28 results match your criteria: "Hospital Neuwerk[Affiliation]"

Background: Chronic postsurgical pain is a considerable source of disabling neuropathic pain. Rates of knee replacement surgeries are increasing, and many patients report chronic postsurgical pain in their wake. When conventional therapies prove ineffective, neuromodulation options such as dorsal root ganglion stimulation (DRGS) may be used.

View Article and Find Full Text PDF

Oral cancer prediction by noninvasive genetic screening.

Int J Cancer

January 2023

Department of Otolaryngology/Head and Neck Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.

Article Synopsis
  • Oral squamous cell carcinomas (OSCCs) can develop in invisible, genetically altered areas of the mouth, often only identifiable by white lesions known as oral leukoplakia (OL).
  • A new noninvasive genetic test using next-generation sequencing (NGS) on brushed cells has shown high accuracy in detecting these alterations, even in patients without visible symptoms.
  • The study also highlights common genetic mutations in OL, suggesting that noninvasive genetic screening could effectively identify high-risk individuals for oral cancer and monitor disease progression.
View Article and Find Full Text PDF
Article Synopsis
  • Fanconi anemia (FA) is a rare genetic disorder characterized by malformations at birth, early bone marrow failure, and a heightened risk of cancers like leukemia and squamous cell carcinoma.
  • The disease is linked to mutations in 23 genes affecting DNA repair, but even within the same family, patients with the same mutations can have varied symptoms, indicating the role of epigenetics.
  • Vitamin D, particularly its active form, influences cell growth and immune function, suggesting that individual vitamin D levels may impact FA's clinical symptoms by modulating epigenetic changes in immune cells.
View Article and Find Full Text PDF
Article Synopsis
  • Individuals with Fanconi anemia (FA) face a significantly higher risk of oral squamous cell carcinoma (SCC) and limited treatment options, making early detection crucial.
  • The study evaluated the effectiveness of oral brush biopsy-based cytology over 12 years in a large cohort of 713 FA patients, analyzing 1233 visible oral lesions and using DNA ploidy for inconclusive results.
  • Results showed high diagnostic accuracy with a sensitivity of 97.7% and specificity of 84.5% for cytology, which improved to 100% sensitivity when DNA analysis was included, helping to identify early stage oral lesions and reduce the need for invasive procedures.
View Article and Find Full Text PDF
Article Synopsis
  • - Fanconi anemia is a rare genetic disorder that increases the risk of developing squamous cell carcinoma in the head, neck, and anogenital regions, with an 800-fold higher risk compared to the general population.
  • - The study investigates whether human polyomaviruses contribute to head and neck cancers in patients with Fanconi anemia using a technique that detects specific viral proteins.
  • - Results showed weak detection of these viruses in only 17% of cancer samples, suggesting that human polyomaviruses are likely not a direct cause of the squamous cell carcinomas examined.
View Article and Find Full Text PDF

Augmented Reality, Cyber-Physical Systems and Robotic Surgery: Nice to Have or a Program with Future?

Visc Med

February 2018

Surgical Working Group of Young Surgeons (CAJC; chair and co-chair) of the DGAV (German Society for General and Visceral Surgery), Berlin, Germany.

View Article and Find Full Text PDF

Background: Prophylactic mesh-augmented reinforcement during closure of abdominal wall incisions has been proposed in patients with increased risk for development of incisional hernias (IHs). As part of the BioMesh consensus project, a systematic literature review has been performed to detect those studies where MAR was performed with a non-permanent absorbable mesh (biological or biosynthetic).

Methods: A computerized search was performed within 12 databases (Embase, Medline, Web-of-Science, Scopus, Cochrane, CINAHL, Pubmed publisher, Lilacs, Scielo, ScienceDirect, ProQuest, Google Scholar) with appropriate search terms.

View Article and Find Full Text PDF

Laparoscopic surgery has generated a revolution in operative medicine during the past few decades. Although strongly criticized during its early years, minimization of surgical trauma and the benefits of minimization to the patient have been brought to our attention through the efforts and vision of a few pioneers in the recent history of medicine. The German gynecologist Kurt Semm (1927-2003) transformed the use of laparoscopy for diagnostic purposes into a modern therapeutic surgical concept, having performed the first laparoscopic appendectomy, inspiring Erich Mühe and many other surgeons around the world to perform a wide spectrum of procedures by minimally invasive means.

View Article and Find Full Text PDF

Endovascular vs Open Aneurysm Repair in the Young: Systematic Review and Meta-analysis.

J Endovasc Ther

December 2015

Vascular Surgery Unit, Department of Cardiothoracic and Vascular Surgery, University Hospital of Heraklion, University of Crete Medical School, Heraklion, Greece

Purpose: To examine the results of elective abdominal aortic aneurysm (AAA) repair in young patients (<70 years old) and compare the outcome of endovascular aneurysm repair (EVAR) and open surgical repair (OSR) techniques.

Methods: The MEDLINE, CENTRAL, and OpenGray databases were searched from January 2000 to March 2015. Periprocedural (30-day mortality and morbidity, length of hospitalization) and long-term outcomes (long-term mortality, rate of secondary procedures) were compared between young patients undergoing EVAR and OSR.

View Article and Find Full Text PDF

Background: Evidence for open groin hernia repair demonstrates less pain with bioglue mesh fixation compared with invasive methods. This study aimed to assess the short- and long-term effects of laparoscopic groin hernia repair with noninvasive and invasive mesh fixation.

Data Sources: A systematic review of MEDLINE, CENTRAL, and OpenGrey was undertaken.

View Article and Find Full Text PDF

Background: Measures have been taken to improve methodological quality of randomized controlled trials (RCTs). This review systematically assessed the trends in volume and methodological quality of RCTs on minimally invasive surgery within a 10-year period.

Data Sources: RCTs on minimally invasive surgery were searched in the 10 most cited general surgical journals and the 5 most cited journals of laparoscopic interest for the years 2002 and 2012.

View Article and Find Full Text PDF

Background: Single-incision laparoscopic surgery poses significant ergonomic limitations. Curved instruments have been developed in order to address the issue of lack of triangulation. Direct comparison between single-incision laparoscopic surgeries with conventional linear and curved instruments has not been performed to date.

View Article and Find Full Text PDF

Purpose: Laparoscopic repair of large hiatal hernias is associated with high recurrence rates. Erosion and mesh migration are rare but devastating complications of synthetic mesh repair, whereas reoperation is accompanied by significant operative morbidity. The aim of this study was to estimate the comparative risk of hernia recurrence following primary suture or biologic mesh repair.

View Article and Find Full Text PDF

The clinical effects of laparoscopy in the pulmonary function of obese patients have been poorly investigated in the past. A systematic review was undertaken, with the objective to identify published evidence on pulmonary complications in laparoscopic surgery in the obese. Outcome measures included pulmonary morbidity, pulmonary infection and mortality.

View Article and Find Full Text PDF

Meta-analysis of laparoscopic vs open cholecystectomy in elderly patients.

World J Gastroenterol

December 2014

Stavros A Antoniou, Frank A Granderath, Center for Minimally Invasive Surgery, Hospital Neuwerk, 41066 Mönchengladbach, Germany.

Aim: To investigate the comparative effect of laparoscopic and open cholecystectomy in elderly patients.

Methods: Laparoscopic cholecystectomy has induced a revolution in the treatment of gallbladder disease. Nevertheless, surgeons have been reluctant to implement the concepts of minimally invasive surgery in older patients.

View Article and Find Full Text PDF

Background And Aims: Self-expanding metallic stents are increasingly used in the management of malignant and benign colorectal obstructions. We aimed to identify relevant predictive factors for stent failure and stent-related complications.

Material And Methods: We conducted a retrospective single-center analysis of 204 consecutive patients who underwent emergency colorectal stenting procedures because of symptomatic bowel obstructions from 1996 to 2011 at the Sisters of Charity Hospital Linz, Austria.

View Article and Find Full Text PDF

Background: Increasing life expectancy requires specific attention on geriatric patients. Data support a potential reduction of surgical morbidity for patients undergoing laparoscopic surgery as compared to conventional surgery. The aim of this study was to investigate the comparative effect of laparoscopic and open colorectal surgery on geriatric patients.

View Article and Find Full Text PDF

Is laparoscopic ileocecal resection a safe option for Crohn's disease? Best evidence topic.

Int J Surg

September 2014

Center for Minimally Invasive Surgery, Hospital Neuwerk, Dünner Str. 214-216, 41066 Mönchengladbach, Germany.

A best evidence topic was constructed according to a structured protocol. The question addressed was whether laparoscopic ileocecal resection for Crohn's disease is associated with higher morbidity rates in comparison to open surgery. From a total of 123 articles, 11 studies provided the best available evidence on this topic.

View Article and Find Full Text PDF

Background: The aim of the present study was to comparatively evaluate the outcomes of laparoscopic transabdominal preperitoneal inguinal hernia repair and totally extraperitoneal repair.

Methods: The electronic databases of Medline, EMBASE, and the Cochrane Central Register of Controlled Trials were searched, and a meta-analysis of randomized clinical trials was undertaken.

Results: Seven studies comprising 516 patients with 538 inguinal hernia defects were identified.

View Article and Find Full Text PDF

Background And Objectives: Laparoscopic treatment of perforated peptic ulcer (PPU) has been introduced as an alternative procedure to open surgery. It has been postulated that the minimally invasive approach involves less operative stress and results in decreased morbidity and mortality.

Methods: We conducted a meta-analysis of randomized trials to test this hypothesis.

View Article and Find Full Text PDF

Background: Trocar-associated visceral injuries are rare but potentially fatal complications of laparoscopic access. More commonly, abdominal wall bleeding occurs, which usually requires hemostatic measures and prolongs operative time. Blunt-tipped trocars have been postulated to carry a lower risk of abdominal wall bleeding and intra-abdominal injuries.

View Article and Find Full Text PDF

Lower recurrence rates after mesh-reinforced versus simple hiatal hernia repair: a meta-analysis of randomized trials.

Surg Laparosc Endosc Percutan Tech

December 2012

Department of General and Visceral Surgery, Center for Minimally Invasive Surgery, Hospital Neuwerk, Mönchengladbach, Germany.

Mesh hiatoplasty has been postulated to reduce recurrence rates, it is however prone to esophageal stricture, and early-term and mid-term dysphagia. The present meta-analysis was designed to compare the outcome between mesh-reinforced and primary hiatal hernia repair. The databases of Medline, EMBASE, and the Cochrane Library were searched; only randomized controlled trials entered the meta-analytical model.

View Article and Find Full Text PDF

Mesh-reinforced hiatal hernia repair: a review on the effect on postoperative dysphagia and recurrence.

Langenbecks Arch Surg

January 2012

Department of General and Visceral Surgery, Certified Reference Center for Minimally Invasive Surgery, Hospital Neuwerk, Mönchengladbach, Germany.

Purpose: The objective of the present study was to review the pertinent literature and analyze the evidence for and against the use of mesh for hiatal hernia repair, with a focus on the effects on recurrence and postoperative dysphagia.

Methods: A literature search was performed between January 1990 and March 2010. Studies were considered for inclusion, provided (1) they comprised a series of at least 20 patients, (2) they documented a follow-up period of at least 6 months, (3) they reported on the outcome as expressed by hernia recurrence rates, and (4) they reported on type of mesh material, hiatal closure, and antireflux surgery.

View Article and Find Full Text PDF