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Hospital Luis Calvo Mackenna[Affiliation] Publications | LitMetric

266 results match your criteria: "Hospital Luis Calvo Mackenna[Affiliation]"

Performance of the VITEK® MS system for the identification of filamentous fungi in a microbiological laboratory in Chile.

PLoS One

December 2024

Laboratorio Clínico, Clínica Alemana, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.

Filamentous fungi are an emergent cause of severe infections in immunocompromised patients. Timely and accurate identification is crucial to initiate appropriate therapy. Traditional identification methods are time-consuming, labor-intensive, and operator-dependent.

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Article Synopsis
  • Thromboembolic events are uncommon in children, but awareness and treatment plans are crucial for timely care.
  • A case study describes a 12-year-old girl with severe respiratory issues and signs of pulmonary thromboembolism, confirmed by imaging.
  • After starting anticoagulant therapy and addressing her instability with multiple medications, systemic thrombolysis using alteplase successfully improved her condition without significant complications.
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Article Synopsis
  • RSV is the top cause of severe respiratory infections in children and has seen a rise in cases post-pandemic, especially in low- and middle-income countries.
  • Traditional treatments have been mainly supportive, but new preventive measures like long-acting monoclonal antibodies and vaccinations for pregnant women are becoming available.
  • The Latin American Pediatric Infectious Diseases Society (SLIPE) is assessing the impact of RSV in the LAC region and recommending new strategies for prevention.
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Respiratory viral infections in children with cancer and febrile neutropenia and children undergoing hematopoietic stem cell transplantation.

Curr Opin Infect Dis

October 2024

Division of Pediatric Infectious Diseases, Department of Pediatrics, Hospital Luis Calvo Mackenna, Faculty of Medicine, Universidad de Chile, Santiago, Chile.

Purpose Of Review: The scope of this review is to understand the epidemiology and potential role of respiratory viral infections in children with cancer and febrile neutropenia, as well as in children, undergoing hematopoietic stem cell transplantation. Early detection of respiratory viral infections through molecular diagnostic techniques has allowed recent randomized clinical studies to advance the possibility of more rational use of antimicrobials in this susceptible population.

Recent Findings: Progress has been made in the early detection of respiratory viruses in episodes of fever and neutropenia in children with cancer.

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Article Synopsis
  • Congenital thyroid dyshormonogenesis (CHD) in newborns results from disrupted thyroid hormone synthesis, often due to hereditary mutations, particularly in the thyroid peroxidase (TPO) enzyme gene.
  • A study involving 12 Chilean patients with CHD found two possibly pathogenic mutations in the TPO gene, affecting 16.6% of the participants.
  • Findings from this work could facilitate genetic counseling for families impacted by this condition, given the genetic basis of some cases.
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Corrigendum: Case report: Unveiling a less severe congenital nephrotic syndrome in a Rapa Nui patient with a  Maori founder variant.

Front Nephrol

July 2024

Departamento de Pediatría y Cirugía Infantil Oriente, Facultad de Medicina, Universidad de Chile, Santiago de Chile, Chile.

[This corrects the article DOI: 10.3389/fneph.2024.

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Multilocus inherited neoplasia allele syndrome: report of uncommon combinations between and genes.

Ecancermedicalscience

May 2024

Unidad Asesoramiento Genético Oncológico, Fundación Arturo López Pérez, Santiago 7500691, Chile.

Background: Multilocus inherited neoplasia allelic syndrome (MINAS) is a recently coined term that describes the coexistence of two or more pathogenic variants (PVs) in cancer susceptibility genes (CSGs) in a single individual.

Case Presentation: This article presents two cases of MINAS due to rare CSG combinations. The first was a 37-year-old woman carrying PVs in the mutated ataxia telangiectasia () and genes, with HER-2 positive unilateral breast cancer at 29.

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Background: Latin America has a high prevalence of Helicobacter pylori in children that may lead to peptic ulcer disease and eventually gastric cancer in adulthood. Successful eradication is hindered by rising antimicrobial resistance. We summarize H.

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This article will provide an overview of how speech and resonance can be impacted in children with cleft palate. The authors will outline evidence-based assessment and treatment approaches commonly used for children with cleft palate and provide information on current initiatives to provide speech therapy. The methods discussed will be the use of telehealth to provide access to speech therapy for patients in areas without speech-language pathologists and the use of speech therapy camps to offer intensive, limited-duration speech therapy for groups of children due to the lack of trained providers in certain geographical regions.

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Case report: Unveiling a less severe congenital nephrotic syndrome in a Rapa Nui patient with a Maori founder variant.

Front Nephrol

May 2024

Departamento de Pediatría y Cirugía Infantil Oriente, Facultad de Medicina, Universidad de Chile, Santiago de Chile, Chile.

Background: Congenital nephrotic syndrome (CNS) is a severe kidney disorder characterized by edema, massive proteinuria, and hypoalbuminemia that manifests or within three months after birth. CNS affects 1-3 per 100,000 children, primarily associated with genetic variants and occasionally with infections. Genetic analysis is the first-line method for diagnosis.

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Unlabelled: Growth hormone (GH) is effective in improving height in several conditions.

Objective: To describe the evolution of a group of children who received GH in a tertiary center between 2012-2022.

Patients And Method: Descriptive, retrospective study.

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Background: Several screening strategies for identifying congenital CMV (cCMV) have been proposed; however, the optimal solution has yet to be determined. We aimed to determine the prevalence of cCMV by universal screening with saliva pool testing and to identify the clinical variables associated with a higher risk of cCMV to optimize an expanded screening strategy.

Methods: We carried out a prospective universal cCMV screening (September/2022 to August/2023) of 2186 newborns, analyzing saliva samples in pools of five (Alethia-LAMP-CMV) and then performed confirmatory urine CMV RT-PCR.

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The COVID-19 pandemic presented numerous challenges that required immediate attention to mitigate its devastating consequences on a local and global scale. In March 2020, the Chilean government, along with health and science authorities, implemented a strategy aimed at generating relevant evidence to inform effective public health decisions. One of the key strengths of this strategy was the active involvement of the scientific community, employing transdisciplinary approaches to address critical questions and support political decision-making.

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Pediatric anesthesiology in Brazil, Chile, and Mexico.

Paediatr Anaesth

September 2024

Children's Hospital of Philadelphia, USA Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Background: Latin America comprises an extensive and diverse territory composed of 33 countries in the Caribbean, Central, and South America where Romance languages-languages derived from Latin are predominantly spoken. Economic disparities exist, with inequitable access to pediatric surgical care. The Latin American Surgical Outcomes Study in Pediatrics (LASOS-Peds), a multi-national collaboration, will determine safety of pediatric anesthesia and perioperative care.

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Background: The COVID-19 pandemic has brought significant mental health challenges, particularly for vulnerable populations, including non-binary gender individuals. The COMET international study aimed to investigate specific risk factors for clinical depression or distress during the pandemic, also in these special populations.

Methods: Chi-square tests were used for initial screening to select only those variables which would show an initial significance.

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Outcomes of retrograde ureteroscopy in Chinese infants and toddlers under 3 years old with ureteric stones from a single center.

J Pediatr Urol

June 2024

Hospital Luis Calvo Mackenna, Santiago, Chile; Hospital San Juan De Dios, Santiago, Chile; Clinica MEDS, Santiago, Chile. Electronic address:

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Background: The prevalence of medical illnesses is high among patients with psychiatric disorders. The current study aimed to investigate multi-comorbidity in patients with psychiatric disorders in comparison to the general population. Secondary aims were to investigate factors associated with metabolic syndrome and treatment appropriateness of mental disorders.

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Genetic Polymorphisms and Tumoral Mutational Profiles over Survival in Advanced Colorectal Cancer Patients: An Exploratory Study.

Curr Oncol

January 2024

Laboratory of Chemical Carcinogenesis and Pharmacogenetics, Department of Basic-Clinical Oncology (DOBC), Faculty of Medicine, University of Chile, Santiago 8350499, Chile.

Colorectal cancer is a common disease, both in Chile and worldwide. The most widely used chemotherapy schemes are based on 5-fluorouracil (5FU) as the foundational drug (FOLFOX, CapeOX). Genetic polymorphisms have emerged as potential predictive biomarkers of response to chemotherapy, but conclusive evidence is lacking.

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Background: The collection of blood cultures (BC) is key for guiding antimicrobial therapy in children with febrile neutropenia (FN), more than 90% have central venous catheters (CVC). There is no consensus on the need for peripheral BC over central BC in this population. The aim of this study was to determine the contribution of peripheral BC over central BC in the diagnosis of bloodstream infections in children with FN.

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Article Synopsis
  • * In 2021, experts from 13 countries in the region gathered to address vaccination challenges and propose strategies to prevent the return of vaccine-preventable diseases.
  • * Suggested strategies for increasing vaccination coverage include using combination vaccines, enhancing surveillance, improving school engagement, promoting vaccine education and equity, and fostering collaborations among medical societies.
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Universal congenital cytomegalovirus (cCMV) screening in saliva is increasingly recommended. The aim of our study was to correlate the performance of a point-of-care rapid molecular test with CMV real time PCR (CMV RT-PCR) detection, using saliva pool-testing in newborns under a universal screening strategy. Saliva swabs were prospectively collected from newborns < 21 days old and tested by Alethia-LAMP-CMV assay in pools of 5 samples.

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Objectives: To characterize the nutritional status of children admitted to Latin American (LA) PICUs and to describe the adequacy of nutrition support in reference to contemporary international recommendations.

Design: The Nutrition in PICU (NutriPIC) study was a combined point-prevalence study of malnutrition carried out on 1 day in 2021 (Monday 8 November) and a retrospective cohort study of adequacy of nutritional support in the week preceding.

Setting: Four-one PICUs in 13 LA countries.

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