Thoracic Hybrid Lesion: A Rare Case of Two Congenital Malformations.

Cystic cuboid adenomatous malformations (CCAM) are congenital pulmonary lesions, usually benign, that can progress into malignancy. Bronchopulmonary sequestration (BPS) is another type of malformation that consistsof an ectopic pulmonary tissue mass that doesn't participate in blood-gas exchanges, with vascularization provided by anomalous branches of the thoracic aorta. Hybrid lesions are lesions that have histological features of CCAM but with systemic vascularization, a pathognomonic sign of BPS.

Giant Tophaceous Gout: The Importance of Therapeutic Compliance.

Gout is a metabolic disease resulting from the deposition of monosodium urate crystals in joints, tissues, and organs. Nowadays, the treatment of hyperuricemia is easily accessible and widespread and mainly consists of xanthine oxidase inhibitors and uricosurics. In refractory and advanced cases of gout, amputation surgery may be required.

The Portuguese Severe Asthma Registry: Development, Features, and Data Sharing Policies.

The Portuguese Severe Asthma Registry ( RAG) was developed by an open collaborative network of asthma specialists. RAG collects data from adults and pediatric severe asthma patients that despite treatment optimization and adequate management of comorbidities require step 4/5 treatment according to GINA recommendations. In this paper, we describe the development and implementation of RAG, its features, and data sharing policies.

Prospective validation of a lymphocyte infiltration prognostic test in stage III colon cancer patients treated with adjuvant FOLFOX.

Background: The prognostic value of lymphocyte infiltration (LI) of colorectal carcinoma (CC) has been demonstrated by several groups. However, no validated test is currently available for clinical practice. We previously described an automated and reproducible method for testing LI and aimed to validate it for clinical use.