Peripheral neuropathy in patients with hepatitis virus C infection in the Amazon region.

Introduction: Hepatitis virus C (HCV) infection is considered a health problem in the State of Acre localized in the Brazilian Amazon which has a prevalence rate of 5.9%. Peripheral neuropathy is a common extra-hepatic manifestation in patients with HCV.

Topiramate and severe metabolic acidosis: case report.

Topiramate infrequently induces anion gap metabolic acidosis through carbonic anhydrase inhibition on the distal tubule of the nephron--a type 2 renal tubular acidosis. We report on a 40 years old woman previously healthy that developed significant asymptomatic metabolic acidosis during topiramate therapy at a dosage of 100 mg/day for three months. Stopping medication was followed by normalization of the acid-base status within five weeks.

An evaluation of gender, obesity, age and diabetes mellitus as risk factors for carpal tunnel syndrome.

Objectives: The aim of this study is to identify gender, high body mass index (BMI), age and diabetes mellitus (DM) as independent risk factors (RF) for carpal tunnel syndrome (CTS) and to analyse the strength of association of these factors, both globally and in individual subgroups.

Methods: We performed a case-control study with 791 CTS cases and 981 controls. Patients were selected from those referred to nerve conduction studies and electromyography in 3 university hospitals and two private services.