12 results match your criteria: "Hospital Marina-Salud de Denia[Affiliation]"

Analysis of the expression of the Serpina1 gene in SARS-CoV-2 infection: study of a new biomarker.

Rev Clin Esp (Barc)

May 2024

Facultad de Medicina, Universidad de Zaragoza, Spain; Insitututo de Investigación Sanitaria de Aaragón, España; Unidad de Enfermedades Minoritarias, Servicio de Medicina Interna, Hospital Universitario "Lozano Blesa", Zaragoza, Spain; Grupo de Trabajo de Enfermedades Minoritarias de la Sociedad Española de Medicina Interna, España. Electronic address:

Introduction: The SERPINA1 gene encodes the protein Alpha-1 Antitrypsin (AAT1). Possible imbalances between the concentrations of proteases and antiproteases (AAT1) can lead to the development of serious pulmonary and extrapulmonary pathologies. In this work we study the importance of this possible imbalance in patients with COVID-19.

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Currently, there is a growing interest in the study of fertility because fertility-related problems affect up to 15% of the world's population. The aim of this study was to determine the influence of the Mediterranean diet on seminal quality in men of reproductive age. For this purpose, a systematic review of the literature was carried out following the PRISMA method.

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Article Synopsis
  • * Sotagliflozin demonstrated effectiveness in reducing hospitalizations for heart failure during the SOLOIST-WHF trial, where it was administered during hospitalization or shortly after discharge.
  • * Empagliflozin has also proven to be safe and beneficial in heart failure patients, as shown in the EMPA-RESPONSE-AHF and EMPULSE trials, with ongoing research on dapagliflozin in the DAPA ACT HF-TIMI 68 trial highlighting the potential of SGLT2 inhibitors in acute heart failure
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  • Cutaneous leiomyomas consist of three types: piloleiomyomas (PL), angioleiomyomas (AL), and genital leiomyomas (GL), with each having distinct clinical and histological traits.
  • A review of 255 cases from two hospitals showed that PL had an incidence of 4.3 cases per million annually, with PL patients having a higher frequency of breast cancer compared to other types.
  • The findings suggest a need to revise the classification of nipple leiomyomas and further investigate the link between PL and breast cancer risk.
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Aims: To validate a translated and culturally adapted version of the Morisky Medication Adherence Scale for use in Spanish population, and to examine the psychometric properties of this scale in patients with type 2 diabetes mellitus in Spain.

Design: This cross-sectional study was conducted in a single university hospital in Spain. Patients diagnosed with type 2 diabetes mellitus at least 1 year before inclusion, being treated with anti-diabetic medication were included.

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The role of Kirsten rat sarcoma viral oncogene homolog (KRAS) and neuroblastoma RAS viral oncogene homolog (NRAS) mutations as negative predictors for anti-epidermal growth factor receptor (EGFR) therapies in metastatic colorectal cancer (CRC) has been firmly established. However, whether the RAS mutation status plays a role as a biomarker for anti-vascular endothelial growth factor (VEGF) treatment remains controversial. Data from 93 CRC patients who received first-line cytotoxic chemotherapy with fluoropyrimidines and oxaliplatin, with or without bevacizumab, were analyzed.

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Background: Malignant thyroid teratomas are rare tumors with a poor prognosis. Little is known about their pathogenesis or treatment. Here, the case is reported of an adult woman with an aggressive thyroid teratoma with primitive neuroectodermal tumor (PNET) malignant transformation, successfully managed with neoadjuvant chemotherapy and surgery.

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