240 results match your criteria: "Hospital Rangueil[Affiliation]"

Background: Initial clinical studies of pulsed field ablation (PFA) to treat atrial fibrillation (AF) indicated a >90% durability rate of pulmonary vein isolation (PVI). However, these studies were largely conducted in single centers and involved a limited number of operators. The electrophysiological findings and outcomes in patients undergoing repeat ablation after an initial PF ablation for AF are incompletely understood.

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Article Synopsis
  • Pulsed field ablation (PFA) is a new method for treating atrial fibrillation (AF) that focuses on ablating heart tissue while minimizing harm to nearby structures.
  • In the MANIFEST-17K study, data from 106 centers involved 17,642 patients and showed no serious complications like esophageal damage, with only a 1% major complication rate.
  • The results suggest that PFA has a strong safety profile and may change how AF is treated, compared to traditional thermal ablation methods.
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Safety and Effectiveness of Pulsed Field Ablation for Atrial Fibrillation in Patients with Heart Failure: A MANIFEST-PF Sub-analysis.

JACC Clin Electrophysiol

May 2024

Icahn School of Medicine at Mount Sinai, New York, NY, USA;; Cardiology Department, Na Homolce Hospital, Homolka Hospital, Prague, Czechia;. Electronic address:

Background: Atrial fibrillation (AF) and heart failure (HF) coexist, increasing morbidity and mortality. Studies have demonstrated improved outcomes following AF ablation in HF patients with reduced ejection fraction (EF).

Objective: To assess the outcomes of pulsed-field ablation (PFA) in HF.

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Safety and Effectiveness of Pulsed Field Ablation for Atrial Fibrillation in Patients With Heart Failure.

JACC Clin Electrophysiol

May 2024

Icahn School of Medicine at Mount Sinai, New York, New York, USA; Cardiology Department, Na Homolce Hospital, Homolka Hospital, Prague, Czech Republic. Electronic address:

Background: Atrial fibrillation (AF) and heart failure (HF) coexist, increasing morbidity and mortality. Studies have demonstrated improved outcomes following AF ablation in HF patients with reduced ejection fraction (EF).

Objective: This study sought to assess the outcomes of pulsed field ablation (PFA) in HF.

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Article Synopsis
  • The BEAT PAROX-AF trial is a European study comparing pulsed field ablation (PFA) with radiofrequency (RF) ablation for treating drug-resistant paroxysmal atrial fibrillation (AF), focusing on efficacy and safety.
  • A total of 292 participants were randomly assigned to either PFA or RF using specific protocols to measure outcomes such as the recurrence of atrial arrhythmia and serious adverse events.
  • The study began in December 2021 and will conclude recruitment in January 2024, with results expected to be published in mid-2025, aiming to improve treatment strategies for patients with paroxysmal AF.
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  • Electrical storm (ES) is a serious condition characterized by repeated episodes of dangerous heart rhythms (ventricular arrhythmias) occurring within 24 hours, requiring medical intervention.
  • It mainly affects patients with existing heart issues or those with implantable cardioverter-defibrillators (ICDs), and it poses significant health risks despite advanced treatments.
  • The increasing number of older patients with heart conditions and ICDs suggests that the incidence of ES is likely to rise, prompting the need for comprehensive management strategies and a multi-disciplinary approach.
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The real incidence of sudden death: Fair estimations or futile speculations?

Arch Cardiovasc Dis

April 2024

Department of Cardiology, University Hospital Rangueil, 31059 Toulouse, France; I2MC, Inserm UMR 1297, 31432 Toulouse, France. Electronic address:

Article Synopsis
  • The study looks into how many sudden deaths happen in France and finds that estimates vary a lot based on different methods used.
  • In Haute-Garonne, there are about 26 resuscitated sudden deaths and 145 autopsies each year, which helps give a bigger picture for all of France.
  • The researchers think the actual number of sudden deaths might be higher or lower than what was previously thought, and they suggest more careful studies should be done to understand this better.
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Impact of Left Atrial Posterior Wall Ablation During Pulsed-Field Ablation for Persistent Atrial Fibrillation.

JACC Clin Electrophysiol

May 2024

Icahn School of Medicine at Mount Sinai, New York, New York, USA; Cardiology Department, Na Homolce Hospital, Homolka Hospital, Prague, Czech Republic. Electronic address:

Article Synopsis
  • Pulmonary vein isolation (PVI) alone is often inadequate for treating persistent atrial fibrillation, and adding left atrial posterior wall (LAPW) ablation has had mixed results due to concerns about safety and effectiveness.
  • This study compares the safety and effectiveness of PVI combined with LAPW ablation versus PVI alone using pulsed-field ablation (PFA) in patients with persistent atrial fibrillation.
  • Results show no significant difference in freedom from arrhythmias or major adverse events between the two groups, indicating that adding LAPW ablation may not improve outcomes in this patient population.
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Sustainability in healthcare, particularly within the domain of cardiac electrophysiology, assumes paramount importance for the near future. The escalating environmental constraints encountered necessitate a proactive approach. This position paper aims to raise awareness among physicians, spark critical inquiry and identify potential solutions to enhance the sustainability of our practice.

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Ventricular Tachycardia Ablation in Patients With Desmoplakin Cardiomyopathy.

JACC Clin Electrophysiol

March 2024

Section of Electrophysiology, Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

Background: Desmoplakin (DSP) pathogenic variants are rare causes of arrhythmogenic cardiomyopathy and often involve the right and left ventricles. Ventricular tachycardia (VT) ablations may be required in these patients, but procedural characteristics have not been reported.

Objectives: In this study, the authors sought to report a multicenter experience of VT ablation in patients with DSP pathogenic variants.

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Article Synopsis
  • The study aimed to use artificial intelligence (AI) to analyze electrocardiograms (ECGs) from SQTS patients to differentiate between those who had life-threatening arrhythmias and those who did not.
  • Results indicate that AI, particularly shallow neural networks, can enhance the risk assessment process for arrhythmias in SQTS patients, potentially improving clinical outcomes.
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  • Transthyretin amyloidosis (ATTR amyloidosis) is a serious, progressive disease caused by the buildup of transthyretin amyloid fibrils in the body's tissues and organs, and can be hereditary or wild-type.* -
  • The Transthyretin Amyloidosis Outcomes Survey (THAOS) is a major global study launched in 2007 that has tracked over 6,000 patients, including symptomatic patients and asymptomatic carriers, providing important data on the disease's characteristics.* -
  • The recent analysis from THAOS revealed that most symptomatic patients are male, with a shift toward more mixed phenotypes and less predominantly cardiac phenotypes, highlighting the disease's complexity and variability among
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Article Synopsis
  • - The study aimed to compare how effective and safe different treatment schedules with azathioprine (AZA) and rituximab (RTX) are in preventing relapses in patients with ANCA-associated vasculitis who are in complete remission.
  • - Researchers conducted trials that compared 18-month fixed RTX to AZA, 18-month fixed RTX to 18-month tailored RTX, and extended 36-month RTX therapy versus placebo, tracking patient outcomes over 84 months.
  • - Findings indicated that the 18-month fixed RTX regimen was significantly better at preventing major relapses compared to AZA and the tailored RTX approach, leading to a higher remission rate at the 84-month mark.
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Importance: Previous studies evaluating the association of patient sex with clinical outcomes using conventional thermal ablative modalities for atrial fibrillation (AF) such as radiofrequency or cryoablation are controversial due to mixed results. Pulsed field ablation (PFA) is a novel AF ablation energy modality that has demonstrated preferential myocardial tissue ablation with a unique safety profile.

Objective: To compare sex differences in patients undergoing PFA for AF in the Multinational Survey on the Methods, Efficacy, and Safety on the Postapproval Clinical Use of Pulsed Field Ablation (MANIFEST-PF) registry.

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Background: Implantable cardioverter-defibrillators (ICDs) need to reliably detect ventricular tachycardia (VT) and ventricular fibrillation (VF) while avoiding T-wave oversensing (TWOS), which is associated with a risk of inappropriate therapies. The incidence of TWOS with endovascular ICDs appears to differ between manufacturers.

Objectives: We aimed to evaluate the incidence and clinical consequences of TWOS with contemporary Medtronic and Boston Scientific ICDs.

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Background: Efficiency and safety of ablation using half normal saline (HNS) has been shown in refractory ventricular tachycardia (VT), but no evaluation in unselected larger populations has been made.

Objective: To evaluate the efficiency and safety of systematic HNS ablation in VT ablation.

Methods: All successive VT ablations in patients with structural heart disease from 2018 to 2021 used HNS in our center and were retrospectively included.

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Purpose: To compare the oncological and perioperative outcomes of robot-assisted partial nephrectomy (RPN) and percutaneous thermal ablation (PTA) for treatment of T1 renal cell cancer (RCC) in patients older than 75 years.

Materials And Methods: Retrospective national multicenter study included all patients older than 75 years treated for a T1 RCC by RPN or PTA between January 2010 and January 2021. Patients' characteristics, tumor data, and perioperative and oncological outcomes were compared.

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Background: Pacemakers (PMs) and implantable cardioverter-defibrillators (ICDs) increasingly automatically record and remotely transmit nonsustained ventricular tachycardia (NSVT) episodes, which may reveal ventricular oversensing.

Objectives: We aimed to develop and validate a machine learning algorithm that accurately classifies NSVT episodes transmitted by PMs and ICDs in order to lighten health care workload burden and improve patient safety.

Methods: PMs or ICDs (Boston Scientific, St Paul, MN) from 4 French hospitals with ≥1 transmitted NSVT episode were split into 3 subgroups: training set, validation set, and test set.

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Objective: The aim of this study was to compare the long term efficacy of lower limb bypass with that of endovascular treatment (EVT) in patients with chronic limb threatening ischaemia (CLTI).

Methods: This retrospective, multicentre study evaluated the outcomes of patients with CLTI who underwent first time infra-inguinal bypass or EVT. The primary outcome was to compare amputation free survival (AFS) rates between the two propensity score matched groups.

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