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An intermediate-purity factor VIII concentrate supports platelet adhesion under flow conditions.
Haemophilia
January 1997
Dep. Investigación y Desarrollo, Hoechst Ibérica S.A., Barcelona, Spain,Servicio de Hemoterapia y Hemostasia, Hospital ClÃÂnic i Provincial, Barcelona, Spain,Department of Pediatrics, University of Minnesota, Minnesota, USA.
Article Synopsis
- Von Willebrand factor (vWF) plays a crucial role in platelet adhesion to blood vessel walls, which is important for proper blood clotting, especially in treating von Willebrand disease (vWD) types 2 and 3.
- Factor VIII concentrates containing vWF, such as Haemate-P, have shown to effectively improve clotting metrics like shortening bleeding time and normalizing coagulation levels.
- Research revealed that vWF from these concentrates effectively binds to platelets and enhances their adhesion under blood flow conditions, suggesting it has significant implications for improving haemostasis.