5,798 results match your criteria: "Hospital St[Affiliation]"

Spontaneous omental infarction in an obese young female patient treated with laparoscopy: a case report.

J Surg Case Rep

June 2024

Department of General Surgery, Prof. Dr. Cemil Taşcıoğlu Şehir Hastanesi, 34384 Şişli/Istanbul, Turkey.

Partial infarction of the great omentum is a rare cause of abdominal pain and may present as a surgical emergency. Omental infarction might occur due to its torsion, but cases without obvious cause are reported. Risk factors related to this condition are overweight, obesity, abdominal trauma, recent abdominal surgery, hypercoagulability, postprandial vascular congestion and an increase in intra-abdominal pressure.

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Introduction: Technical advances and the increasing role of interdisciplinary decision-making may warrant formal definitions of expertise in surgical neuro-oncology.

Research Question: The EANS Neuro-oncology Section felt that a survey detailing the European neurosurgical perspective on the concept of expertise in surgical neuro-oncology might be helpful.

Material And Methods: The EANS Neuro-oncology Section panel developed an online survey asking questions regarding criteria for expertise in neuro-oncological surgery and sent it to all individual EANS members.

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Impact of hormonal therapy on HIV-1 immune markers in cis women and gender minorities.

HIV Med

October 2024

Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Background: Although sex hormones are recognized to induce immune variations, the effect of hormonal therapy use on immunity is only poorly understood. Here, we quantified how hormonal therapy use affects HIV-1 immune markers in cis women (CW) and trans women and non-binary people (TNBP) with HIV.

Methods: We considered CD4, CD8 and lymphocyte measurements from cis men (CM), CW and TNBP in the Swiss HIV Cohort Study.

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Background: Advancements in metastatic breast cancer (BC) treatment have enhanced overall survival (OS), leading to increased rates of brain metastases (BM). This study analyzes the association between microsurgical tumor reduction and OS in patients with BCBM, considering tumor molecular subtypes and perioperative treatment approaches.

Methods: Retrospective analysis of surgically treated patients with BCBM from two tertiary brain tumor Swiss centers.

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Intracranial metastasis disease (IMD) has proven to be a frequent secondary occurrence, usually for primary cancers such as lung, breast, and melanoma, which have a high possibility of metastasizing to the brain. Due to the reasons listed above, treatment and early diagnosis are incredibly challenging. In the past decade, medicine has developed much better imaging solutions and radiological and surgical approaches, increasing the postoperative survival prognosis and achieving more time-efficient results.

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Article Synopsis
  • The study aimed to examine if the season during radiotherapy affects the occurrence of grade ≥2 dermatitis in breast cancer patients.
  • It involved a retrospective analysis of 327 patients and considered different seasonal periods and treatment factors but found no significant associations.
  • The conclusion indicates that the season doesn't affect dermatitis rates, suggesting that it's not a key factor for future clinical trials.
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Article Synopsis
  • A multidisciplinary panel from various international medical societies was formed to review literature on imaging techniques for diagnosing pelvic deep endometriosis.
  • They drafted 20 preliminary statements on the topic, which underwent multiple revisions and voting rounds to reach consensus among the panel.
  • Ultimately, the finalized document contains 14 statements with strong agreement, 5 with moderate agreement, and aims to guide clinicians in assessing and treating women suspected of having endometriosis.
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Introduction Despite the constant development of medicine and the increasing accessibility to medical specialists, in the first quarter of the 21 century, odontogenic abscesses remain one of the leading causes of emergency hospitalization in maxillofacial surgery clinics. Because of the serious and lethal complications that this type of suppurative infection can lead to if not treated promptly, there is a need for constant updating of the knowledge of its origin, which is precisely what is addressed in this original article. Materials and methods It reports on a retrospective study conducted over a five-year period (2018-2023), during which 705 patients aged 18 years and older with a confirmed diagnosis of odontogenic soft tissue abscess of the head and neck underwent emergency surgery.

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Article Synopsis
  • The trauma mortality rate is higher in elderly patients due to age-related physiological changes and frailty, necessitating specialized management guidelines to improve outcomes and minimize unnecessary procedures.
  • Expert surgeons reviewed literature and developed evidence-based recommendations for geriatric trauma care, focusing on frailty assessment, early activation of trauma protocols, and multimodal pain management.
  • Key practices include administering antibiotics selectively for certain traumatic injuries, ensuring timely venous thromboembolism prevention, and involving palliative care teams to address end-of-life discussions with a holistic approach.
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Importance: Adequate situational awareness in patient care increases patient safety and quality of care. To improve situational awareness, an innovative, low-fidelity simulation method referred to as Room of Improvement, has proven effective in various clinical settings.

Objective: To investigate the impact after 3 months of Room of Improvement training on the ability to detect patient safety hazards during an intensive care unit shift handover, based on critical incident reporting system (CIRS) cases reported in the same hospital.

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MSL2 variants lead to a neurodevelopmental syndrome with lack of coordination, epilepsy, specific dysmorphisms, and a distinct episignature.

Am J Hum Genet

July 2024

Centre de recherche Azrieli du CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada; Department of Pediatrics, University of Montreal, Montreal, QC H3T 1C5, Canada.

Article Synopsis
  • * A study identified 25 individuals with new variations in the MSL2 gene, who exhibited NDD symptoms such as developmental delays, coordination problems, and autism spectrum disorder, along with other health concerns.
  • * iPSCs from affected individuals showed reduced MSL2 levels and changes in gene expression, leading to the characterization of a new MSL2-related disorder with unique clinical markers and a specific DNA episignature for diagnosis.
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IKAROS-how many feathers have you lost: mild and severe phenotypes in deficiency.

Front Pediatr

May 2024

Department of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Heterozygous germline variants in human encoding for IKAROS define an inborn error of immunity with immunodeficiency, immune dysregulation and risk of malignancy with a broad phenotypic spectrum. Growing evidence of underlying pathophysiological genotype-phenotype correlations helps to improve our understanding of IKAROS-associated diseases. We describe 6 patients from 4 kindreds with two novel variants leading to haploinsufficiency from 3 centers in Germany.

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Traumatic spinal cord injuries (SCIs) continue to be a major healthcare concern, with a rising prevalence worldwide. In response to this growing medical challenge, considerable scientific attention has been devoted to developing neuroprotective and neuroregenerative strategies aimed at improving the prognosis and quality of life for individuals with SCIs. This comprehensive review aims to provide an up-to-date and thorough overview of the latest neuroregenerative and neuroprotective therapies currently under investigation.

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The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) and International Deep Endometriosis Analysis (IDEA) group, the European Endometriosis League (EEL), the European Society for Gynaecological Endoscopy (ESGE), ESHRE, the International Society for Gynecologic Endoscopy (ISGE), the American Association of Gynecologic Laparoscopists (AAGL) and the European Society of Urogenital Radiology (ESUR) elected an international, multidisciplinary panel of gynecological surgeons, sonographers, and radiologists, including a steering committee, which searched the literature for relevant articles in order to review the literature and provide evidence-based and clinically relevant statements on the use of imaging techniques for non-invasive diagnosis and classification of pelvic deep endometriosis. Preliminary statements were drafted based on review of the relevant literature. Following two rounds of revisions and voting orchestrated by chairs of the participating societies, consensus statements were finalized.

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Background: Autonomic dysfunction is common and disabling in Parkinson's disease (PD). The effects of deep brain stimulation (DBS) on the cardiovascular system in PD remain poorly understood. We aimed to assess the effect of DBS on cardiovascular symptoms and objective measures in PD patients.

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Article Synopsis
  • An international panel of specialists from various medical societies was formed to review literature on imaging techniques for diagnosing pelvic deep endometriosis.
  • They drafted 20 consensus statements, with 14 achieving strong agreement and three moderate agreement after voting, refining the remaining statements through discussion.
  • The finalized consensus aims to assist clinicians in the assessment and surgical planning for women suspected of having endometriosis.
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Article Synopsis
  • Endometrial cancer (EC) is a common malignancy in women, and this study analyzed treatment data for over 34,000 patients in Germany from 2000 to 2020 to assess the effectiveness of various therapies.
  • The study found that minimally invasive surgery became more prevalent and was linked to better overall survival compared to traditional open surgery.
  • Additionally, advanced risk patients benefited from multimodal treatments, while specific combinations of surgery, radiation, and chemotherapy showed improved survival rates, especially for high-risk and elderly patients.
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Rapidly destructive coxopathy (RDC) is a rare type of coxarthritis marked by swift deterioration of the hip joint. Although its cause remains unclear, several pathophysiological mechanisms are proposed. To comprehensively analyze this poorly understood condition, a literature search was conducted focusing on associations of bilateral RDC and rheumatoid arthritis (RA).

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Article Synopsis
  • - Detection and diagnosis of colon polyps are crucial for preventing colorectal cancer, and AI technologies can improve colonoscopy effectiveness through computer-aided detection (CADe) and diagnosis (CADx) systems.
  • - The REAL-Colon dataset offers a large collection of 2.7 million native video frames from real-world colonoscopy, featuring 350,000 expert-annotated bounding boxes, which provide a more realistic dataset compared to existing down-sampled images.
  • - This dataset includes comprehensive patient and procedural data, promoting transparency and enabling researchers to develop and benchmark more accurate AI algorithms for improved colonoscopy outcomes.
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Ejection Fraction-Related Differences of Baseline Characteristics and Outcomes in Troponin-Positive Patients without Obstructive Coronary Artery Disease.

J Clin Med

May 2024

Institute of Physiology, Department of Cellular and Translational Physiology and Institute für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr-University Bochum, 44791 Bochum, Germany.

The development and course of myocardial infarction with non-obstructive coronary artery (MINOCA) disease is still not fully understood. In this study, we aimed to examine the baseline characteristics of in-hospital outcomes and long-term outcomes of a cohort of troponin-positive patients without obstructive coronary artery disease based on different left ventricular ejection fractions (LVEFs). We included a cohort of 254 patients (mean age: 64 (50.

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Chronic Pain in Patients with Spinal Muscular Atrophy in Switzerland: A Query to the Spinal Muscular Atrophy Registry.

J Clin Med

May 2024

Division of Neuropediatrics, Development and Rehabilitation, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, 3012 Bern, Switzerland.

Article Synopsis
  • Chronic pain is common in neuromuscular disorders but is under-researched in spinal muscular atrophy (SMA), prompting this study to assess its prevalence and clinical influences.
  • Data from 141 SMA patients revealed that adolescents experienced the highest prevalence of chronic pain at 62%, followed by adults at 48%, and younger children at lower rates.
  • Key factors linked to chronic pain included being female, being an adolescent, and having contractures or scoliosis, highlighting the need for pain management strategies in SMA patients across various age groups.
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The available randomised controlled trials (RCTs) assessing the influence of peritoneal interposition flaps (PIF) on the reduction of symptomatic lymphoceles (sLCs) post robot-assisted radical prostatectomy (RARP) do not constitute a sufficient follow-up (FU) to assess the long-term effects. The PIANOFORTE trial was the first of these RCTs, showing no sLC reduction at the 3-month FU. Therefore, all 232 patients from the PIANOFORTE trial were invited for long-term FU.

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Background: Hip arthroscopy with initial access to the peripheral compartment could reduce the risk of iatrogenic injury to the labrum and cartilage; furthermore, it avoids the need for large capsulotomies with separate portals for peripheral and central (intra-articular) arthroscopy. Clinical results of the peripheral-compartment-first technique remain sparse, in contrast to those of conventional hip arthroscopy starting in the intra-articular central compartment. The purpose of this study was to assess outcome of hip arthroscopy with the peripheral-compartment-first technique, including complication rates, revision rates and patient-reported outcome scores.

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