4 results match your criteria: "Hospital Clínico Universitario INCLIVA Biomedical Research Institute[Affiliation]"
The utility of the Martius flap to treat an anovaginal fistula secondary to anal cancer-A video vignette.
Colorectal Dis
October 2024
Colorectal Surgery Unit, Department of General and Digestive Surgery, Hospital Clínico Universitario. INCLIVA Biomedical Research Institute, Valencia, Spain.
Haploidentical Stem Cell Transplantation With Posttransplant Cyclophosphamide Therapy vs Other Donor Transplantations in Adults With Hematologic Cancers: A Systematic Review and Meta-analysis.
JAMA Oncol
December 2019
Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Importance: Use of haploidentical (HAPLO) stem cell transplantation with posttransplant cyclophosphamide is rapidly increasing in adults with hematologic cancers. However, its specific role compared with other transplant strategies has yet to be identified.
Objective: To synthesize the existing evidence regarding outcomes of stem cell transplantations comparing HAPLO stem cell transplantation and posttransplant cyclophosphamide therapy with transplantations from matched related donors (MRDs), matched unrelated donors (MUDs), or mismatched unrelated donors (MMUDs).
Acute GVHD prophylaxis plus ATLG after myeloablative allogeneic haemopoietic peripheral blood stem-cell transplantation from HLA-identical siblings in patients with acute myeloid leukaemia in remission: final results of quality of life and long-term outcome analysis of a phase 3 randomised study.
Lancet Haematol
February 2019
University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Article Synopsis
- The study evaluated the long-term effects of using human anti-T-lymphocyte globulin (ATLG) with other medications in patients with acute leukaemia undergoing stem cell transplantation, finding that it reduced chronic graft-versus-host disease (cGVHD) without increasing relapse rates or infections.
- An extended follow-up aimed to assess long-term outcomes, including quality of life (QoL), which had not been extensively reported before.
- Patients were randomly assigned to receive either ATLG with standard GVHD prophylaxis or standard prophylaxis alone, with QoL assessed through specific questionnaires, and both studies' enrolment has been completed.
Bone marrow VEGFC expression is associated with multilineage dysplasia and several prognostic markers in adult acute myeloid leukemia, but not with survival.
Leuk Lymphoma
October 2018
a Department of Hematology and Medical Oncology , Hospital Clínico Universitario INCLIVA Biomedical Research Institute, Valencia , Spain.
Vascular endothelial growth factor C (VEGFC) stimulates leukemia cell proliferation and survival, and promotes angiogenesis. We studied VEGFC expression in bone marrow samples from 353 adult acute myeloid leukemia (AML) patients and its relationship with several clinical, cytogenetic, and molecular variables. We also studied the expression of 84 genes involved in VEGF signaling in 24 patients.
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