362 results match your criteria: "Hospital CUF Descobertas[Affiliation]"

Background: The percentage of Portuguese psoriasis patients with psoriatic arthritis is unknown but musculoskeletal complaints related to PsA affect up to a third of patients. Dermatologists can identify early PsA as skin symptoms often precede joint symptoms in 80% of patients. Efficient and easy to perform screening tools are needed to help dermatologists effectively discriminate between Pso and PsA patients.

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Introduction: The field of pediatric spine surgery has encountered major changes and evolutions lately, with new treatment options available and the development of enabling technologies. This article aims to summarize the most relevant recent literature.

Materials And Methods: The five most relevant topics were selected and assigned to one or two authors who performed a comprehensive Pubmed database search for articles published in the last 4 years (2021-2024).

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Extreme myopic laser-assisted in situ keratomileusis (LASIK) poses challenges regarding future intraocular lens (IOL) power selection. A male patient in his 40s complained of progressive right eye (OD) diminished visual acuity. He had a history of myopic LASIK in both eyes (OU) 20 years before, and implantable collamer lens (ICL) implant in OU 8 years before.

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The twenty-first century has seen a fundamental shift in disease epidemiology with anthropogenic environmental change emerging as the likely dominant factor affecting the distribution and severity of current and future human disease. This is especially true of allergic diseases and asthma with their intimate relationship with the natural environment. Climate change-related variables including increased ambient temperature, heat waves, extreme weather events, air pollution, and rainfall distribution, all can affect asthma in children, but each of these variables also affects asthma via alterations in pollen production and release, outdoor allergen exposure or the microbiome.

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The European Society of Endocrinology (ESE) and the Union Européenne des Médecins Spécialistes (U.E.M.

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Article Synopsis
  • Drug-induced interstitial lung disease (DI-ILD) is a rising complication associated with certain anti-cancer therapies, particularly newer drugs like trastuzumab-deruxtecan, affecting their safe use.
  • Different drugs cause lung damage via various mechanisms—primarily cytotoxic and immune-mediated—but the exact pathways remain unclear.
  • Effective diagnosis and management of DI-ILD require teamwork among healthcare professionals, patient education for early detection, and further research to develop standard treatment protocols.
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Article Synopsis
  • The Measure Up 1, 2, and AD Up studies assessed the effectiveness and side effects of upadacitinib for treating atopic dermatitis in adolescents aged 12-17 over a period of 76 weeks, extending the research beyond the previously available 52-week data.
  • In a randomized clinical trial, participants received either upadacitinib (15 mg or 30 mg) or a placebo, with some receiving topical corticosteroids, allowing for varied analysis of its efficacy and safety.
  • Results showed that a significant percentage of adolescents achieved a major improvement in their condition, with 89.1%, 84.4%, and 87.8% meeting the criteria for reduction in severity, showcasing the medication
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Article Synopsis
  • * The study compared the effectiveness and safety of upadacitinib (UPA) and dupilumab (DUPI) in adolescents and adults with moderate-to-severe AD over 16 weeks, with UPA showing better results in reducing skin severity and itching.
  • * UPA was found to be significantly more effective than DUPI in achieving the treatment goals, with no new safety concerns reported during the study.
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Background: This study aims to compare clinical and functional results after distal biceps tendon repair in manual workers vs. non-manual workers.

Methods: This is a retrospective comparative study which refers to 57 cases with distal biceps tendon rupture, divided in manual workers (24 elbows) and non-manual workers (33), that were treated by a single incision with cortical button and interference screw fixation.

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Enhancing precision in hysteroscopic surgery: The role of intraoperative ultrasound.

Eur J Obstet Gynecol Reprod Biol

November 2024

Department of Obstetrics and Gynecology, Hospital CUF Descobertas, Lisbon, Portugal; Department of Obstetrics and Gynecology, NOVA Medical School/Faculdade de Ciências Médicas, NOVA University of Lisbon, Lisbon, Portugal.

Article Synopsis
  • * Adding intraoperative ultrasound (IOUS) during these procedures helps doctors see everything better, making sure they can safely do their work.
  • * Using IOUS can lower risks, like avoiding accidents during surgery and ensuring they fix things completely in complicated cases.
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Background: Aficamten is a cardiac myosin inhibitor that mitigates left ventricular outflow gradients in obstructive hypertrophic cardiomyopathy (oHCM). The clinical efficacy of aficamten across multiple outcome domains in oHCM has not been fully defined.

Objectives: This responder analysis from the SEQUOIA-HCM (Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM) trial characterizes the clinical impact of aficamten.

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Background: Geriatric Medicine (GM), concerned with well-being and health of older adults, can play a crucial role in the alignment of healthcare systems to the needs of the aged populations. However, countries have varying GM development backgrounds. The goal of PROGRAMMING- COST 21,122 Action is to propose the content of education and training activities in GM for healthcare professionals across various clinical settings, adapted to local context, needs, and assets.

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The femoroacetabular contact force and pressure are increased in the anterosuperior segment of the acetabulum in femoroacetabular impingement syndrome. We developed a special device for femoroacetabular contact force measurement in hip arthroscopy and present the surgical technique for measuring femoroacetabular contact force in the intact joint with a cam morphology and after cam resection, with the hip in different positions in a cadaver specimen. The device is introduced into the joint peripheral compartment.

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Article Synopsis
  • The study assesses the effectiveness of dorsal hemiepiphysiodesis of the first metatarsal as a less invasive alternative to traditional osteotomy for treating pes cavovarus (PCV) in pediatric patients.
  • A retrospective analysis of eight patients (14 feet) showed improvements in key foot angles (Meary's angle, Moreau Costa Bartani angle, and calcaneal pitch) post-surgery, with significant results indicating the method's positive impact.
  • Results suggest that this technique not only minimizes surgical risks but also allows for gradual correction as the patient grows, making it a viable option for managing PCV.
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Non-technical skills for neurosurgeons: An international survey.

Brain Spine

August 2024

Department of Neurosurgery, Fondazione I.R.C.C.S. Istituto Neurologico "C. Besta", Milano, Italy.

Article Synopsis
  • Neurosurgery requires not only technical skills but also non-technical skills (NTSs) to achieve mastery, highlighting the importance of both in surgical practice.
  • An international survey of 372 neurosurgeons indicates that qualities like attention to detail, humility, and self-awareness are vital for surgical precision and effective teamwork.
  • The study advocates for integrated training that includes simulations and mentorship to enhance NTSs, while also stressing the need for research aimed at improving educational methods, especially in regions with unequal access to neurosurgical care.
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Therapeutical Usefulness of PD-1/PD-L1 Inhibitors in Aggressive or Metastatic Pituitary Tumours.

Cancers (Basel)

August 2024

Faculdade de Medicina, Universidade Católica Portuguesa, 1649-023 Lisbon, Portugal.

Therapeutic options for pituitary neuroendocrine tumours (PitNETs) refractory to temozolomide are scarce. Immune checkpoint inhibitors (ICIs), particularly inhibitors of the programmed cell death-1 (PD-1) pathway and its ligand (PD-L1), have been experimentally used in aggressive or metastatic PitNETs. We aimed to study the therapeutic usefulness of anti-PD-1 drugs in patients with aggressive or metastatic PitNETs.

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This consensus document addresses the reduction of the environmental impact of inhalers in Portugal. It was prepared by the Portuguese Council for Health and the Environment and the societies representing the specialties that account for these drugs' largest volume of prescriptions, namely the Portuguese Society of Pulmonology, the Portuguese Society of Allergology and Clinical Immunology, the Portuguese Society of Pediatrics, the Portuguese Society of Internal Medicine, the Portuguese Association of General and Family Medicine and also a patient association, the Respira Association. The document acknowledges the significant impact of pressurized metered-dose inhalers on greenhouse gas emissions and highlights the need to transition to more sustainable alternatives.

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