[Characteristics of melanoma in Mexicans seen at "La Raza" National Medical Center].

Background: Melanoma is the third most common type of skin cancer in Mexico and represents 75% of skin cancer deaths. Dermoscopy is a diagnostic tool that increases early detection of melanoma compared to naked eye examination.

Objective: The aim of this study was to describe the clinical, dermoscopic and histological characteristics of patients with a confirmed diagnosis of cutaneous melanoma treated at the "La Raza" National Medical Center.

What Do We Currently Know About Chronic Myeloid Leukemia (CML) and COVID-19?

Purpose Of Review: COVID-19 is highly contagious; since it was first identified, the virus has rapidly spread to more than 100 countries and was declared a pandemic on March 11, 2020, by the World Health Organization (WHO). This disease presents several challenges when managing patients with leukemia. We review the information about chronic myeloid leukemia (CML) and COVID-19: risk factors, prognosis, and the role of tyrosine kinase inhibitors (TKIs).

Pneumothorax due to COVID-19: Analysis of case reports.

Cases of pneumothorax/pneumomediastinum have been reported in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, the time to onset and hospital stay have rarely been studied. Coronavirus disease 2019 (COVID-19) patients with these complications are described to determine the time to onset, associated comorbidities, and location and duration of pneumothorax. A search in PubMed yielded simple frequencies and a bivariate analysis of deaths.

[The role of public health ethics in the COVID-19 pandemic].

The purpose of this essay is to point out that the ethical principles in public health are based on the concepts of security and social solidarity of the Instituto Mexicano del Seguro Social (Mexican Institute for Social Security), ideas that Mexico contributed to the world in 1943. It is emphasized that the principlism model generates confusion to solve the ethical dilemmas that occur in the face of COVID-19 pandemic, and the pertinence of security, solidarity, ontic responsibility, diachonic responsibility as ethical principles of public health with orientation towards vulnerability is outlined, clarifying their correspondence in ethical behavior in the face of COVID-19 pandemic caused by the novel SARS-CoV-2 coronavirus.

[Immune thrombocytopenia secondary to COVID-19: a case report].

Background: The SARS-CoV-2 virus, which emerged in late 2019 in Wuhan province, China, has shown a wide spectrum of manifestations, some of which it shares with some autoimmune disorders. Until now, the association of SARS-CoV-2 with immune thrombocytopenia (ITP) is poorly understood, since the mechanisms that explain the complex relationship between these two prothrombotic states are still unknown.

Clinical Case: It is presented the case of a 66-year-old woman, with no chronic disease history, who arrived at the Emergency Department due to respiratory symptoms.

Bibliometric analysis of research reports: IMSS Southern Research Forum.

IntroducciÓn: La Coordinación de Investigación en Salud del Instituto Mexicano del Seguro Social promueve acciones para la realización del Foro Sur de Investigación en Salud del Instituto Mexicano del Seguro Social (FSIS-IMSS), entre las que destacan la presentación de reportes de investigación.

Objetivo: Analizar la actividad científica del FSIS-IMSS de 1995 a 2018 a través de los reportes de investigación publicados en el marco del Foro Sur.

Material Y MÉtodos: Estudio bibliométrico de los reportes de investigación publicados.

Utricular hypofunction in patients with type 2 diabetes mellitus.

The aim of this study was to assess the function of the utricle and horizontal semicircular canals in patients with type 2 diabetes mellitus receiving primary health care, with/without a history of falls. 101 patients with type 2 diabetes mellitus, 34 to 84 years old (26 with and 75 without a history of falls) and 51 healthy volunteers (40-83 years old) accepted to participate. They denied having a history of dizziness, vertigo, unsteadiness, hearing loss, or neurological disorders.

The association of subtypes of breast cancer with tumour characteristics and reproductive factors in 1326 Mexican women.

Aim Of The Study: In breast cancer, oestrogen receptor (ER), progesterone receptor (PgR), and HER2 (HER2/Neu) expression status are used to classify neoplasms into subtypes: Luminal A, Luminal B, HER2/Neu type, and Basallike. The aim of the present study was to establish the molecular subtypes of breast cancers and their association with tumour characteristics and reproductive factors in Mexican women.

Material And Methods: A total of 1326 biopsies of breast tumour tissues were analysed for ER, PR, and HER2/Neu by immunohistochemistry (IHC).

Arginase activity in patients with breast cancer: an analysis of plasma, tumors, and its relationship with the presence of the estrogen receptor.

Background: Breast cancer is an important cause of cancerrelated death in women. In this pathological condition, arginase plays a role by providing ornithine as a substrate for the biosynthesis of polyamines which are important in tumor progression. The aim of this work was to determine the arginase activity in the plasma and tumors of patients with breast cancer; also, we investigated the relationship between this activity and the presence of the estrogen receptor.

[Cost-effectiveness of the treatment of acute and chronic rhinosinusitis at the IMSS].

Introduction: Rhinosinusitis is one of the more common diseases encountered in outpatient visits to health care. The objective of this study was to determine the most cost-effective antibiotic treatment for patients with acute (RSA) and chronic rhinosinusitis (RSC) that is available at the Mexican Institute of Social Security (IMSS).

Methods: Cost-effectiveness analysis of RSA and RSC treatment from an institutional perspective.

[Age related spirometric changes in diabetic patients].

Background: Pulmonary volumes and expiratory flows progressively decline during aging, and some studies suggest that such decline is steeper among diabetic people.

Objective: To evaluate if diabetes mellitus (DM) accelerates the decline of pulmonary function occurring with aging.

Methods: A spirometric study was carried out in type-2 DM outpatients attending the family physician office, as well as in a control group of nondiabetic subjects.

[Inverse relationship between age and pulmonary function decline in the postoperative period of laparoscopic cholecystectomy].

Background: Abnormal lung mechanics with diminution of pulmonary volumes and airflows is an adverse effect occurring during the immediate postoperative period of the upper-abdomen surgery.

Objective: To evaluate the influence of age on the lung function decline occurring during the immediate postoperative period of laparascopic cholecystectomy.

Methods: Patients planned to be submitted to elective laparoscopic cholecystectomy were recruited from July to November 2000.

[Construction and validation of a clinical diagnostic-therapeutic guide for the hospitable management of patients with type 2 diabetes mellitus].

Objective: To develop and validate a diagnostic-therapeutic guideline (DTG) for the management of hospitalized diabetic patients, and apply it to a sample of medical files.

Material And Methods: The DTG was constructed and then validated by a consensus of internist physicians, afterwards it was applied to a sample of 97 randomly selected medical files of diabetic patients discharged from a internal medicine service. Hospitalization time, studies requested, average glycemia, glycemic prior to the discharge, time for to achieve glycemic control and mortality were compared at different percentages of the DTG's application.