1,077 results match your criteria: "Hoseo University[Affiliation]"

Natural compounds for Alzheimer's prevention and treatment: Integrating SELFormer-based computational screening with experimental validation.

Comput Biol Med

December 2024

Department of Bioconvergence, Hoseo University, Asan, South Korea; Dept. of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, Asan, South Korea. Electronic address:

Article Synopsis
  • This study developed a computational pipeline using SELFormer, a transformer-based model, to identify natural compounds that may help in treating Alzheimer's disease by focusing on seven specific genes related to the condition.
  • Researchers employed various analytical methods, including clustering, QSAR, and UMAP, followed by molecular docking and in vitro tests to evaluate the efficacy of selected compounds in biological models.
  • Findings revealed five clusters of natural compounds, with 17 showing strong activity; specific compounds like cowanin and β-caryophyllene exhibited promising results, enhancing cell viability and reducing harmful markers, while also linking these compounds to dietary sources such as mangosteen and celery.
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Research Trends in the Development of Block Copolymer-Based Biosensing Platforms.

Biosensors (Basel)

November 2024

Department of Chemistry and Biochemistry, Concordia University, Montreal, QC H4B 1R6, Canada.

Biosensing technology, which aims to measure and control the signals of biological substances, has recently been developed rapidly due to increasing concerns about health and the environment. Top-down technologies have been used mainly with a focus on reducing the size of biomaterials to the nano-level. However, bottom-up technologies such as self-assembly can provide more opportunities to molecular-level arrangements such as directionality and the shape of biomaterials.

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Service Design and Evaluation of OpenNotes for Craniofacial Deformity Management in Patients and their Caregivers.

Healthc Inform Res

October 2024

Department of Plastic Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Objectives: This study aimed to assess the feasibility of implementing OpenNotes in Korea. It involved developing and evaluating the Open-CHA service, which provides clinical summary information to patients diagnosed with craniofacial deformities and their caregivers following outpatient visits.

Methods: The study included 109 patients diagnosed with craniofacial deformities, along with their caregivers.

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Dietary quality, perceived health, and psychological status as key risk factors for newly developed metabolic dysfunction-associated steatotic liver disease in a longitudinal study.

Nutrition

February 2025

Korea Department of Bioconvergence, Hoseo University, Asan, South Korea; Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, Asan, South Korea. Electronic address:

Objectives: This study investigated biomarkers in individuals with newly developed metabolic dysfunction-associated steatotic liver disease (ND-MASLD) and examined the interplay between genetic predisposition and environmental factors using a machine learning approach in a large longitudinal study.

Methods: Participants were classified into four groups based on metabolic dysfunction-associated steatotic liver disease (MASLD) status between the first and second measurements with an approximate 5-y gap. A model was developed to identify early-stage biomarkers of ND-MASLD (n = 1603).

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Article Synopsis
  • Traditional inhalation toxicity tests for respiratory chemicals often rely on animal testing, leading to ethical concerns and limitations due to anatomical differences and complex processes.
  • This study developed an alternative method using a co-culture system with differentiated epithelial cells and fibroblasts to mimic the human respiratory wound-healing process.
  • The new multi-analysis model effectively measures toxicological responses and functional assessments, showing significant changes such as cytotoxicity and reduced cilia motility, indicating its potential for more accurate predictions of pulmonary toxicity.
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Relationship between HECTD4 gene variants, obesity, and coffee consumption.

Eur J Clin Nutr

November 2024

Department of Medical Sciences, Graduate School, Soonchunhyang University, Asan, Chungnam, Republic of Korea.

Background: In genome-wide association studies, the HECT domain E3 ubiquitin-protein ligase 4 (HECTD4) gene was suggested to be associated with obesity-related traits and coffee consumption. However, the association of genetic variants between coffee consumption and obesity has not been tested in Koreans. Therefore, we investigated whether HECTD4 gene variants act as effect modifiers on the relationship between obesity and coffee.

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Background/objectives: Fructus (SCF) is a traditional medicinal herb containing lignans that improves glucose metabolism by mitigating insulin resistance. We aimed to investigate the therapeutic potential and action mechanism of SCF for Alzheimer's disease (AD) using a network pharmacology analysis, followed by experimental validation in an AD rat model.

Methods: The biological activities of SCF's bioactive compounds were assessed through a network pharmacology analysis.

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Special Issue: "Gut Microbiota and Nutrition in Human Health".

Int J Mol Sci

October 2024

Department of Bioconvergence, Hoseo University, Asan 31499, Republic of Korea.

The microbiome is a singular term for a vast array of life forms that live symbiotically within the bodies of human and animal hosts, forming commensal, parasitic, or mutualistic relationships [...

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Article Synopsis
  • The study investigates the rise in limitations of activities of daily living (ADLs) among people with disabilities in Korea, highlighting the need for a comprehensive approach due to the aging population.
  • Data from 346 individuals were analyzed over 12 years, revealing a 16.5% increase in ADL limitations, particularly among those with mental disorders, seniors over 65, and individuals with depression.
  • The research identifies severe disability and low education level as consistent predictors of ADL limitations, underscoring the importance of understanding trends and factors to improve management strategies.
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Pinus koraiensis essential oil enhances glucose uptake and proliferation in SH-SY5Y neuroblastoma cells.

Sci Rep

November 2024

Department of Biotechnology, College of Life and Health Sciences, Hoseo University, Baebang, Asan, 31499, South Korea.

Aromatherapy using essential oils (EOs) is well known for its beneficial effects on mental health and neuroprotection. However, the significant molecular mechanisms have not yet been identified. Recent studies have identified a decrease in glucose uptake as a common feature across various neurodegenerative diseases (NDDs), leading to mitochondrial dysfunction and excessive autophagy.

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  • The study focuses on enhancing CT image reconstruction methods, specifically critiquing the limitations of sinogram upscaling networks which struggle with aliasing artifacts and low-contrast structures.
  • It introduces a new approach using a view-by-view back-projection tensor-domain network that directly addresses these aliasing issues, utilizing multi-planal anti-aliasing modules for improved artifact removal.
  • The proposed tensor-domain method significantly outperformed traditional sinogram-based techniques in both numerical and clinical tests, demonstrating better recovery of image details and clarity through its advanced processing capabilities.
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Lead halide perovskite single crystals (LHPSC) are promising for room-temperature γ-ray spectroscopy in radiation detection. While MA(CHNH)-based LHPSCs are the most straightforward and cost-effective to synthesize from solution, their performance in γ-ray spectroscopy is hindered by significant noise and ion migration at high bias, which degrades their energy resolution (ER). The work introduced an n-type/intrinsic/n-type photodiode incorporating passivation layers of MA-based LHPSCs, grown through solution-process epitaxial growth.

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SSIM-Based Autoencoder Modeling to Defeat Adversarial Patch Attacks.

Sensors (Basel)

October 2024

Department of Information Security, Hoseo University, Asan 31499, Republic of Korea.

Object detection systems are used in various fields such as autonomous vehicles and facial recognition. In particular, object detection using deep learning networks enables real-time processing in low-performance edge devices and can maintain high detection rates. However, edge devices that operate far from administrators are vulnerable to various physical attacks by malicious adversaries.

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Background/objectives: This study investigated the relationship between single nucleotide polymorphisms (SNPs) and gastric cancer (GC) risk, while also examining the interaction of genetic factors with lifestyle variables including the nutrient and bioactive compound intake in Korean adults of a large hospital-based cohort.

Methods: We conducted a genome-wide association study (GWAS) comparing GC patients ( = 312) with healthy controls without cancers ( = 47,994) to identify relevant genetic variants. Generalized multifactor dimensionality reduction (GMDR) was employed to detect SNP interactions between diets and lifestyles.

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Impact of Mobile Health Literacy, Stroke-Related Health Knowledge, Health Beliefs, and Self-Efficacy on the Self-Care Behavior of Patients with Stroke.

Healthcare (Basel)

September 2024

Department of Nursing Science, Research Institute of Nursing Science, School of Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.

The recent substantial increase in the incidence of stroke cases has resulted in high medical expenses. Stroke necessitates ongoing care, emphasizing the importance of consistent self-management. The occurrence of stroke impacts healthcare costs and has far-reaching effects on social services, encompassing disability, unemployment, and other related concerns beyond individuals and families.

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Article Synopsis
  • The study investigates the relationship between carbonated sugar-sweetened beverage (CSSB) intake and the risk of metabolic syndrome (MetS), considering both genetic factors and dietary habits.
  • Analyzing data from 57,940 participants, it categorizes them into low-CSSB and high-CSSB groups, revealing that high consumers also have poorer dietary patterns and higher consumption of unhealthy foods.
  • The research highlights that genetic predisposition, assessed through specific genetic markers, interacts with diet type, indicating that tailored dietary recommendations may help reduce MetS risk, especially for those with higher CSSB intake and Western-style diets.
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Dermal toxicity studies of 1,2-benzisothiazolin-3-one (CAS number: 2634-33-5) in Sprague-Dawley rats.

Food Chem Toxicol

November 2024

Lab of Toxicology, Department of Health Sciences, The Graduate School of Dong-A University, 37, Nakdong-daero 550 beon-gil, Saha-gu, Busan, 49315, Republic of Korea. Electronic address:

Biocides are used as preservatives in various household products, and 1,2-benzisothiazolin-3-one (BIT) is one of the popular chemicals. Therefore, BIT is highly likely to be exposed to human skin, necessitating dermal toxicity evaluation. In this study, we aimed to investigate dermal toxicity, eyes and skin irritation, and skin sensitization of BIT.

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This paper presents a numerical investigation into the fire endurance of carbon fiber reinforced polymer (CFRP)-strengthened columns, shielded with fire-resistant materials, in piloti-type reinforced concrete buildings. The strengthened column, equipped with a fire protection system, underwent exposure to the ASTM E119 standard time-temperature curve for a duration of 4 h. To comprehensively evaluate the thermal and structural performance of the strengthened column at elevated temperatures and substantiate the effectiveness of the fire protection system, a fully coupled thermal-stress analysis was conducted.

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3D Bioprinting of Pig Macrophages and Human Cells Discovered the P2Y14 Receptor as a Mediator of Xenogenic Immune Responses.

Immunol Invest

October 2024

Department of Biotechnology, College of Life and Health Sciences, Hoseo University, Asan, Republic of Korea.

Background: The survival rate of pig lung xenotransplantation (PLXTx) recipients is severely limited by intense xenogenic immune responses, necessitating further insights into xenogeneic immunity and the development of models to study the PLXTx immune response.

Methods: We identified regulators of PLXTx immune response Using Gene ontology analysis. We assessed the metabolic changes and protein levels in 3D4/31 pig alveolar macrophages (PAMs) through flow cytometry and immunoblotting.

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Article Synopsis
  • This study assesses how well automated machine learning techniques (AutoGluon and autofeat) diagnose acute appendicitis (AA) using both clinical and CT data, comparing their performance against traditional methods like logistic regression and the Adult Appendicitis Score.
  • A total of 303 adult patients with unclear CT results were analyzed, with the AutoGluon-clinical-CT model achieving the highest diagnostic accuracy (AUROC 0.886), outperforming other models, including ridge regression with clinical data alone.
  • The study also identified a significant new feature related to diagnosing AA, combining time since pain onset and rebound tenderness, highlighting potential improvements in diagnostic accuracy for uncertain cases.
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With the development of artificial intelligence (AI), technologies based on machines and deep learning are being used in many academic fields. In toxicopathology, research is actively underway to analyze whole slide image (WSI)-level images using AI deep-learning models. However, few studies have been conducted on models for diagnosing complex lesions comprising multiple lesions.

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Metabolic dysfunction-associated steatotic liver disorder (MASLD) is increasingly prevalent globally, highlighting the need for preventive strategies and early interventions. This comprehensive review explores the potential of health functional foods (HFFs) to maintain healthy liver function and prevent MASLD through an integrative analysis of network pharmacology, gut microbiota, and multi-omics approaches. We first examined the biomarkers associated with MASLD, emphasizing the complex interplay of genetic, environmental, and lifestyle factors.

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Alzheimer's disease (AD) is characterized by impaired insulin/insulin-like growth factor-1 signaling in the hippocampus. Zeaxanthin and lutein, known for their antioxidant and anti-inflammatory properties, have been reported to protect against brain damage and cognitive decline. However, their mechanisms related to insulin signaling in AD remain unclear.

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Crystal Structures and Piezoelectric Properties of Quenched and Slowly-Cooled BiFeO-BaTiO Ceramics.

Materials (Basel)

September 2024

Department of Materials Science & Engineering, Hoseo University, Asan 31499, Republic of Korea.

The BiFeO-BaTiO (BF-BT) ceramics were here prepared through the solid-state reaction of BiO, FeO and nano-sized BT powders. The crystal structures and piezoelectric properties were investigated in both quenched (AQ) and slowly cooled (SC) 0.7BF-0.

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