Validation of the acute kidney injury "Standardized Clinical Assessment and Management Plan" (SCAMP) Spanish translation to guide initiation of kidney replacement therapy.

Background: Acute kidney injury (AKI) occurs in up to 50% of critically ill patients, often requiring kidney replacement therapy (KRT). The ideal time to start KRT is not fully standardized, and evidence stands controversial at this point. The overall prognosis of patients may be linked to the timing of KRT initiation.

Genomic and proteomic analyses of Nus-dependent non-lambdoid phages reveal a novel coliphage group prevalent in gut: mEp.

Introduction: Nus-dependent Mexican phages (mEp) were previously isolated from clinical samples of human feces. Approximately 50% corresponded to non-lambdoid temperate phages integrating a single immunity group, namely immunity I (mEp), and these were as prevalent as the lambdoid phages identified in such collection.

Methods: In this work, we present the structural and functional characterization of six representative mEp phages (mEp010, mEp013, mEp021, mEp044, mEp515, and mEp554).

Global epidemiology of acute kidney injury in hospitalised patients with decompensated cirrhosis: the International Club of Ascites GLOBAL AKI prospective, multicentre, cohort study.

Background: Acute kidney injury (AKI) is a serious complication of cirrhosis. A systematic, global characterisation of AKI occurring in patients with cirrhosis is lacking. We therefore aimed to assess global differences in the characteristics, management, and outcomes of AKI in hospitalised patients with cirrhosis.

Continuous sitting position during the postoperative period as an intervention to reduce risk of cerebrospinal fluid leak after endoscopic endonasal surgery.

Introduction/objectives: In recent decades, endoscopic endonasal surgery for skull base tumours has modified the way in which this region is approached. One of the most feared complications is the cerebrospinal fluid leak. It has been shown in different publications about CSF physiology that changes in the position modify the pressure of the CSF (pCSF).

Design and psychometric validation of a social capital questionnaire for adults with end-stage chronic kidney disease undergoing dialysis or hemodialysis.

Background: The effects of end-stage kidney disease (ESKD) can spill over into a patient's social life. Social capital (SC) is a determinant of health that can enhance patients' health through support and resources. However, no questionnaire is currently available to measure SC in ESKD patients.

miR-16-5p, miR-21-5p, and miR-155-5p in circulating vesicles as psoriasis biomarkers.

Psoriasis is a chronic skin disorder marked by fast skin cell growth, leading to thick, red, scaly patches. MicroRNAs are small, non-coding RNA molecules that play a crucial role in post-transcriptional gene regulation. This study investigates miR-16-5p, miR-21-5p, and miR-155-5p expression in psoriasis EVs and assesses their biomarker potential, exploring associated target genes and pathways via bioinformatics.

Microbiota Dysbiosis: A Key Modulator in Preeclampsia Pathogenesis and Its Therapeutic Potential.

Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality worldwide. Emerging evidence implicates gut and vaginal microbiota dysbiosis in preeclampsia pathogenesis through its roles in immune regulation, inflammation, and placental function. This review explores the mechanisms linking microbiota alterations to preeclampsia and evaluates the therapeutic potential of microbiota-targeted interventions.

Optimizing Electrodiagnostic Studies: The Role of Clinical History in Improving Diagnostic Concordance-A Retrospective Study.

Electrodiagnostic (EDx) studies are crucial for diagnosing neuromuscular diseases and are considered a complement to neurological examinations. Their effectiveness is highly dependent on the quality of the initial clinical diagnosis, medical history, and physical examination. This study aims to evaluate the concordance between clinical diagnoses and EDx findings, and to identify the primary specialties and clinical data justifying EDx referrals.

Eosinophilic esophagitis in children: A multicenter study evaluating current practices in Mexico.

Background: Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition characterized by eosinophil infiltration in the esophagus, leading to symptoms such as food impaction and growth delays. Despite its increasing recognition, there is significant variability in diagnostic and treatment practices, particularly in pediatric populations.

Objectives: This study aimed to evaluate the current diagnostic and treatment practices for EoE in children across multiple centers in Mexico, identify common clinical presentations, and assess the role of IgG in EoE.

Hypoxia inducible factor 3-alpha promotes a malignant phenotype in colorectal cancer cells.

Colorectal cancer (CRC) is the third most common cancer worldwide. Hypoxia is a hallmark of the tumor microenvironment, and cellular adaptation to it is primarily mediated by the family of Hypoxia-inducible factors (HIFs) HIF-1α, HIF-2α, and HIF-3α. However, in contrast to HIF-1α and HIF-2α, a specific role for HIF-3α in cancer biology has not yet been clearly established.

Relationship of Soft Tissue Thickness With Body Mass Index and Perioperative Factors in Patients Undergoing Total Hip Arthroplasty: A Retrospective Cross-Sectional Study.

Background Total hip arthroplasty is one of the most common elective procedures, making it crucial to minimize associated risks. The thickness of soft tissues at the surgical site is used to predict complications when evaluated individually. However, the direct relationship between soft tissue thickness, body mass index (BMI), and perioperative factors has not been established, making it necessary to determine this relationship to improve the prediction of complications using only standard radiographic measurements.

Bioelectrical impedance vector (BIVA) reference values for healthy term newborns 1-2 days old.

Background: Bioelectrical impedance vector analysis (BIVA) is a valuable tool for assessing individuals' body fluids and nutritional status by examining the impedance vector's position on the mean reference impedance vector tolerance ellipses from healthy populations. Nevertheless, differences in BIVA tolerance ellipses have been reported between populations with different ethnicities, body mass index (BMI), sex, and age.

Aim: To construct BIVA reference values for healthy newborns aged 1-2 days born to term and compare them to those previously reported for newborns from different populations.

Undernutrition risk and obesity increase the risk of osteosarcopenia in Mexican adults aged 50 and over: a prospective cohort study.

Introduction: Undernutrition risk in adults is a common but undiagnosed condition, while obesity is highly prevalent in this population. Osteosarcopenia is the coexistence of sarcopenia and osteopenia/osteoporosis and is related to higher morbidity and mortality. Undernutrition has been identified as an associated factor of osteosarcopenia; however, it is unknown whether undernutrition risk is also related to this condition.

Comparison of the Filamentous Fungi Library v4.0 MALDI Biotyper Platform vs MSI-2 performance for identifying filamentous fungi from liquid cultures.

Correct, rapid, and reliable filamentous fungi identification is crucial for timely diagnosis and therapy. We compared the performance of the FFLv4.0 MALDI Biotyper and MSI-2 to identify filamentous fungi from clinical isolates.

Triple Colonic Fistula Due to Complicated Diverticular Disease and Its Surgical Management.

Diverticular colon disease is the most common cause of colovesical fistulas, a rare and complex entity in their diagnosis and treatment. This report details the case of a 56-year-old patient who had presented with pneumaturia and gas in the vagina for six years and exudate in the abdominal wall in a midline wound. Given the suspicion, the diagnosis of the triple colonic fistula was confirmed by imaging studies: enteroatmospheric, colovesical, and colotubal, which were managed surgically.

Sexual and reproductive health from the perspective of patients with autoimmune rheumatic diseases in Mexico: a qualitative study.

Objectives: To explore the experiences and perspectives of female patients with autoimmune rheumatic diseases (ARDs) regarding sexual and reproductive health, including contraception, family planning, and pregnancy.

Design: Qualitative descriptive study using semi-structured interviews.

Setting: Specialised rheumatology clinic in a tertiary hospital in Monterrey, Mexico.

A New Anatomical Approach to Male Pectoral Volumization.

Background: In this article, we discuss a new technique of pectoralis major muscle volumization using ultrasound-guided fat grafting, considering a new surgical criterion that allows for larger volumes.

Methods: We present a retrospective observational descriptive study, which included men who underwent body contouring surgery during 2022-2023. As part of the study, measurements were taken before, immediately after, and at 3 months after surgery.

Personalized Photoprotection: Expert Consensus and Recommendations From a Delphi Study Among Dermatologists.

Background: Recommending comprehensive personalized photoprotection requires an accurate assessment of the patient's skin, including phototype, lifestyle, exposure conditions, environmental factors, and concomitant cutaneous conditions as well as deep knowledge of the available options: sunscreen ingredients (type of filters, spectrum coverage, sun protection factor, enhanced active ingredients), oral photoprotection, and other methods of sun protection and avoidance.

Objectives: To establish consensus-based recommendations endorsed by an international panel of experts for personalized medical photoprotection recommendations that are applicable globally.

Methods: A two-round Delphi study was designed to determine the degree of agreement and relevance of aspects related to personalized medical photoprotection.

Chronic mucocutaneous candidiasis, mycobacterial infections and rosacea in a Mexican adult with STAT1 gain of function.

STAT1 is a cytoplasmic transcription factor associated with cell growth regulation, differentiation, proliferation, metabolism, and apoptosis. IFN-mediated JAK/STAT signaling pathway is involved in eliminating intracellular pathogens and viruses. However, pathogenic variants in STAT1 can result in impaired or increased function.

Dyslipidemia: recommendations for diagnosis and treatment at the first level of medical contact.

Cardiovascular disease is the main cause of mortality in Mexico as well as the rest of the world, with dyslipidemia being one of the main risk factors. Despite the importance of its epidemiological impact, there is still -among primary care physicians- a lack of knowledge ranging from the basic concepts for diagnosis to the most recent recommendations for treatment. This document consisting of 10 questions is done by experts in this field.

Cross cultural adaptation and validation of audiovisual educational material for use in indigenous patients with rheumatoid arthritis.

Background: Culturally appropriate educational materials are necessary to improve health literacy among Indigenous populations. However, practically no such materials have been cross-culturally adapted and validated for Indigenous peoples based on compliance with efficacy components.

Objective: To perform a cross-cultural adaptation and validation of audiovisual educational materials for adult patients with rheumatoid arthritis belonging to Indigenous communities in Chiapas, Mexico.

Efficacy of bortezomib combined with Hyper-CVAD in adults with relapsed acute lymphoblastic leukemia or positive measurable residual disease; effect of bortezomib in leukemia.

Purpose: Despite advances in the treatment of adult acute lymphoblastic leukemia (ALL), relapse remains the most significant challenge in improving prognosis. Measurable residual disease (MRD) assessment can predict bone marrow relapse based on MRD positivity. As access to innovative therapies remains limited because of the high cost, chemotherapy is the widely utilized treatment option.

Update on actinomycetoma treatment: linezolid in the treatment of actinomycetomas due to spp and resistant to conventional treatments.

Introduction: Mycetoma is a chronic granulomatous infection, common throughout tropical regions, and is considered a neglected disease that mostly affects impoverished populations. Mycetoma is divided into eumycetoma, caused by fungi, and actinomycetoma, caused by filamentous bacteria. Clinical presentation is distinctive, and making the diagnosis is usually not difficult; however, access to safe and effective treatments is a major challenge.