Notable correlation between serum epidermal growth factor values and inflammatory status in patients with COVID-19.

Introduction: Despite its crucial role in Epidermal Growth Factor Receptor (EGFR) activation, and the resulting impact on the health-disease process, epidermal growth factor (EGF) is an underexplored molecule in relation to how its serum concentrations relate to other analytes and clinical variables in pathological contexts.

Objective: To clarify the possible correlation between EGF and clinical and analytical variables in the context of COVID-19.

Methods: Cross-sectional observational and analytical study, in patients with virological and clinical diagnosis of COVID-19, selected by simple random sampling, admitted between August and September 2021.

Surgical Antibiotic Prophylaxis: A Proposal for a Global Evidence-Based Bundle.

In the multimodal strategy context, to implement healthcare-associated infection prevention, bundles are one of the most commonly used methods to adapt guidelines in the local context and transfer best practices into routine clinical care. One of the most important measures to prevent surgical site infections is surgical antibiotic prophylaxis (SAP). This narrative review aims to present a bundle for the correct SAP administration and evaluate the evidence supporting it.

A phase 3, randomised, double-blind, placebo-controlled clinical trial evaluation of the efficacy and safety of a SARS-CoV-2 recombinant spike RBD protein vaccine in adults (ABDALA-3 study).

Background: The pandemic of COVID-19 raised the urgent need for safe and efficacious vaccines against SARS-CoV-2. We evaluated the efficacy and safety of a new SARS-CoV-2 virus receptor-binding domain (RBD) vaccine.

Methods: A phase 3, multicentre, randomised, double-blind, placebo-controlled trial was carried out at 18 clinical sites in three provinces of the south-eastern region of Cuba.

Non-Alcoholic Fatty Liver Disease in Cuba.

Introduction: With a global adult prevalence of 24%, non-alcoholic fatty liver disease is a global health problem that parallels the worldwide increase of obesity. Its frequency, clinical characteristics and related diseases in Cuba remain unknown.

Objective: Describe the clinical characteristics, comorbidities and personal habits of patients with non-alcoholic fatty liver disease who are being treated in secondary and tertiary health facilities in seven Cuban provinces.

Dose-response study for the highly aggressive and metastatic primary F3II mammary carcinoma under direct current.

Electrochemical treatment has been suggested as an effective alternative to local cancer therapy. Nevertheless, its effectiveness decreases when highly aggressive primary tumors are treated. The aim of this research was to understand the growth kinetics of the highly aggressive and metastatic primary F3II tumor growing in male and female BALB/c/Cenp mice under electrochemical treatment.

Is cancer a pure growth curve or does it follow a kinetics of dynamical structural transformation?

Background: Unperturbed tumor growth kinetics is one of the more studied cancer topics; however, it is poorly understood. Mathematical modeling is a useful tool to elucidate new mechanisms involved in tumor growth kinetics, which can be relevant to understand cancer genesis and select the most suitable treatment.

Methods: The classical Kolmogorov-Johnson-Mehl-Avrami as well as the modified Kolmogorov-Johnson-Mehl-Avrami models to describe unperturbed fibrosarcoma Sa-37 tumor growth are used and compared with the Gompertz modified and Logistic models.

[Peyronie's disease: treatment with interferon and laser].

Objectives: To evaluate comparatively the results of treatment with interferon, laser and their association in a group of patients with Peyronie's disease.

Methods: We performed an experimental study to evaluate the main results of the treatment of Peyronie's disease with interferon and laser, at Hospital Provincial Universitario "Saturnino Lora Torres" and Hospital General Universitario "Dr. Juan Bruno Zayas Alfonso" in the city of Santiago de Cuba from January 2003 to July 2005.

[External genitalia lymphedema. Case report].

Objectives: Penile and scrotal lymphedema produces a monstrous deformity with psychological impact and occasionally extreme mental anguish. The penis is buried in the scrotal tissue, deformed, thickened, edematous, and curved. The scrotum changes to a great, very thick, hard skin mass, sometimes cracked, exudative, and fetid.

[Buccoepithelial cytologic lesions in workers exposed to chemical products].

Objectives: Our aim was to describe the genetic and cytologic lesions induced by occupational exposition to chemicals (barley powder, carbon dioxide, ammonia, organic solvents, and welding vapors) and to correlate frequencies of appearance of buccoepithelial cytologic disorders with age and toxic habits.

Materials And Methods: This descriptive, transverse observational study was comprised of 77 male workers to obtain information concerning age, on-the-job seniority, time of exposure, direct and indirect exposure, use of breathing protection, and toxic habits. We used exfoliated cells of the buccal mucosa to estimate presence of chromosomal aberrations (micronuclei) and nuclear abnormalities (binucleation, pyknosis, condensed chromatin, and karyolysis).

[Primary intracranial Ewing's sarcoma of the mastoid bone. A case report].

Introduction: Ewing s sarcoma (ES) is a tumorous process that is found mainly in long bones and the pelvis, but its primary location is not often the intracranial zone.

Case Report: We report the case of a 5 year old patient who visited surgery 30 days before hospital admission with increased volume of the left mastoid bone, torticollis, balance disorders and discoordinated movements. A computerised tomography brain scan confirmed our suspicions of a tumorous lesion that was destroying the left mastoid bone, and was invading the projection of the left hemispherium cerebri and edges of the brain stem (mid brain).

[Persistent vegetative state. Paradigm of current discussion on alterations of consciousness].

Introduction: The vegetative state is the current paradigm of discussions about the alterations of conscience.

Development: Although accepted by most investigators, it is still controversial. The dilemma starts with the denomination itself.

[Myasthenia gravis in patients over 50 years of age].

Introduction: A study was made in the Clinical Provincial Hospital for Surgical Teaching Saturnino Lora in Santiago de Cuba. A group of 23 patients over 50 years of age attended this centre and were treated for the onset of myasthenia gravis between January 1983 and December 1997.

Objective And Methods: To determine some of the clinical and evolutive characteristics of the disease such as: sex, age of onset, initial symptoms of the illness, clinical forms and also the different types of treatment used, evolution and mortality.

[Results of preoperative preparation with mannitol in colorectal surgery. January-December 1995].

A study on the results obtained in 20 patients selected by the simple randomized method, who were preoperatively prepared for colorectal surgery with the oral administration of manitol and complementary antimicrobial therapeutics at the ASaturnino Lora@ Provincial Teaching Hospital, in Santiago de Cuba, from January to December, 1995, was conducted aimed at evaluating the results attained with the use of manitol in the preoperative preparation for colorectal surgery, determining its complications, analyzing its advantages, and assessing the patient, nurse and surgeon's opinion about the new procedure. The following variables were taken into account: age, preoperative diagnosis and previous operations. The percentage statistical method was used.

[Spontaneous intracranial hematomas. A surgical solution?].

Introduction: Spontaneous intracranial haematomas pose a fundamental question for the neurosurgeon: Should he operate or not? The main objective of this paper is to consider recent ideas on this subject. A detailed review of the literature was carried out and then discussed.

Development: This study has been structured as supratentorial haematomas, infratentorial haematomas (cerebellum and brainstem) and multiple cerebral haematomas.

[Clinico-pathological study of cerebral death].

Introduction: We present the experience of the Hospital Provincial Clinico Quirúrgico Saturnino Lora, Santiago de Cuba, in the clinical study of brain death.

Material And Methods: We studied 27 cases admitted to hospital between 1994 and 1995. In 74.