117 results match your criteria: "Hospital Infantil Sabara[Affiliation]"

Background: Meningiomas are rare tumors in children compared with adults. Their main peculiarities are the frequent convexity or intraventricular location, the common association with neurofibromatosis-2 (NF-2) and the relatively high rate of aggressive and/or hyperostotic variants. Hyperostosis may complicate the surgical management.

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Background/objectives: Fats, although essential for the proper functioning of the body, have been linked to an increased risk of developing chronic diseases, especially cardiovascular disease. The aim of this study was to evaluate the intake of total fat and its components (saturated, monounsaturated, polyunsaturated, and trans fats) in men and women aged 15 to 65 years of the urban population in eight Latin American countries.

Methods: Survey data were collected from the Latin American Study of Nutrition and Health (ELANS, by its acronym in Spanish), an epidemiological study, including 9218 subjects from Argentina, Brazil, Chile, Colombia, Costa Rica, Ecuador, Peru, and Venezuela.

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Introduction: water is a crucial component of human health useful for various bodily functions. Despite its importance, previous research has largely overlooked hydration in Latin America, focusing instead on regions with greater access to a variety of food sources. Objective: hence, this study provides comprehensive data on water consumption patterns in this region and analyses the hydration profiles of urban Latin American populations, emphasizing the role of pure water in daily intake.

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GOOD CORRELATION BETWEEN LIVER STIFFNESS MEASUREMENT AND APRI, FIB-4, PLATELET COUNT, IN PEDIATRIC AUTOIMMUNE HEPATITIS.

Arq Gastroenterol

October 2024

Faculdade de Ciências Médicas da Universidade Estadual de Campinas, Departamento de Pediatria, Campinas, SP, Brasil.

Article Synopsis
  • The study investigates the effectiveness of non-invasive liver fibrosis markers, such as APRI and FIB-4, in children with autoimmune hepatitis, given the risks associated with liver biopsies.
  • A total of 28 pediatric patients were divided based on liver stiffness measurement (LSM) using transient liver elastography, with 71% showing significant fibrosis (≥F2).
  • Results indicate that there is a strong correlation between LSM and the serum markers APRI, FIB-4, and platelet count, suggesting they can be reliable indicators of liver fibrosis severity in this population.
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Background/objectives: Choline and essential fatty acids (EFA) are vital for fetal brain development, supporting pregnancy, and maintaining hormonal balance. They also promote overall health. The childbearing years present a window of opportunity to increase the intake of these key nutrients and develop healthy dietary habits.

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Article Synopsis
  • Spinal muscular atrophy (SMA) is a severe neuromuscular disorder leading to muscle weakness and reduced life expectancy, with onasemnogene abeparvovec being the first approved gene therapy for it.
  • A study involving 41 SMA patients (mostly type 1) showed significant motor function improvement after gene therapy, with nearly half of the type 1 patients gaining the ability to sit independently.
  • Adverse effects were common, including liver enzyme elevation in 70.7% of patients and thrombocytopenia in 31.7%, while the presence of previous nusinersen treatment didn't further enhance motor function post-gene therapy.
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Congenital heart disease (CHD) affects eight to ten out of every 1,000 births, resulting in approximately 23,057 new cases in Brazil in 2022. About one in four children with CHD requires surgery or other procedures in the first year of life, and it is expected that approximately 81% of these children with CHD will survive until at least 35 years of age. Professionals choosing to specialize in CHD surgery face numerous challenges, not only related to mastering surgical techniques and the complexity of the diseases but also to the lack of recognition by medical societies as a separate subspecialty.

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Minimally invasive repair of pectus carinatum (MIRPC) has been performed using the Abramson technique in which the bar that compresses the sternum is fixed with steel wires on the ribs. A 14-year-old patient underwent to a MIRPC using a sandwich technique in which two metallic bars fixed with bridges were implanted below the sternum under thoracoscopic vision, and another bar in a subcutaneous tunnel was implanted above. This technique has the potential to avoid specific problems related to the original technique like loosening of support for correction (broken wire), avoidance of induction of pectus excavatum or subcutaneous tissue adhesion.

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Objective: To report the need for cord untethering after prenatal repair of open spina bifida using a unique biocellulose-based technique performed at a later gestational age.

Methods: An observational cohort study was conducted to determine the incidence of tethered cord syndrome. Between May 2013 and May 2022, we performed 172 procedures using the percutaneous fetoscopic approach in fetuses at 26-28 weeks of gestation.

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Excessive intake of free sugars is associated with adverse health outcomes. Table sugar is one of the main dietary sources of free sugars; however, the amount added by Brazilian consumers in their culinary preparations is unknown. The aims were to estimate the daily intake of table sugar (g/day), its contribution to total energy intake (E%) and the main food groups that contribute to the intake of this sugar in a nationwide multi-ethnic sample of Brazilian adults (2017-2018 Brazilian National Dietary Survey).

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Energy imbalance gap was associated with body mass index and sex in Latin American adolescents-results from the ELANS study.

Front Nutr

March 2024

Centro de Excelencia em Nutrição e Dificuldades Alimentaes (CENDA), Instituto Pensi, Fundação José Luiz Egydio Setubal, Hospital Infantil Sabará, São Paulo, Brazil.

Introduction: Energy imbalance gap (EIG) is defined as the average daily difference between energy intake (EI) and energy expenditure (EE). This study aimed to examine the associations between EIG and sociodemographic and anthropometric variables in the adolescent population of eight Latin America countries.

Methods: A total of 680 adolescents aged 15 to 18 were included in this study.

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Randomized comparison of oblique and perpendicular stabilizers for minimally invasive repair of pectus excavatum.

Interdiscip Cardiovasc Thorac Surg

March 2024

Divisao Cirurgia Toracica, Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Objectives: Bar dislocation is one of the most feared complications of the minimally invasive repair of pectus excavatum.

Methods: Prospective randomized parallel-group clinical trial intending to assess whether oblique stabilizers can reduce bar displacement in comparison with regular stabilizers used in minimally invasive repair of pectus excavatum. Additionally, we evaluated pain, quality of life and other postoperative complications.

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Assessing dietary inadequacies can contribute to understanding the nutritional vulnerabilities of a country. This study aimed to investigate nutrient intakes and micronutrient inadequacies in the Brazilian adult population, with an interest in different age subgroups. We conducted a cross-sectional study with 1812 individuals aged 19 to 65 years from a population-based study with a representative sample of Brazilian adults.

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Article Synopsis
  • - The study evaluated the use of whole genome sequencing (WGS) as a first-step diagnostic tool for critically ill infants in Brazilian neonatal intensive care units, with collaboration between private and public hospitals.
  • - In a cohort of 21 infants suspected of genetic diseases, WGS provided a diagnostic yield of 57%, identifying various genetic variants, including 10 novel ones not found in existing databases.
  • - The research highlighted the advantages of WGS over traditional genetic tests in diagnosing conditions like dysmorphic syndromes while also discussing the challenges and potential implications of integrating WGS into Brazil's healthcare system.
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Recommendations from the Brazilian Society of Anesthesiology (SBA) for difficult airway management in pediatric care.

Braz J Anesthesiol

February 2024

Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu (FMB), Departamento de Especialidades Cirúrgicas e Anestesiologia, Botucatu, SP, Brazil. Electronic address:

Difficult airway management in pediatrics during anesthesia represents a major challenge, requiring a careful approach, advanced technical expertise, and accurate protocols. The task force of the Brazilian Society of Anesthesiology (SBA) presents a report containing updated recommendations for the management of difficult airways in children and neonates. These recommendations have been developed based on the consensus of a panel of experts, with the objective of offering strategies to overcome challenges during airway management in pediatric patients.

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Article Synopsis
  • * Conducted in April and June 2019, it analyzed data from 27 out of 738 pediatric intensive care units, finding that 74% of patient-days included therapist-provided mobility.
  • * Key factors influencing mobility included increased family presence, which improved out-of-bed activities, while barriers like lack of physician orders hindered mobilization on 27% of patient-days.
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Background: Brazil´s case fatality rate (CFR) of pediatric multisystem inflammatory syndrome in children and adolescents (MIS-C) is among the highest worldwide. Despite these concerns, limited hospital-based and comprehensive pediatric data have been published on MIS-C in Brazilian children.

Methods: We performed a descriptive analysis of the MIS-C scores in 16 public and private hospitals providing secondary and tertiary care in the metropolitan area of São Paulo, Brazil.

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Objectives: To determine if the lower-extremity neurological motor function level in fetuses with open spina bifida deteriorates within the 4-week interval between a first prenatal motor assessment at around 22 weeks of gestation and a second evaluation, prior to 'late' prenatal surgery, defined as surgery at 26-28 weeks and, in certain situations, up to 30 weeks, and to assess the association between prenatal presurgical motor-function level, anatomical level of the lesion and postnatal motor-function level.

Methods: This was a two-center cohort study of 94 singleton fetuses with open spina bifida which underwent percutaneous repair using the skin-over-biocellulose for antenatal fetoscopic repair (SAFER) technique between December 2016 and January 2022. All women underwent two prenatal systematic ultrasound evaluations, approximately 4 weeks apart, with the second one being performed less than 1 week before surgery, and one postnatal evaluation via physical examination within 2 months of birth.

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Introduction: Despite preventive strategies, vomiting is an adverse event affecting patients with cancer. However, literature on the incidence and risk factors for vomiting in pediatric patients with cancer are scarce.

Aim: To assess the incidence and risk factors for vomiting within 24 h and goodness of fit for the Eberhart score in pediatric patients with hematologic cancers after receiving intrathecal chemotherapy under deep sedation.

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Article Synopsis
  • A study analyzed COVID-19 severity in hospitalized children across nine countries, focusing on the impact of different SARS-CoV-2 variants over time.
  • It found that children younger than 5 years showed a decrease in ICU admissions during the Omicron wave compared to the earlier variants, but ventilatory support needs remained unchanged.
  • In older children (5 to <18 years), there was a significant decrease in ICU admissions, ventilatory support, and oxygen therapy requirements as new variants emerged.
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Objectives: To identify factors associated with prolonged mechanical ventilation (pMV) in pediatric patients in pediatric intensive care units (PICUs).

Design: Secondary analysis of a prospective cohort.

Setting: PICUs in centers that are part of the LARed Network between April 2017 and January 2022.

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Obesity is a chronic disease resulting from multifactorial causes mainly related to lifestyle (sedentary lifestyle, inadequate eating habits) and to other conditions such as genetic, hereditary, psychological, cultural, and ethnic factors. The weight loss process is slow and complex, and involves lifestyle changes with an emphasis on nutritional therapy, physical activity practice, psychological interventions, and pharmacological or surgical treatment. Because the management of obesity is a long-term process, it is essential that the nutritional treatment contributes to the maintenance of the individual's global health.

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