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Superior Vena Cava Isolation With Cryoballoon in AF Ablation: Randomized CAVAC AF Trial.

Circ Arrhythm Electrophysiol

January 2025

Electrophysiology Unit (V.C.-U., M.S.-D., D.J.-S., C.A.-A., P.V.-M., A.L.-R., D.G.-R., D.S.-O., C.P.-T., E.G.-I., J.T.-R., I.F.-L.), Cardiology Service, Hospital Electrophysiology Unit Puerta de Hierro, Madrid, Spain.

Background: Superior vena cava (SVC) has been considered a specific trigger in atrial fibrillation development.

Methods: We investigated the efficacy and safety of combining cryoballoon pulmonary vein isolation (PVI) with SVC ablation compared with PVI alone in 100 patients with paroxysmal or non-long-standing persistent atrial fibrillation. Patients were randomly assigned to either the PVI+SVC ablation group or the PVI-only group.

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