2 results match your criteria: "Hospital CSV Arrixaca[Affiliation]"
Evidence for a lack of inotropic and chronotropic effects of glucagon and glucagon receptors in the human heart.
Cardiovasc Diabetol
May 2023
Department of Pharmacology, Faculty Medicine, Edificio LAIB, University of Murcia., 6ª Planta. Av. Buenavista, 32, El Palmar, 30120, Murcia, Spain.
Background: Glucagon is thought to increase heart rate and contractility by stimulating glucagon receptors and increasing 3',5'-cyclic adenosine monophosphate (cAMP) production in the myocardium. This has been confirmed in animal studies but not in the human heart. The cardiostimulatory effects of glucagon have been correlated with the degree of cardiac dysfunction, as well as with the enzymatic activity of phosphodiesterase (PDE), which hydrolyses cAMP.
View Article and Find Full Text PDFEffect of diazepam on adenosine 3',5'-cyclic monophosphate (cAMP) plasma levels in anesthetized patients.
Clin Ther
May 2004
Department of Anesthesia, Hospital CSV Arrixaca, Spain.
Background: It has been previously demonstrated that diazepam inhibits the cyclic nucleotide phosphodiesterase type 4 isozyme (PDE4). PDE enzymes mediate the hydrolysis of the nucleotide adenosine 3',5'-cyclic monophosphate (cAMP).
Objective: The aim of this study was to determine whether IV administration of diazepam affects cAMP plasma levels in anesthetized patients.