Relationship between triglyceride levels and different snoring states: a systematic review and meta-analysis.

Objective: High triglyceride (TG) levels are important risk factors for cardiovascular disease (CVD). Some recent studies have shown that snoring is also closely related to elevated TG levels. The specific pathogenesis of elevated TG levels in snoring patients is still unclear.

Association between biomass cooking fuels and prevalence of tuberculosis among households: a cross-sectional study from 2019 - 2021 in India.

Background: Indoor air pollution (IAP) is the major contributor (26%) to TB, in addition to other socioeconomic and environmental factors. It occurs in most developing countries like India, where people rely on the combustion of biomass-based solid fuels (low combustion efficiency and high pollution emissions) due to the prevailing socio-economic conditions. However, this cause-and-effect relationship between TB and IAP has not been studied much.

Endo 180 participates in collagen remodeling of the periodontal ligament during orthodontic tooth movement.

Background: Orthodontic tooth movement (OTM) relies on the remodeling of periodontal tissues, including the periodontal ligament (PDL) and alveolar bone. Collagen remodeling plays a crucial role during this process, allowing for the necessary changes in the PDL's structure and function. Endo180, an urokinase plasminogen activator receptor-associated protein, is a transmembrane receptor regulated collagen remodeling.

Elastic static power, its correlation with acute respiratory distress syndrome severity: A Bayesian post-hoc analysis of the Mechanical Power Day cross-sectional trial.

Objective: The relationship between different power equations and the severity of acute respiratory distress syndrome (ARDS) remains unclear. This study aimed to evaluate various power equations: total mechanical power, total elastic power (comprising elastic static and elastic dynamic power), and resistive power, in a cohort of mechanically ventilated patients with and without ARDS. Bayesian analysis was employed to refine estimates and quantify uncertainty by incorporating a priori distributions.

Association between phosphate and 30-day in-hospital mortality in paediatric ICU: a retrospective cohort study.

Background: Death rates in the intensive care unit (ICU) and paediatric ICU (PICU) are approximately 10.8% and 9.13%, respectively.

Knowledge, attitudes and practices among patients with impacted wisdom teeth towards teeth extraction in Jinan, Shandong Province, China: a cross-sectional study.

Objectives: This study aimed to assess the knowledge, attitudes and practices (KAP) of patients with impacted wisdom teeth towards tooth extraction, with the intention of identifying both gaps and opportunities for improved dental health education and practices.

Design: A cross-sectional study using a web-based questionnaire.

Setting: The study was conducted at the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, and Jinan Stomatological Hospital.

Efficacy of esketamine for chronic post-thoracotomy pain: protocol for a systematic review and meta-analysis.

Introduction: Chronic post-thoracotomy pain (CPTP) is a persistent and disabling condition affecting a significant proportion of patients after thoracotomy and posing a challenge for clinicians, despite advances in surgical and pain management strategies. Esketamine, the S-enantiomer of ketamine, has emerged as a promising therapeutic agent for various pain conditions, with evidence for its effectiveness in alleviating acute and chronic pain. This systematic review and meta-analysis will be conducted to assess the efficacy of esketamine in treating CPTP, and evaluate its effectiveness in reducing pain intensity, improving functional outcomes, and reducing opioid consumption, as well as its adverse effects.

Impaired coagulation parameters in early RA are restored by effective antirheumatic therapy: a prospective pilot study.

Objectives: To assess the effect of treatment on haemostatic parameters in patients with early rheumatoid arthritis (RA).

Methods: Patients with newly diagnosed RA started methotrexate and were randomised to additional conventional treatment, certolizumab pegol, abatacept or tocilizumab. Several biomarkers for haemostasis were analysed including parameters of the two global haemostatic assays-overall haemostatic potential (OHP) and endogenous thrombin potential (ETP), as well as single haemostatic factors-fibrinogen, prothrombin fragment 1+2 (F1+2), D-dimer, thrombin activatable fibrinolysis inhibitor (TAFI) and clot lysis time (CLT) in 24 patients at baseline, 12 and 24 weeks after the start of the treatment.

Tight Anastomosis of the Pancreatojejunostomy During Pancreatoduodenectomy May Cause Late Acute Pancreatitis.

Background/aim: To investigate risk factors of late acute remnant pancreatitis after pancreatoduodenectomy (PD), we propose the use of a suturing pitch calculated based on the diameter of the main pancreatic duct and the number of sutures used in the pancreatic duct-to-mucosa anastomosis. This study aimed to determine whether the suturing pitch can predict late acute pancreatitis following PD.

Patients And Methods: This study included 142 patients who underwent elective PD.

HOXA3 activates USP15 to suppress autophagy and promote M2-type macrophage polarization in renal cell carcinoma via facilitating the deubiquitination of SQSTM1.

The disease burden of renal cell carcinoma (RCC) has decreased in recent years with advances in treatment, but its pathogeny still remains elusive. We aim to study the role of HOXA3/USP15/SQSTM1 axis on autophagy and M2-type macrophage polarization in RCC. In this study, cell apoptosis and proliferation were assessed by flow cytometry and CCK-8.

Endovascular Treatment of Mirror Aneurysms in Subarachnoid Hemorrhage Patients: Single Stage or Multiple Stage?

Objective: The study evaluated the effectiveness and safety of single-stage versus multistage endovascular treatment in subarachnoid hemorrhage patients with Mirror Aneurysms.

Materials And Methods: Our research team performed a prospective study, focusing on the radiographic and clinical data of patients diagnosed with subarachnoid hemorrhage, specifically those who presented with Mirror Aneurysms upon admission to our institutions. According to the different endovascular treatment stages, these patients were grouped into the multistage cohort and the single-stage cohort.

A Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice.

Background: Pain is a prevalent comorbidity in numerous clinical conditions and causes suffering; however, the mechanism of pain is intricate, and the neural circuitry underlying pain in the brain remains incompletely elucidated. More research into the perception and modulation of pain within the central nervous system is essential. The nucleus accumbens (NAc) plays a pivotal role in the regulation of animal behavior, and extensive research has unequivocally demonstrated its significant involvement in the occurrence and development of pain.

Ascorbate-loaded MgFe layered double hydroxide for osteomyelitis treatment.

Bacterial infections evoke considerable apprehension in orthopedics. Traditional antibiotic treatments exhibit cytotoxic effects and foster bacterial resistance, thereby presenting an ongoing and formidable obstacle in the realm of therapeutic interventions. Achieving bacterial eradication and osteogenesis are critical requirements for bone infection treatment.

Hip-lumbar mobility loss affects quality of life in patients undergoing both lumbar fusion and total hip arthroplasty.

Aims: Overall sagittal flexion is restricted in patients who have undergone both lumbar fusion and total hip arthroplasty (THA). However, it is not evident to what extent this movement is restricted in these patients and how this influences quality of life (QoL). The purpose of this study was to determine the extent to which hip-lumbar mobility is decreased in these patients, and how this affects their QoL score.

Exploring midwives' perceptions of the multisensory birthing room work environment: A qualitative analysis.

Background: Multisensory birthing rooms are specially designed and integrate elements such as sound, light, and visual stimuli to create an immersive atmosphere.

Aim: To investigate how implementing multisensory birthing rooms affect midwives' perceptions of their working environment.

Methods: The data material consisted of 16 semi-structured interviews.

Exposure to Bisphenol A jeopardizes decidualization and consequently triggers preeclampsia by up-regulating CYP1B1.

Preeclampsia (PE) is a pregnancy-related disease that poses a significant threat to the health of both the mother and the fetus. Previous studies have primarily focused on the role of the placenta in PE pathogenesis; however, normal decidualization is crucial for the subsequent development of the placenta and pregnancy. Bisphenol A (BPA) is an environmental endocrine disruptor commonly used in the synthesis of polycarbonate and epoxy resins.

β-Catenin mediated TAM phenotype promotes pancreatic cancer metastasis via the OSM/STAT3/LOXL2 axis.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by its aggressive nature and dismal prognosis, largely attributed to its unique tumor microenvironment. However, the molecular mechanisms by which tumor-associated macrophages (TAMs) promote PDAC progression, particularly the role of β-catenin signaling in regulating TAM phenotype and function, remain incompletely understood. Initially, we performed comprehensive analyses of RNA-seq and single-cell RNA-seq (scRNA-seq) datasets to investigate OSM and LOXL2 expression patterns in PDAC.

HSPA5-mediated glioma hypoxia tolerance promotes M2 macrophage polarization under hypoxic microenvironment.

Background: The tumor microenvironment (TME), with hallmark features of hypoxia and immunosuppression, plays a crucial role in the progression of various solid tumors. However, the intricate interplay between tumor hypoxia and the formation of tumor immune microenvironment in glioma remains incompletely understood.

Methods: In the present study, we initially identified genes associated with tumor hypoxia and the immune microenvironment through GSEA and IMMPORT database analysis.

4D bioprinting of transformable living constructs with sustained local growth factor presentation for advanced tissue engineering applications.

Traditional tissue engineering strategies focus on geometrically static tissue scaffolds, lacking the dynamic capability found in native tissues. The emerging field of 4D bioprinting offers a promising method to address this challenge. However, the requirement for consistent exogenous supplementation of growth factors (GFs) during tissue maturation poses a significant obstacle for in vivo application of 4D bioprinted constructs.

Management of operating theatre ambient temperature for major burn patients in a state-wide adult burns centre.

Introduction: The aim of this study was to investigate the efficacy of limiting increases in theatre ambient temperature to 27°C to prevent intraoperative patient hypothermia.

Methods: This single-centre, comparative cohort clinical study investigated the management of theatre ambient temperatures involving patients with ≥ 20 % TBSA burn injuries at Victorian Adult Burns Service (Melbourne, Australia). Data from the intervention group (August 2021 - February 2023, theatre ambient temperature increase limited to 27°C) was compared with a historical cohort (August 2019 - August 2021).

Exploring micro(nano)plastics toxicity from an environmental management perspective: Zebrafish as a vital bridge for assessing potential human health risks.

The pollution stemming from the unwarranted utilization and inadequate disposal of plastic products is undergoing rapid escalation. The problem of micro(nano)plastics (MNPs) pollution has recently garnered significant attention, and the issue of human exposure to MNPs cannot be disregarded. However, the present state of research concerning human exposure to MNPs remains in its early stages.

Network pharmacology, molecular docking, and experimental verification to reveal the mechanism of colquhounia root tablet in the treatment of diabetic nephropathy.

Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus. Colquhounia Root Tablet (CRT), one of the Tripterygium wilfordii Hook F. (TwHF)-based therapeutics, has exhibited various functions in DN.

Mucosal vaccination against SARS-CoV-2 using recombinant influenza viruses delivering self-assembling nanoparticles.

Recombinant influenza viruses are promising vectors that can bolster antibody and resident lymphocyte responses within mucosal sites. This study evaluates recombinant influenza viruses with SARS-CoV-2 RBD genes in eliciting mucosal and systemic responses. Using reverse genetics, we generated replication-competent recombinant influenza viruses carrying heterologous RBD genes in monomeric, trimeric, or ferritin-based nanoparticle forms.