975 results match your criteria: "Hospital General 'Dr. Manuel Gea Gonzalez'[Affiliation]"

Introduction: Several infectious diseases can present nail manifestations, which may be useful for diagnosis and prognosis, and only a few reports have been made regarding monkeypox (mpox). The objective of this study was to describe the clinical characteristics of nail alterations in patients living with HIV coinfected with mpox.

Methods: A prospective, cross-sectional study included patients living with HIV/AIDS, coinfected with mpox.

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Introduction: Chlorotrichosis, commonly known as "green hair," is an unusual trichological condition characterized by the accumulation of exogenous copper in individuals with light-colored hair and prior hair damage. It is primarily associated with inadequately maintained swimming pools.

Case Presentation: We report a case of chlorotrichosis in a 16-year-old female who presented with a sudden and pronounced change in hair color after initiating regular swimming.

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Purpose: The immunonutritional status of cancer patients has a profound impact on lifespan. Prognostic Nutritional Index (PNI) evaluates prognosis in operated patients with both neoplastic and non-neoplastic conditions. This study estimates the overall survival (OS) of Mexican patients operated on gastrointestinal stromal tumors (GIST) based on PNI.

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Detection of in and Ticks Collected from Cattle in Tamaulipas, Mexico.

Vector Borne Zoonotic Dis

November 2024

Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México.

Article Synopsis
  • - Rickettsia spp. are harmful bacteria that pose risks to public health and livestock production, leading to losses in meat and dairy quality, making their prevention and early treatment crucial.
  • - The study involved collecting hard ticks from Bos indicus cattle in Mexico, identifying them through morphological methods and genetic sequencing.
  • - Results showed the presence of Rickettsia amblyommatis in Amblyomma mixtum and Rhipicephalus microplus ticks, indicating the pathogen circulates in local livestock and calling for further research.
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Effect of the Complex Allele p.[Ile148Thr;Ile1023_Val1024del] in Cystic Fibrosis and Tracing of a Founder Effect in Mexican Families.

Life (Basel)

November 2024

Immunogenomics and Metabolic Diseases Laboratory, Instituto Nacional de Medicina Genómica, Secretaría de Salud, Tlalpan, Mexico City 14610, Mexico.

Cystic fibrosis (CF) is a rare autosomal recessive disease most commonly affecting the Caucasian population. CF diagnosis can be a challenge due to the large spectrum of pathogenic variants in the CFTR gene and the effects of complex alleles. Next-generation sequencing has improved our understanding of the contribution of these complex alleles to the wide spectrum of CF clinical symptoms and to the response to medications.

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Alzheimer's Disease: Understanding Motor Impairments.

Brain Sci

October 2024

Laboratorio de Patogénesis Molecular, Laboratorio 4, Edificio A4, Carrera Médico Cirujano, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla 54090, Mexico.

Alzheimer's disease (AD), the most prevalent neurodegenerative disorder and the leading cause of dementia worldwide, profoundly impacts health and quality of life. While cognitive impairments-such as memory loss, attention deficits, and disorientation-predominate in AD, motor symptoms, though common, remain underexplored. These motor symptoms, including gait disturbances, reduced cardiorespiratory fitness, muscle weakness, sarcopenia, and impaired balance, are often associated with advanced stages of AD and contribute to increased mortality.

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Article Synopsis
  • Acute pancreatitis (AP) is a rare but severe complication that can occur in patients with systemic lupus erythematosus (SLE), making diagnosis and treatment challenging.
  • A 20-year-old female with SLE experienced sudden severe abdominal pain, vomiting, and systemic inflammation, leading to lab tests confirming AP through elevated amylase and lipase levels.
  • The patient underwent aggressive treatment, including fluid resuscitation and intensive care monitoring, emphasizing the necessity for quick diagnosis and a coordinated care approach for SLE-related AP.
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The COVID-19 pandemic created an unprecedented situation for families worldwide, with its potential impact on child development remaining uncertain, particularly within Latin American communities. This study aimed to analyze child development in children from Costa Rica and Mexico who grew up during COVID-19 pandemic. A cross-sectional study was conducted using a convenience sample of 183 children; a historical control group of Costa Rican children (n = 171) was also included.

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Background: Acute kidney injury (AKI) is a frequent complication associated with severe COVID-19 and has been linked to increased mortality. While vaccination against SARS-CoV-2 has shown effectiveness in reducing severe COVID-19 outcomes, its impact on the development of AKI among hospitalized patients remains unclear.

Objective: To evaluate the effect of SARS-CoV-2 vaccination on the incidence and severity of AKI and 28-day mortality among hospitalized patients with severe COVID-19.

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BACKGROUND The relationship between different subgroups of type 2 diabetes (T2D) and the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver fibrosis has not been thoroughly studied. This study aims to determine the association between T2D subgroups and the risk of developing advanced liver fibrosis using the Fibrosis-4 (FIB-4) index, a non-invasive marker for assessing liver fibrosis risk. MATERIAL AND METHODS A total of 1205 patients with T2D were categorized into 4 distinct subgroups: severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), and mild age-related diabetes (MARD).

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Article Synopsis
  • - The study examined Clostridioides difficile infection (CDI) trends and outcomes in 16 healthcare facilities in Mexico from 2016 to 2022, focusing on patient demographics and clinical data.
  • - Out of 2,356 CDI cases identified, 90% were healthcare-associated, with common comorbidities including hypertension and diabetes; the 30-day mortality rate was 16%.
  • - The findings highlight the need for improved surveillance and standardized CDI classification in Mexico, noting stable rates but differences in incidence between public and private hospitals.
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Article Synopsis
  • The study analyzes the characteristics of oral reactions to injectable soft tissue fillers, focusing on 151 patients, predominantly females averaging 54.9 years old.
  • Most reactions occurred about 20.4 months after injection, often presenting as painless nodules in the lips, with silicone and polymethylmetacrylate being the most common fillers used.
  • Key findings showed differences in reaction patterns based on the type of filler and highlighted the importance for clinicians to recognize these potential reactions when assessing asymptomatic nodules in older female patients.
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Purpose: To develop Mexico's first methodologically rigorous clinical practice guideline for the management of adult overweight and obesity. The target audiences are interdisciplinary healthcare professionals across healthcare systems who are the first point of contact for patients with obesity in Mexico, patients, and health system decision makers.

Recent Findings: A review of recent international obesity clinical practice guidelines and an expert consensus process identified: i) common recommendations appropriate for implementation in Mexico and ii) knowledge gaps requiring the formulation of new recommendations.

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[Etiology of epilepsy in Mexico: results from the national multi-centre register].

Rev Neurol

October 2024

Instituto Nacional de Neurología y Neurocirugía Dr. Manuel Velasco Suárez, Ciudad de México, México.

Article Synopsis
  • Epilepsy significantly impacts many people in Mexico, with the study analyzing the main causes of the condition across a diverse patient sample from 89 hospitals between 2021-2022.
  • The analysis covered 6,653 patients, revealing that structural causes account for 46.1% of cases, while genetic causes were 12.9%, and a significant 40.9% of cases had unknown origins.
  • The findings highlight that structural and genetic causes are linked to specific seizure types, and most patients had comorbid conditions, with drug-resistant epilepsy being more prevalent in those with immune, infectious, and structural causes.
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Article Synopsis
  • Access to safe surgery is a human right, but significant disparities exist between high-income and low-to-middle-income countries in terms of surgical care.* -
  • The LASOS-Peds study is a 14-day international research project exploring the rates of complications after pediatric surgeries in Latin America, focusing on both elective and emergency cases.* -
  • Approved by an Institutional Review Board, the findings will be published in peer-reviewed journals and shared at international conferences, with the aim of improving pediatric surgical outcomes.*
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[Metabolic, clinical and body composition changes in Mexican adults undergoing bariatric surgery].

Nutr Hosp

December 2024

Departamento de Sistemas Biológicos. División de Ciencias Biológicas y de la Salud. Universidad Autónoma Metropolitana. Unidad Xochimilco.

Background: morbid obesity is a major public health problem that is increasing. Currently, there are a limited number of studies carried out in the Mexican population that describe the effects of bariatric surgery. Objective: to establish in obese people who undergoing weight loss surgery, the metabolic and body composition difference before and after bariatric surgery.

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The prevalence of mental health problems constitutes an open challenge for modern societies, particularly for low and middle-income countries with wide gaps in mental health support. With this in mind, five datasets were analyzed to track mental health trends in Mexico City during the pandemic's first year. This included 33,234 responses to an online mental health risk questionnaire, 349,202 emergency calls, and city epidemiological, mobility, and online trend data.

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Type 2 diabetes mellitus (T2DM) is a complex chronic disease characterized by decreased insulin secretion and the development of insulin resistance. Previous genome-wide association studies demonstrated that single-nucleotide polymorphisms (SNPs) present in genes coding for ion channels involved in insulin secretion increase the risk of developing this disease. We determined the association of 16 SNPs found in , , , and genes and the increased probability of developing T2DM.

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Background: Obesity is a significant risk factor for metabolic-associated steatotic liver disease (MASLD). The association between Helicobacter pylori (HP) infection and liver fibrosis has not been fully elucidated in patients with obesity and MASLD.

Methods: This observational retrospective study included clinical and biochemical parameters of patients with obesity undergoing bariatric surgery.

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Sleep debt-induced anxiety and addiction to substances of abuse: A narrative review.

Pharmacol Biochem Behav

December 2024

Grupo de Neurociencias: Laboratorio de Cannabinoides, Departamento de Fisiología, Facultad de Medicina, UNAM, Mexico. Electronic address:

Substance Use Disorder (SUD) has been conceptualized as an outcome of a dysregulated reward system. However, individuals with SUD suffer from anxiety with an intensity depending on the abstinence period length. This review discusses the role of anxiety as a major contributor to the initiation and perpetuation of SUD, and its dependence on an up-regulated defense-antireward system.

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Objective: We aimed to assess physical and psychosomatic manifestations of patients with long COVID and their association with a decreased patient's quality of life (QOL) or different times elapsed since the COVID-19 diagnosis.

Methods: This is a cross-sectional study. We retrospectively collected the clinical characteristics of adult patients who had tested positive for SARS-CoV-2 and had symptoms at least as early as 4 weeks after COVID-19 in México City between April 2020 and February 2021.

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Background: Parkinson's Disease (PD) is frequently associated with a spectrum of sleep-related disorders, including insomnia, Excessive Daytime Sleepiness (EDS), REM sleep Behaviour Disorder (RBD), Restless Legs Syndrome (RLS), and Sleep-related Breathing Disorders (SBDs). These disorders significantly impact PD patients' Quality of Life (QoL) and present unique diagnostic and therapeutic challenges.

Methods: This review has explored the intricate relationship between PD and sleep-related disorders, emphasizing their distinctive features and underlying neurobiological mechanisms.

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A 78-year-old man with a previous diagnosis of rheumatoid arthritis on prolonged treatment with corticosteroids presented with intense and progressive pain at the cervical level that prevented him from resting his head and walking, in addition to an ulcerative lesion covering 80% of the lingual area that was previously treated as oral candidiasis without improvement. On arrival, with no clinical or serological data of rheumatoid arthritis, immunosuppressive treatment was suspended, and a biopsy of the oral cavity was requested, confirming the diagnosis of lingual tuberculosis, an extremely rare disease, occurring in less than 1% of extrapulmonary cases. MRI of the cervical spine showed a crush fracture of the C6 and C7 bodies associated with spondylitis of probably infectious etiology that required surgical treatment, and histopathological studies confirmed Pott's disease.

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