575 results match your criteria: "Hospital La Paz Institute for Health Research - IdiPAZ[Affiliation]"

This study assessed the feasibility and security of remote surgical wound monitoring using the RedScar© smartphone app, which employs automated diagnosis for early visual detection of infections without direct healthcare personnel involvement. Additionally, patient satisfaction with telematic care was evaluated as a secondary aim. Surgical site infection (SSI) is the second leading cause of healthcare-associated infections (HAIs), leading to prolonged hospital stays, heightened patient distress, and increased healthcare costs.

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Background And Purpose: Endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) with M2 segment occlusion of the middle cerebral artery (MCA) is debatable. This study assessed the efficacy, safety, and functional outcomes of EVT in M2 occlusion patients, examining differences in outcomes based on the dominance of the occluded segment (DomM2 vs. Non-DomM2).

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Impact of malnutrition on the clinical evolution in a cohort of older patients undergoing emergency surgery for abdominal pathology.

Rev Esp Geriatr Gerontol

December 2024

Department of Geriatrics, La Paz University Hospital, Madrid, Spain; Hospital La Paz Institute for Health Research (IdiPAZ), La Paz University Hospital - Universidad Autónoma de Madrid, Madrid, Spain; Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.

Purpose: Analyse the influence of the nutritional status of older patients undergoing emergency abdominal surgery on postoperative complications, mortality and mean length of hospital stay.

Methods: We performed a longitudinal observational study including patients older than 80 years who underwent emergency surgery by the general surgery service for abdominal pathology, who were followed by the geriatrics service between September 2018 and May 2021. Malnutrition was diagnosed using Global Leadership Initiative on Malnutrition (GLIM) criteria, classifying patients as malnourished and normonourished.

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Objectives: This study aimed to assess the prevalence and risk factors associated with disease-related malnutrition (DRM) in hospitalized patients using the Subjective Global Assessment (SGA) and Global Leadership Initiative on Malnutrition (GLIM) criteria. Additionally, we sought to identify key determinants of moderate and severe malnutrition.

Methods: A retrospective analysis was conducted on 1036 adult patients hospitalized in a tertiary care hospital between August 2019 and November 2020.

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Maple syrup urine disease (MSUD) is a rare inherited metabolic disorder characterized by deficient activity of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex, required to metabolize the amino acids leucine, isoleucine, and valine. Despite its profound metabolic implications, the molecular alterations underlying this metabolic impairment had not yet been completely elucidated. We performed a comprehensive multi-omics integration analysis, including genomic, epigenomic, and transcriptomic data from fibroblasts derived from a cohort of MSUD patients and unaffected controls to genetically characterize an MSUD case and to unravel the MSUD pathophysiology.

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Uncovering cellular senescence as a therapeutic target in NF2-related vestibular schwannoma.

Hear Res

January 2025

Neuropathology of Hearing and Myelinopathies Group. Institute for Biomedical Research Sols-Morreale, Spanish National Research Council, Autonomous University of Madrid (CSIC-UAM), 28029 Madrid, Spain; Hospital La Paz Institute for Health Research (IdiPAZ), 28046 Madrid, Spain. Electronic address:

Background: Vestibular schwannomas (VS) are complex and heterogeneous human tumors arising from the Schwann cell compartment of the vestibulocochlear nerve. VS cause significant neurological deficit such as hearing loss and vestibular impairment, and in some cases death due to brainstem compression. There is an urgent need to find pharmacotherapies for VS since surgical removal and stereotactic radiosurgery are the only effective treatments.

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Introduction: People with a migratory background often face traumatic experiences increasing the risk of mental health problems and substance use. It is important to gain a greater understanding of the perspectives of substance use among North African young people with a migratory background and social agents.

Methodology: A qualitative phenomenological study was conducted.

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Background: The increasing availability of neuroimaging tests has led to a rise in the identification of incidental unruptured intracranial aneurysms (UIAs). Their management is under debate, with no consensus on their follow-up strategy, which can cause anxiety in patients. Our aim is to evaluate the impact of diagnosis and imaging follow-up on daily activities and quality of life.

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Biological drugs for the treatment of children with chronic spontaneous urticaria.

Expert Rev Clin Immunol

December 2024

Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Introduction: There is a significant prevalence of chronic spontaneous urticaria (CSU) in children across the globe. Some children with CSU do not achieve disease control with first-line antihistamine treatment and may need anti-IgE therapy with omalizumab. Recently, several novel treatment options, including dupilumab and BTK inhibitors, showed promising results in the treatment of antihistamine-refractory CSU in adults.

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Background: Historically, perinatal depression has predominantly focussed on the mother-baby dyad, often neglecting the crucial role of fathers.

Aim: To determine the prevalence and associated factors of depressive symptoms in the immediate puerperium (PDS) in both mothers and fathers, individually and concurrently.

Method: This study employed a cross-sectional design.

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The blood enzyme glutamate-oxaloacetate transaminase (GOT) has been postulated as an effective therapeutic to protect the brain during stroke. To demonstrate its potential clinical utility, a new human recombinant form of GOT (rGOT) was produced for medical use. We tested the pharmacokinetics and evaluated the protective efficacy of rGOT in rodent and non-human primate models that reflected clinical stroke conditions.

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Rapid identification of pathogens in acute meningitis is critical for timely treatment. However, traditional methods often face limitations in differentiating closely related species such as Streptococcus pneumoniae and Streptococcus pseudopneumoniae. We report a case of community-acquired meningitis caused by S.

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Article Synopsis
  • A comprehensive understanding of the healthcare system and neurology departments is essential for effectively implementing anti-amyloid antibody treatments in hospitals, especially regarding the organization and patient care.* -
  • A survey of department heads from 16 Spanish hospitals showed consensus on the need for structural changes, such as focusing Alzheimer’s patients in specialized dementia units and expanding neurology services by hiring more staff and enhancing diagnostic procedures.* -
  • The findings underscore the necessity for significant transformations in Spanish neurology departments to ensure the successful integration of anti-amyloid antibodies and promote fair access to new therapies for patients.*
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Article Synopsis
  • A study aimed to evaluate the outcomes of prehabilitation in elderly patients (80+) undergoing colorectal cancer surgery at a tertiary hospital from 2018 to 2022.
  • Out of 184 patients, 126 underwent surgery, revealing high frailty rates in octogenarians (50%) and nonagenarians (86%) and recorded a low rate of post-surgical complications and mortality.
  • Prehabilitation included physical exercise, nutritional support, and other treatments, showing that prehabilitation for very old patients can yield positive results in surgical settings.
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Objectives: We assessed the opinions of physicians caring for people with HIV (PWH) from the multicentre Spanish CoRIS cohort regarding the assessment of health-related quality of life (HRQoL).

Methods: We designed an online self-administered questionnaire comprising 27 structured questions across four domains: (i) sociodemographic and clinical data; (ii) usefulness of measuring HRQoL; (iii) information, training and resource needed; and (iv) whether and how HRQoL should be measured. Physicians completed the questionnaire between April and June 2023.

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Article Synopsis
  • A study aimed at understanding colorectal cancer (CRC) biology identified early diagnostic markers through quantitative proteomics of tissue samples from patients with stage I sporadic CRC.
  • Two experiments using advanced mass spectrometry techniques revealed 2,681 proteins, with 284 upregulated and 280 downregulated in adenoma and adenocarcinoma tissues compared to healthy samples.
  • Further investigation of ten dysregulated proteins showed that SLC8A1 and TXNDC17 are crucial for CRC development and could serve as potential early diagnostic markers in plasma tests.
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Proteomic identification of allergenic proteins in holm oak (Quercus ilex) seeds.

Food Chem

February 2025

Agroforestry and Plant Biochemistry, Proteomics, and Systems Biology Research Group, Department of Biochemistry and Molecular Biology, University of Córdoba, Córdoba, Spain. Electronic address:

Humans have used Quercus ilex acorns as a staple food since ancient times. Recently, their nutritional and nutraceutical value has revived interest for human consumption. Ensuring their safety as food requires assessing their allergenic potential.

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Background/objectives: Dysgeusia contributes to the derangement of nutritional status in patients with cancer as well as worsening the quality of life. There has been a lack of effective treatments for taste disorders provided by the pharmaceutical industry.

Methods: This was a pilot randomized, parallel, triple-blind, and placebo-controlled intervention clinical trial in which 31 malnourished patients with cancer and dysgeusia receiving antineoplastic treatment were randomized into three arms [standard dose of DMB (150 mg DMB/tablet), high dose of DMB (300 mg DMB/tablet) or placebo (300 mg freeze-dried strawberry)] for three months.

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Multiple sclerosis (MS) remains the leading cause of neurological disability among young adults worldwide, underscoring the urgent need to define the best therapeutic strategy. Recent advances in proteomics have deepened our understanding of treatment mechanisms and revealed promising biomarkers for predicting therapeutic outcomes. This study focuses on the identification of a protein profile of circulating extracellular vesicles (EVs) derived from neurons, oligodendrocytes, and B and T cells able to differentiate treatment responders and non-responders in 80 patients with MS.

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