Cost-effectiveness of omalizumab for the treatment of severe pediatric allergic asthma-Results of a real-life study in Spain.

Background: Severe pediatric allergic asthma (SPAA) induces a huge economic burden in terms of direct, indirect, and intangible costs. The use of omalizumab for the treatment of these patients has produced a significant improvement in several clinical outcomes, but at the same time, the cost for the management of the disease has also increased. The aim of this report was to evaluate whether the use of omalizumab is cost-effective.

Infective endocarditis in paediatric patients from Andalusia (Spain), 2008-2020.

Introduction: Paediatric infective endocarditis (IE) is a serious condition associated with significant mortality. Information in Spain is limited and comes from case series from single centres. The aim was to describe the epidemiology, clinical features, microbiology and outcome of paediatric IE in Andalusia.

[Prevalence of pain and musculoskeletal diseases in adult population in Osuna Health Management Area].

Objective: The main aim of this study is to determine the prevalence of PRMD (playing-related musculoskeletal disorders) in adults exposed to it due to their profession, in the area of Osuna.

Design: It is a cross-sectional study. Site: the study is based on data collected in the local community of musicians (music schools, conservatories and music bands from the region).

Predictive Model for the Diagnosis of Uterine Prolapse Based on Transperineal Ultrasound.

We want to describe a model that allows the use of transperineal ultrasound to define the probability of experiencing uterine prolapse (UP). This was a prospective observational study involving 107 patients with UP or cervical elongation (CE) without UP. The ultrasound study was performed using transperineal ultrasound and evaluated the differences in the pubis−uterine fundus distance at rest and with the Valsalva maneuver.

Variability in Phelan-McDermid Syndrome in a Cohort of 210 Individuals.

Phelan-McDermid syndrome (PMS, OMIM# 606232) results from either different rearrangements at the distal region of the long arm of chromosome 22 (22q13.3) or pathogenic sequence variants in the gene. codes for a structural protein that plays a central role in the formation of the postsynaptic terminals and the maintenance of synaptic structures.

Interobserver variability of ultrasound measurements for the differential diagnosis of uterine prolapse and cervical elongation without uterine prolapse.

Objectives: Our study aims to determine the interobserver variability of different ultrasound measurements (pubis-cervix distance, pubis-uterine fundus distance, and pubis-Douglascul-de-sac distance) previously analyzed for the ultrasound differential diagnosis of uterine prolapse (UP) and cervical elongation CE without UP.

Materials And Methods: We conducted a prospective observational study with 40 patients scheduled to undergo surgical correction of UP and CE without UP. All patients underwent pelvic floor ultrasound examination by an examiner (E1) who acquired ultrasound images.

Epidemiology and prognosis of patients with a history of cancer admitted to intensive care. A multicenter observational study.

Objective: To assess the epidemiology and outcome at discharge of cancer patients requiring admission to the Intensive Care Unit (ICU).

Design: A descriptive observational study was made of data from the ENVIN-HELICS registry, combined with specifically compiled variables. Comparisons were made between patients with and without neoplastic disease, and groups of cancer patients with a poorer outcome were identified.

Omalizumab outcomes for up to 6 years in pediatric patients with severe persistent allergic asthma.

Background: Various studies have assessed omalizumab outcomes in the clinical practice setting but follow-up and/or number of patients included were limited. We aim to describe the long-term outcomes of pediatric patients with severe persistent allergic asthma receiving omalizumab in the largest real-life cohort reported to date.

Methods: ANCHORS was a multicenter, observational, retrospective cohort study conducted in 25 Pediatric Allergy and Pulmonology units in Spain.

Differential diagnosis of middle compartment pelvic organ prolapse with transperineal ultrasound.

Introduction And Hypothesis: The objective was to identify the best parameter (pubis-cervix measurement, pubis-uterine fundus measurement or pubis-pouch of Douglas measurement) on transperineal ultrasound, based on the difference between measurements taken at rest and with the Valsalva maneuver, for presurgical differential diagnosis between uterine prolapse (UP) and cervical elongation (CE) without UP.

Methods: A prospective observational study of 60 consecutively recruited patients who underwent corrective surgery of the middle compartment (UP or CE without UP). A transperineal ultrasound was performed, and the descent of the pelvic organ was measured in relation to the posteroinferior margin of the pubis in the midsagittal plane, referencing the uterine fundus, pouch of Douglas and the cervix at rest and with the Valsalva test.

Prevalence of advanced heart failure and use of palliative care in admitted patients: Findings from the EPICTER study.

Introduction And Aim: Palliative care in patients with advanced heart failure is strongly recommended by Clinical Practice Guidelines. We aimed to calculate the prevalence of advanced heart failure in admitted patients, to describe their management, and to analyse the factors that influence their referral to specialised palliative care.

Patients And Methods: Cross-sectional, multicentre study that consecutively included patients admitted for heart failure in 74 Spanish hospitals.

Hybrid treatment of penetrating aortic ulcer.

Penetrating atherosclerotic aortic ulcer is a rare entity with poor prognosis in the setting of acute aortic syndrome. In the literature, cases like the present one, located in the aortic arch, starting with chest pain and evolving with dysphonia, are even rarer. The present report emphasizes the role played by computed tomography in the diagnosis of penetrating atherosclerotic ulcer as well as in the differentiation of this condition from other acute aortic syndromes.

Welfare Homes for Patients Living with HIV/AIDS in Andalusia.

Aims: To study the AIDS welfare homes (AWHs) in Andalusia, assess their resources and the services provided, and describe the characteristics of their residents.

Patients And Methods: Cross-sectional, observational study; an interview questionnaire technique was used with the managers and the residents of the AWHs.

Results: A total of 7 AWHs and 96 residents were included; 32% of the staff were health care workers and 45.

Pelvic venous congestion syndrome: case report.

Objective: To remind the existence of pelvic venous congestion syndrome as a diagnostic possibility in women with chronic or relapsing abdominal pain that simulates repetitive renal colic, in which common diagnostic tests do not show any positive finding.

Methods: We present the case of a 36-year-old woman with a picture of unilateral relapsing abdominal pain that, after many visits to the emergency room is sent for study with the diagnosis of renal colic. Ultrasound, intravenous urogram and ureteroscopy did not demonstrate any pathological finding.

Analytical performance evaluation of a particle-enhanced turbidimetric cystatin C assay on the Roche COBAS 6000 analyzer.

Objectives: Cystatin C is a low molecular protein that has been proposed to estimate the glomerular filtration rate. Here we investigated the performance of the Roche cystatin C assay on the COBAS 6000 analyzer.

Design And Methods: We studied the imprecision, recovery, limit of detection and quantification, linearity and interferences.