3 results match your criteria: "Hospital Preparation of Traditional Chinese Medicine[Affiliation]"
Serum untargeted metabolomics combined with mouse models reveals potential mechanisms of ChengShu QingChu decoction for the treatment of vitiligo.
J Chromatogr B Analyt Technol Biomed Life Sci
February 2025
Uygur Medicine Hospital of Xinjiang Uygur Autonomous Region, No.776 Yanan Road, Urumqi 830049, Xinjiang Uygur Autonomous Region, China; Xinjiang Key Laboratory of Evidence-Based and Translation, Hospital Preparation of Traditional Chinese Medicine, No.776 Yanan Road, Urumqi 830049, Xinjiang Uygur Autonomous Region, China. Electronic address:
To illustrate the potential immunological mechanisms of ChengShu QingChu Decoction (CSQC) in vitiligo treatment. An untargeted metabolomic approach was used to detect serum metabolites in 30 patients with progressive vitiligo. Annotation of the differential metabolites were performed using MetaboAnalyst 5.
View Article and Find Full Text PDF[Qualitative and quantitative analysis of chemical components of Dracocephalum moldavica based on UPLC-Q-TOF-MS/MS and UPLC].
Zhongguo Zhong Yao Za Zhi
December 2024
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS/MS) was used to rapidly identify the chemical components in Dracocephalum moldavica, and UPLC was employed to determine the content of its main components. MS analysis was performed using an electrospray ionization(ESI) source and data were collected in the negative ion mode. By comparing the retention time and mass spectra of reference compounds, and using a self-built compound database and the PubChem database, 68 compounds were identified from D.
View Article and Find Full Text PDFEvaluation of the hepatotoxicity of L. based on a zebrafish model.
Front Pharmacol
February 2024
Uyghur Medical Hospital of Xinjiang Uyghur Autonomous Region, Ürümqi, China.
Article Synopsis
- The study investigates the hepatotoxic effects of an aqueous extract of FP (AEFP) on zebrafish, using different concentrations (40, 50, or 60 μg/mL) to assess mortality rates and liver health indicators.
- Exposure to AEFP (especially at 50 μg/mL) resulted in liver atrophy, increased liver enzyme levels (ALT, AST, γ-GT), and elevated cholesterol levels, indicating significant liver damage.
- Molecular analysis revealed that AEFP inhibits FXR gene expression, disrupts bile acid and lipid metabolism, and alters the expression of several related genes, highlighting its potential as a hepatotoxin.