3 results match your criteria: "Hospital Amato Lusitano ULSCB[Affiliation]"

Introduction: Porto-sinusoidal vascular disease (PSVD) is an entity characterized by the absence of histologic liver cirrhosis and the detection of specific or non-specific histological findings, irrespective of the presence of portal hypertension (PHT). The pathogenesis remains poorly understood. Pulmonary arterial hypertension (PAH), independently of the presence of PHT, can be associated with an increase in central venous pressure, which can rarely lead to the development of downhill varices in the proximal esophagus.

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Transjugular Liver Biopsy: The Key to a Rare Etiology of Cholestatic Hepatitis after Bone Marrow Transplantation.

GE Port J Gastroenterol

December 2024

Serviço de Gastrenterologia, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal.

Article Synopsis
  • Hematopoietic stem cell transplantation (HSCT) can lead to serious complications like sinusoidal obstruction syndrome (SOS) and graft-versus-host disease (GVHD), which may show overlapping symptoms but rarely occur together.
  • A case of a 29-year-old male with acute myeloid leukemia experienced hyperbilirubinemia and signs of SOS early after HSCT, followed by the development of GVHD affecting his skin, intestines, and liver.
  • The complex nature of this case highlights the need for careful diagnostics, including liver hemodynamic studies and biopsies, to distinguish between SOS and GVHD, as both conditions can severely impact patient outcomes.
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