8 results match your criteria: "Hospital Center and University of Coimbra[Affiliation]"

The purpose of this study was to characterize the clinical profile of patients with type 2 diabetes after COVID-19 vaccination. This prospective study has involved 100 adult diabetic patients followed in the primary health care. SARS-CoV-2 infection after COVID-19 vaccination was the outcome indicator.

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Introduction: Obstructive sleep apnea (OSA) is a disorder characterized by obstructive apneas, hypopneas, and/or arousals related to respiratory effort caused by repetitive collapse of the upper airway during sleep. Left untreated, or with poor adherence to treatment, is likely to lead to negative outcomes, especially cardiac or cerebrovascular diseases. Our objective was to investigate age as a potential factor that may interfere with adherence to treatment with automatic positive airway pressure (APAP).

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Aim: To investigate the prevalence of urinary tract infections in hospitalized patients with type 2 diabetes mellitus and identify corresponding risk factors.

Methods: We conducted a cross-sectional study on 7.347 patients with type 2 diabetes mellitus as the principal diagnosis, using hospitalization discharge summary data from January 1 to December 31, 2015.

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Dual treatment with shikonin and temozolomide reduces glioblastoma tumor growth, migration and glial-to-mesenchymal transition.

Cell Oncol (Dordr)

June 2017

Brain's Biomedicine Laboratory, Paulo Niemeyer State Brain Institute, Secretaria de Estado de Saúde do Rio de Janeiro, Rua do Resende 156, Rio de Janeiro, 20231-092, Rio de Janeiro, Brazil.

Article Synopsis
  • Glioblastomas (GBMs) are aggressive brain tumors that are resistant to treatment, with proteins involved in tumor invasion being a major concern.
  • This study investigates the effects of combining the drug shikonin (SHK) with temozolomide (TMZ) on the growth and movement of GBM cells.
  • The results show that the combination of SHK and TMZ decreases cell proliferation and migration, potentially by inhibiting certain proteins involved in tumor spread, suggesting this dual treatment may improve GBM therapy outcomes.
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Preserved face inversion effects in adults with autism spectrum disorder: an event-related potential study.

Neuroreport

May 2016

aVisual Neuroscience Laboratory, Institute for Biomedical Imaging and Life Science, Faculty of Medicine, University of Coimbra bNeurodevelopmental Unit and Autism of the Center of Child Development, Pediatric Hospital, Hospital Center and University of Coimbra cUniversity Clinic of Pediatrics, Faculty of Medicine, University of Coimbra dCenter for Research and Clinical Training, Pediatric Hospital, Hospital Center and University of Coimbra, Portugal.

Individuals with autism spectrum disorder (ASD) are impaired in face recognition and emotional expression identification. According to current models, there are at least three levels of face processing: first order (two eyes, above a nose, which is above a mouth), second order (the relative distance between features), and holistic (ability to recognize as faces images that lack distinctive facial features). Some studies have reported deficits in configural and holistic processing in individuals with ASD.

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We reported a case of a patient with suspected cauda equina syndrome secondary to sacral fracture, after sustaining a fall. The difficulty in early diagnosis of complex sacral fractures and the lack of clearly defined guidelines for treatment are highlighted. Thorough clinical examination is mandatory, in order to make an adequate initial assessment and follow symptoms progression and response to treatment.

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We report a case of a 66-year-old male patient presented to our pneumology ward with the diagnosis of neutropenic pneumonia. Therapy with granulocyte colony stimulating factors (G-CSF) and intravenous antibiotics was initiated as usual in this condition. The unexpected and acute onset of left-sided abdominal pain and sings of hypovolemic shock led us to a challenging diagnosis, rarely considered in non-traumatic patients.

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Tuberous sclerosis complex (TSC) is a genetic neurocutaneous disorder characterised by seizures, mental retardation and hamartoma formation in multiple organs, mainly in the brain, skin, kidney, liver, lung and heart. Renal manifestations occur in about 60-80% of all patients with TSC and their rate increases with age. We report the case of a 17-year-old boy with tuberous sclerosis who presented with abdominal pain associated with kidney failure.

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