  • A 24-year-old pregnant woman experienced anaphylactic symptoms after receiving cefazolin before spinal anesthesia for a scheduled repeat cesarean, leading to emergency surgery under general anesthesia.
  • The successful delivery of a healthy neonate and the mother's improved condition post-surgery highlight the necessity of timely antibiotic administration and the effectiveness of swift emergency interventions in severe allergic reactions.
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  • * Researchers reviewed 29 studies that highlight key pharmacist interventions, such as naloxone distribution, education, prescription monitoring, and collaborative care to improve opioid management.
  • * The findings suggest that these pharmacist interventions lead to reduced opioid consumption, enhanced pain management, and improved safety, positioning pharmacists as crucial players in addressing opioid misuse and informing policies.
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  • Tuberculosis (TB) is still widespread in Malaysia, and using cost-effective methods like chest radiography can help in early detection to mitigate its impact, though many cases exhibit normal X-ray results.
  • A study of 56 confirmed smear-positive pulmonary TB cases revealed that about 43% had normal chest radiographs, despite presenting symptoms and positive sputum tests.
  • Factors linked to these normal findings included being under 18, being a student, being single, and being asymptomatic, highlighting the need for thorough testing beyond radiographs to avoid misdiagnosis during outbreaks.
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Microplastics release from coronary catheters: Insights from catheter analysis.

Chemosphere

October 2024

Materials and Manufacturing Research Group, James Watt School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK; Faculty of Engineering, Manipal University Jaipur, Rajasthan, 303007, India; Centre for Research Impact and Outcome, Chitkara University, Punjab, 140401, India. Electronic address:

Microplastics (MP) pose a significant environmental and health risk due to their pervasive presence and potential adverse effects. This study investigates the release of MP from cardiac invasive catheters, which are essential medical devices used in cardiovascular procedures. Twenty-one catheter samples from four diagnostic catheter and three guider catheter brands were analysed using a comprehensive experimental approach.

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Background: Mental health problems among junior doctors in Malaysia pose a significant concern, as they not only adversely affect their overall well-being but also impact the quality of health services they provide. Therefore, it is important to implement interventions aimed at preserving their mental health. This study aimed to evaluate the effectiveness of the Sanubari Optimal Health Program (OHP) intervention in enhancing the mental well-being of junior doctors in Malaysia.

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  • The study investigates how comorbidities impact the quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared to other autoimmune diseases and healthy individuals, utilizing self-reported data from the COVAD-2 survey.
  • Results show IIM patients have significantly higher rates of comorbidities, basic multitasking, complex multitasking, and mental health disorders.
  • The presence of these conditions correlates with lower overall physical and mental health scores, suggesting the need for targeted management strategies for IIM patients based on identified clinical clusters.
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  • Hemoglobin (Hb) Malay is a common genetic disorder in Malaysia caused by a specific mutation, making it difficult to detect using standard laboratory techniques like capillary electrophoresis and high-performance liquid chromatography.
  • This study analyzed samples from 521 patients suspected of having β thalassemia over five years, successfully identifying 54 cases of Hb Malay with notable differences in blood parameters compared to typical β thalassemia carriers.
  • The researchers recommend a new cutoff value for hemoglobin A (HbA) of ≤4.6% to help confirm Hb Malay carrier status, noting that those with Hb Malay may have a different clinical presentation than classical β° thalassemia carriers.
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Tracheal stenosis is a common complication of endotracheal intubation or tracheostomy, resulting in significant morbidity and mortality. Bronchoscope interventions have been proposed as a safe alternative for the management of post-intubation post-intubation tracheal stenosis (PITS). Data for patients diagnosed with PITS across two hospitals, between 2021 and 2022, encompassing demographic, clinical, and procedural details were gathered from electronic medical records, and analysed.

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Background: Quality of life (QOL) is an important clinical endpoint in paediatric chronic conditions. How parent-proxy reports differ from child self-reported QOL in patients with anorectal malformation (ARM) and Hirschsprung's disease (HD) has not been well examined to date. This study evaluates agreement between parent-proxy and child-reported QOL scores in ARM and HD patients compared to healthy controls.

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Introduction: Blood culture contamination remains a dilemma issue in the diagnosis of bloodstream infection. However, to date, there is no national data on blood culture contamination and the common organism isolated in Malaysia. This is a pioneer multi-centre study involving public hospitals with medical microbiologists in Malaysia to determine the blood culture contamination rate and the common organism isolated.

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Eight-and-a-Half Syndrome Secondary to Acute Brainstem Infarction.

Cureus

July 2024

Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS.

Eight-and-a-half syndrome is a rare neuro-ophthalmologic condition, which is characterized by ipsilateral horizontal gaze palsy, internuclear ophthalmoplegia (INO), and ipsilateral lower motor neuron facial palsy. We report a case of eight-and-a-half syndrome secondary to acute brainstem infarction. A 55-year-old gentleman with underlying diabetes mellitus and hypertension presented with a sudden onset of double vision in the right lateral gaze for one day.

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Introduction Spine fracture in association with traumatic dural tear is a serious injury. A traumatic dural tear is difficult to determine based on initial clinical presentation and radiological imaging even with magnetic resonance imaging (MRI). However, during decompression surgery, cerebrospinal fluid leaks surrounding the injured segments are usually confirmed by directly visualizing them.

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  • This study examined the effectiveness and safety of lower doses of osimertinib (20 mg and 40 mg daily) for patients with advanced NSCLC who had previously failed other treatments, compared to the standard 80 mg daily dose.
  • Researchers analyzed data from 22 patients who had the EGFR T790M mutation and found that lower doses resulted in a notable overall response rate of 77.3%, with median progression-free survival of 10 months and overall survival of 13 months.
  • The findings suggest that even patients with poor performance status (ECOG 3 or 4) experienced decent survival outcomes, emphasizing that lower doses of osimertinib could be a viable treatment
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Purpose: Down syndrome (DS) is a common abnormality associated with anorectal malformation (ARM) and Hirschsprung's disease (HD). However, quality of life (QOL) in ARM and HD patients with DS is under-researched. This study compares parent-reported QOL and bowel function in ARM and HD patients with DS to those without.

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LIVERSTAT for risk stratification for patients with metabolic dysfunction-associated fatty liver disease.

J Gastroenterol Hepatol

October 2024

Gastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background And Aim: LIVERSTAT is an artificial intelligence-based noninvasive test devised to screen for and provide risk stratification for metabolic dysfunction-associated fatty liver disease (MAFLD) by using simple blood biomarkers and anthropometric measurements. We aimed to study LIVERSTAT in patients with MAFLD and to explore its role for the diagnosis of advanced fibrosis.

Methods: This is a retrospective study of data from MAFLD patients who underwent a liver biopsy.

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A hierarchical cluster analysis for clinical profiling of tofacitinib treatment response in patients with rheumatoid arthritis.

Clin Rheumatol

August 2024

Centre for Cancer and Stem Cell Research Development and Innovation (IRDI), Institute for Research, IMU University, Kuala Lumpur, Malaysia.

Tofacitinib is the first oral JAK inhibitor approved for treating rheumatoid arthritis (RA). To enhance our understanding of tofacitinib drug response, we used hierarchical clustering to analyse the profiles of patient who responded to the treatment in a real-world setting. Patients who commenced on tofacitinib treatment were selected from 12 major rheumatology centres in Malaysia.

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Background: Children with intravenous immunoglobulin (IVIG) resistant Kawasaki disease (KD) are at higher risk of developing coronary artery (CA) aneurysm. Early identification of high-risk patients using a predictive tool would allow for earlier interventions to prevent cardiac complications.

Methods: Children with KD who were admitted to five selected hospitals in Malaysia between 2008 and 2018 and received 2 g/kg of IVIG within 10 days from the onset of illness were included.

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COVID-19 self-testing is essential for enabling individuals to self-care, screen themselves and, if positive, isolate themselves. Since 2021, COVID-19 self-tests have been extensively used in high-income countries, however, their programmatic implementation in low- and middle-income countries has been delayed. An implementation pilot, mixed-methods study, was conducted in four industrial manufacturing companies, in Kedah State between November 2022 and May 2023.

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Objective: Inappropriate use of short-acting beta2-agonists (SABA) in asthma has been associated with undesired outcomes. This national expert consensus was developed to increase awareness of SABA overuse and provide recommendations on the ways to eliminate SABA overprescription and overreliance in Malaysia.

Data Sources: This expert consensus was developed by searching the PubMed database, using index terms to identify SABA overuse-related burden and recommendations made in asthma guidelines.

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Objectives: Cholecystectomy with or without intraoperative cholangiogram (IOC) is an accepted treatment for cholelithiasis. Up to 11.6 % of cholecystectomies have incidental common bile duct (CBD) stones on IOC and 25.

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