Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode.

Background & Aims: Alcohol-related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis.

Identifying SARS-CoV-2 'memory' NK cells from COVID-19 convalescent donors for adoptive cell therapy.

COVID-19 disease is the manifestation of syndrome coronavirus 2 (SARS-CoV-2) infection, which is causing a worldwide pandemic. This disease can lead to multiple and different symptoms, being lymphopenia associated with severity one of the most persistent. Natural killer cells (NK cells) are part of the innate immune system, being fighting against virus-infected cells one of their key roles.

SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell Therapy.

Syndrome coronavirus 2 (SARS-CoV-2) pandemic is causing a second outbreak significantly delaying the hope for the virus' complete eradication. In the absence of effective vaccines, we need effective treatments with low adverse effects that can treat hospitalized patients with COVID-19 disease. In this study, we determined the existence of SARS-CoV-2-specific T cells within CD45RA memory T cells in the blood of convalescent donors.

Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming.

Snakebite envenoming is a global neglected disease with an incidence of up to 2.7 million new cases every year. Although antivenoms are so-far the most effective treatment to reverse the acute systemic effects induced by snakebite envenoming, they have a limited therapeutic potential, being unable to completely neutralize the local venom effects.

[Treatment of refractory hepatic encephalopathy associated with insertion of a transjugular intrahepatic portosystemic shunt through new endovascular techniques: a case report].

Insertion of a transjugular intrahepatic portosystemic shunt (TIPS) is an increasingly used treatment in the management of the complications of portal hypertension. However, one of the complications of this technique is refractory or recurrent hepatic encephalopathy, which poses a difficult clinical problem. We report the case of a patient who underwent TIPS insertion to control bleeding due to esophageal varices.

[Current problems in the prevention and treatment of infections in patients with cirrhosis].

Infections in patients with cirrhosis are a common complication causing substantial morbidity and mortality. Bacterial translocation plays an important role in the pathogenesis of many infections in cirrhosis. In turn, infections are involved in the pathogenesis of many episodes of decompensated cirrhosis, such as esophageal variceal bleeding, renal insufficiency, the hemodynamic alterations of cirrhosis, and hepatic encephalopathy.

Colonic wall thickening in patients with cirrhosis and portal hypertension.

Objective: To determine the prevalence of colonic wall thickening (CWT) and its relation with other clinical and radiological findings of portal hypertension.

Experimental Design: Retrospective observational study. The follow-up period was at least 1 year.

[Solitary plasmacytoma of the head and neck. Report of 3 cases and review of the literature].

Solitary plasmocytoma is a rare plasmactic cell tumor occurring in the head and neck. These constitute, less than 1% of all head and neck malignancies. On initial presentation they must be differentiated from multiple myeloma.

[Descriptive study of infectious ear disease in relation to summer].

A descriptive study was made of infectious ear disease (including diffuse otitis externa, otomycosis, acute-on-chronic otitis media, and superinfection of a radical mastoidectomy cavity) in relation to changes of weather and habits in summer. During the months of June, July, and August 1996, 179 patients were evaluated in the emergency room of the Alicante General University Hospital, Spain. Average patient age at presentation was 30.

[Giant calcifications of a double-J ureteral catheter].

We present a case of recurring gigantic calcifications of both extreme of a double-J ureteral catheter, with long permanency of the same. We expose the technical maneuvers that were specified for the managing of so important complication. We emphasize the renal functional conservation found in spite of the magnitude of the calcifications.

[Intestinal obstruction secondary to endometriosis of the colon].

Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity. Although in most cases it is a benign disorder, it may be aggressive producing local invasion and even metastasis. Endometrial implantation has been reported in many organs including the small and large intestine leading to acute or chronic symptomatology.

[Protocol for sino-nasal tumors in our service].

Tumors of the nasal fossa and paranasal region are uncommon and have non-specific initial clinical features. This complicates the diagnosis and delays treatment. We reviewed all our cases of nasal sinus tumors (84 benign, 50 malignant and 15 moderately malignant) and the relevant literature.

[Prevalence of migraine in a homogeneous population using the self-questionnaire 'Alcoi-1995'].

Introduction: There are numerous studies of the prevalence of migraine and very varied findings. Amongst the many reasons for this would seem to be the use of questionnaires for screening populations, absent or incorrect validation of these questionnaires and the use of impracticable diagnostic criteria.

Objective: To determine the prevalence of migraine in a homogeneous population using the self-questionnaire 'Alcoi 1995' which had previously been validated for the diagnosis of migraine.

[Validity and reliability of the migraine self-questionnaire Alcoi-1995].

Introduction: In epidemiological investigation valid, reliable means of diagnosing the illnesses studies are essential.

Objective: To validate the self-questionnaire 'Alcoi 1995' for the diagnosis of migraine.

Methods: We used the questionnaire Alcoi-1992 (which had been validated previously) to find the prevalence of migraine in homogeneous populations.

[Esophageal Crohn's disease].

Crohn's disease is characterized by chronic inflammation of the digestive tract which may be localized at any level. Nonetheless, esophageal disease is infrequent. Two cases of esophageal involvement in this disease in 2 young women with a history of previous involvement at an intestinal level are presented.

[Functional surgery versus radical surgery in carcinoma of the hypopharynx].

A retrospective study was made of the clinical features and effectiveness of different surgical techniques in 66 patients with carcinoma of the hypopharynx treated at our hospital between 1985 and 1990. Thirty-seven patients were treated surgically and 29 were not. In the early stages, surgical treatment was functional: 15 patients had hemipharyngolaryngectomy or partial pharyngectomy.

[Cancer of the larynx in women. Presentation of 4 cases].

Four new cases of laryngeal carcinoma in the women are presented. The two first ones as glottic polyps, the third one as subglottic-tracheal and the fourth one as a submucous lesion of the ventricle with lowly growing. We see the treatment and the evolution.

[Supracricoid hemilaryngectomy].

The supracricoid laryngectomy is a surgical procedure clearly identifiable, deserving this denomination either in descriptive and differential sense. In the paper the AA. itemize the characteristics of the operation (concept, history, synonymy, the basic points of the technique) and the anatomopathologic fundamentals, even the results published in the literature.

[Adenoid cystic subglottic carcinoma. A case report].

A case of adenoid cystic carcinoma found in the laryngeal region (suglottically), extending as far as the trachea, four years postoperatively, has not yet shown signs of local recurrence nor of metastasis. The unusual features of this case are its site and favourable progress postoperatively. A study was made of the literature of this type of tumour.