3 results match your criteria: "Hospital Group Twente (Ziekenhuisgroep Twente)[Affiliation]"
Investigating interferon type I responses in patients with suspected giant cell arteritis and polymyalgia rheumatica.
Clin Exp Immunol
November 2024
Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Article Synopsis
- Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are inflammatory diseases, and researchers are looking for biomarkers to identify active cases and those who may need alternative treatments to glucocorticoids.
- A study evaluated the presence of interferon type I (IFN-I) markers in GCA and PMR patients, including those not previously treated, but did not find significant differences in IFN-I scores between these groups and healthy controls.
- The results indicated that the IFN-I signature and serum markers CXCL10 and Galactin-9 were not elevated in patients with GCA or PMR, suggesting that these IFN-I markers may not be useful for diagnosing or guiding treatment
A direct comparison in diagnostic performance of CDUS, FDG-PET/CT and MRI in patients suspected of giant cell arteritis.
Rheumatology (Oxford)
April 2024
Department of Rheumatology and Clinical Immunology, Hospital Group Twente (Ziekenhuisgroep Twente), Almelo, the Netherlands.
Objectives: This study directly compares diagnostic performance of Colour Duplex Ultrasound (CDUS), Fluor-18-deoxyglucose Positron Emission Tomography Computed Tomography (FDG-PET/CT) and Magnetic Resonance Imaging (MRI) in patients suspected of giant cell arteritis (GCA).
Methods: Patients with suspected GCA were included in a nested-case control pilot study. CDUS, whole body FDG-PET/CT and cranial MRI were performed within 5 working days after initial clinical evaluation.
Evidence for increased interferon type I activity in CD8+ T cells in giant cell arteritis patients.
Front Immunol
July 2023
Department of Rheumatology and Clinical Immunology, Hospital Group Twente (Ziekenhuisgroep Twente), Almelo, Netherlands.
Introduction: Giant cell arteritis (GCA) is a vasculitis of the medium- and large-sized arteries. Interferon type I (IFN-I) is increasingly recognized as a key player in autoimmune diseases and might be involved in GCA pathogenesis, however evidence is limited. IFN-I activates Janus kinase/signal transducers and activators of transcription (JAK-STAT) pathways, leading to increased expression of interferon stimulated genes.
View Article and Find Full Text PDF