3,238 results match your criteria: "Hospital Germans Trias i Pujol.[Affiliation]"

Article Synopsis
  • * Bosutinib has been proven effective in inducing sustained molecular responses, even in advanced stages of CML, making it suitable for second- and later-line therapies.
  • * Its favorable safety profile, particularly the low occurrence of vascular complications, positions bosutinib as a strong option for optimizing treatment in CML, especially for patients intolerant or resistant to other TKIs.
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Purpose: The ETOP 10-16 BOOSTER study was a randomized phase II trial of osimertinib and bevacizumab therapy versus osimertinib therapy in patients with an acquired EGFR T790M mutation. The mechanisms of acquired resistance to osimertinib and bevacizumab have not been described previously.

Experimental Design: Next-generation sequencing (Guardant360) was conducted in serial plasma samples.

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Purpose Of Review: The use of immunotherapy in recent years has changed the paradigm of treatment in patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL), improving outcomes in the relapsed/refractory setting. New strategies are incorporating immunotherapy into front-line regimens to reduce the toxicity of chemotherapy, prolong survival and increase the possibility of treating older patients. The aim of this review was to describe the new strategies, which have incorporated these drugs into front-line regimens for BCP-ALL patients.

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Article Synopsis
  • - A randomized trial showed that adding delayed enhancement MRI-guided fibrosis ablation to pulmonary vein isolation (PVI) for treating atrial fibrillation (AF) didn’t improve outcomes, with similar recurrence rates between the two methods.
  • - The study analyzed how effectively lesions delivered during ablation covered fibrotic areas, finding that a much higher percentage of targeted fibrosis was successfully ablated using MRI guidance compared to PVI alone.
  • - While overall scar coverage didn’t significantly reduce AF recurrence, lower recurrence rates were noted in patients with less baseline fibrosis when fibrosis-targeted ablation was used, indicating variability in treatment effectiveness.
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This study generated evidence to guide anticoagulation in patients with VTE after vaccination for COVID-19. We provided data on the low recurrence rate after cessation of anticoagulant therapy and the findings for this study offer timely insights into the management of a potentially vaccine-related adverse event.

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Native vitamin D in CKD and renal transplantation: meaning and rationale for its supplementation.

J Nephrol

July 2024

Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

Article Synopsis
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Introduction: People with the human immunodeficiency virus (PWH) who were diagnosed long ago are more prone to age-related conditions and comorbidities than the general population. We hypothesized that older PWH have endocrine abnormalities that may influence the patient's health status.

Methods: Mean hormonal values across the thyrotropic, somatotropic, corticotropic, and gonadal axis, and percentage of subjects with abnormal values, were compared between PWH aged ≥50 years (n=30) and people without HIV (n=30) (Over50 cohort).

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Article Synopsis
  • Understanding how immune cells work after a kidney transplant can help doctors manage patients better and prevent rejection.
  • This study focused on a special type of B cell called transitional B cells, which might help predict if a transplant will succeed.
  • Results showed that having more transitional B cells after surgery was linked to better health for the transplant and fewer rejection problems, which could lead to better treatments for patients.
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Impact of gender on in-hospital and long-term outcomes after transcatheter aortic valve implantation: an analysis of the Spanish TAVI registry.

Rev Esp Cardiol (Engl Ed)

August 2024

Hospital Clínic, Institut Clínic Cardiovascular, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.

Introduction And Objectives: Impact of gender on long-term outcomes after transcatheter aortic valve implantation (TAVI) remains uncertain. We aimed to investigate gender-specific differences in TAVI and its impact on outcomes.

Methods: This analysis used data from the prospective Spanish TAVI registry, which included consecutive TAVI patients treated in 46 Spanish centers from 2009 to 2021.

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Background And Hypothesis: Young adults starting kidney replacement therapy (KRT) during childhood and reaching their 18th birthday (i.e. adult survivors of childhood KRT) form a challenging population of interest to nephrologists treating adults, as during this period there will be a transition to adult renal centres.

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Article Synopsis
  • - The study aimed to understand the natural history and prognostic factors of porto-sinusoidal vascular disorder (PSVD) by analyzing a large cohort of 587 patients across 27 centers, finding that the majority were asymptomatic at diagnosis, but many experienced complications related to portal hypertension.
  • - Over a median follow-up of 68 months, 8.5% of patients underwent liver transplantation, while 19% died, highlighting significant risks like portal hypertension-related bleeding and ascites, as well as the impact of age and liver function on prognosis.
  • - The findings indicate that the severity of underlying conditions and liver/renal function significantly influence survival chances, leading to the development of a nomogram for more accurate prognosis prediction in
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H-FABP as a Biomarker in Transient Ischemic Attack.

J Cardiovasc Transl Res

August 2024

Neurovascular Research Laboratory Vall d'Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.

Article Synopsis
  • The study examines the effectiveness of heart fatty-acid binding protein (H-FABP) in differentiating transient ischemic attacks (TIA) from similar conditions using data from 175 patients.
  • Results showed higher H-FABP levels in TIA patients compared to mimic cases, with a significant p-value indicating a strong difference.
  • H-FABP demonstrated good diagnostic capabilities, with a sensitivity of 100% and specificity of 23.30%, suggesting its potential as a useful biomarker for TIA in clinical settings like emergency departments.
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Article Synopsis
  • Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease linked to abnormal tau protein accumulation, and previous studies were limited in exploring rare genetic variants due to the use of genotype arrays.* -
  • In this study, whole genome sequencing (WGS) on a large cohort allowed researchers to confirm known genetic loci related to PSP and discover new associations, particularly highlighting a different role for the APOE ε2 allele compared to Alzheimer's disease.* -
  • The findings expand knowledge of PSP's genetic underpinnings and identify potential targets for future research into the disease's mechanisms and treatments.*
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Article Synopsis
  • * The study identified 8 strain types of HD, including 7 new Class I strains, and found that the southern region had the least genetic diversity, primarily showing Class II infections.
  • * Analysis indicated that Class II infections lead to longer-lasting ulcers compared to Class I, with an increase in the I.10 strain observed after azithromycin treatment in patients.
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Article Synopsis
  • Atrial functional mitral regurgitation (AFMR) is under-researched, leading to a need for understanding its prevalence, characteristics, and treatment outcomes.
  • A study conducted across 26 Japanese medical centers reviewed echocardiography data from 177,235 patients, identifying 1,007 cases of AFMR, predominantly in older adults, with a significant portion also having atrial fibrillation.
  • Among AFMR patients, 113 underwent mitral valve surgery, often alongside tricuspid valve intervention, revealing that these patients had more severe mitral regurgitation and higher associated heart failure rates compared to those who did not have surgery.
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Background: Levodopa-induced dyskinesia (LID) is a common adverse effect of levodopa, one of the main therapeutics used to treat the motor symptoms of Parkinson's disease (PD). Previous evidence suggests a connection between LID and a disruption of the dopaminergic system as well as genes implicated in PD, including GBA1 and LRRK2.

Objectives: Our goal was to investigate the effects of genetic variants on risk and time to LID.

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