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Tenofovir-induced toxicity in renal proximal tubular epithelial cells: involvement of mitochondria.
AIDS
July 2017
aDepartment of Pharmacology, Faculty of Medicine, University of Valencia bFISABIO cDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Valencia dServicio de Nefrología, Hospital Universitario Doctor Peset eDepartment of Nephrology, Hospital Clinico-University of Valencia fCIBERehd, Valencia, Spain.
Objective: In-vivo studies suggest that mitochondria is involved in tenofovir (TFV)-induced renal toxicity, but the underlying mechanisms are still unclear. The aim of the present study was to assess the effects of TFV and its prodrug, TFV disoproxil fumarate, on mitochondrial function and cell survival/viability in a renal proximal tubular cell line.
Design And Methods: We evaluated parameters of cellular proliferation/survival (cell count, cell cycle, viability) and mitochondrial function (oxygen consumption, mitochondrial membrane potential, reactive oxygen species production) in NRK-52E cells.