12 results match your criteria: "Horus University in Egypt (HUE)[Affiliation]"

This study evaluated the antioxidant and antibacterial properties of methanolic extracts derived from oilseed cakes of (lettuce), (black seed), (rocket), and (linseed). Lettuce methanolic extract showed the highest potential, so it was selected for further investigation. High-performance liquid chromatography (HPLC-DAD) analysis and bioassay-guided fractionation of lettuce seed cake extract led to the isolation of five compounds: 1,3-propanediol-2-amino-1-(3',4'-methylenedioxyphenyl) (), luteolin (), luteolin-7-O--D-glucoside (), apigenin-7-O--D-glucoside (), and -sitosterol 3-O--D-glucoside ().

View Article and Find Full Text PDF

Type 1 diabetes stem-cell-based treatment approach is among the leading therapeutic strategies for treating cardiac damage owing to the stem cells' regeneration capabilities. Mesenchymal stem cells derived from adipose tissue (AD-MSCs) have shown great potential in treating diabetic cardiomyopathy (DCM). Herein, we explored the antioxidant-supporting role of N, N'-diphenyl-1,4-phenylenediamine (DPPD) in enhancing the MSCs' therapeutic role in alleviating DCM complications in heart tissues of type 1 diabetic rats.

View Article and Find Full Text PDF

The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats.

Tissue Cell

April 2024

Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; Department of Anatomy and Neurobiology, College of Medicine and Health Sciences, National University of Science and Technology, Sohar, Oman. Electronic address:

Parkinson's disease (PD) is one of the most common neurodegenerative conditions. Alpha-synuclein deposition, Lewy bodies (LBs) formation, disruption of the autophagic machinery, apoptosis of substantia nigra dopaminergic neurons, oxidative stress, and neuroinflammation are all pathologic hallmarks of PD. The leaves of the stinging Nettle (Urtica dioica L.

View Article and Find Full Text PDF

DPP-4i versus SGLT2i as modulators of PHD3/HIF-2α pathway in the diabetic kidney.

Biomed Pharmacother

November 2023

Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, 35516, Egypt; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, 35516, Egypt; Department of Medical Biochemistry, Horus University in Egypt (HUE), New Damietta, Damietta, Egypt.

Rationale: Renal hypoxia is one of the currently highlighted pathophysiologic mechanisms of diabetic nephropathy (DN). Both hypoxia-inducible factor-1α (HIF-1α) and HIF-2α are major regulators of renal adaptive responses to hypoxia.

Objectives: This study aims to compare the effects of vildagliptin (a dipeptidyl peptidase-IV inhibitor, DPP-4i) and empagliflozin (a sodium-glucose cotransporter 2 inhibitor, SGLT2i) on the differential expression of renal HIF-1α/2α.

View Article and Find Full Text PDF

Mesenchymal stem cells (MSCs) are considered to be a promising therapeutic protocol for diabetes mellitus (DM) management. The latter is attributed to their differentiation potentiality to pancreatic β-cells, angiogenesis, and immune-modulatory capabilities by releasing various paracrine factors. Interestingly, antioxidant co-administration increased the MSCs' hypoglycemic and regenerative activities.

View Article and Find Full Text PDF

The proposed hybrid deep learning intrusion prediction IoT (HDLIP-IoT) framework.

PLoS One

August 2022

Computer Engineering and Systems Department, Faculty of Engineering, Mansoura University, Mansoura, Dakahlia, Egypt.

Throughout the past few years, the Internet of Things (IoT) has grown in popularity because of its ease of use and flexibility. Cyber criminals are interested in IoT because it offers a variety of benefits for users, but it still poses many types of threats. The most common form of attack against IoT is Distributed Denial of Service (DDoS).

View Article and Find Full Text PDF

Background: The new therapeutic strategy of managing cardiac diseases is based on cell therapy; it highly suggests the use of multipotent mesenchymal stem/stromal cells (MSCs). MSCs widely used in researches are known to be isolated from bone marrow. However, this research seeks to use a human umbilical cord (HUC) as an alternative source of MSCs.

View Article and Find Full Text PDF

Background: Successfully overcoming obstacles due to anticancer drugs' toxicity and achieving effective treatment using unique nanotechnology is challenging. The complex nature of breast tumors is mainly due to chemoresistance. Successful docetaxel (DTX) delivery by nanoparticles (NPs) through inhibition of multidrug resistance (MDR) can be a bridge to enhance intracellular dose and achieve higher cytotoxicity for cancer cells.

View Article and Find Full Text PDF

Interleukin-17 (IL-17) is a critical cytokine involved in inflammation-associated cancers. Single nucleotide polymorphisms (SNPs) might promote carcinogenesis. In this current meta-analysis, we investigated the association of IL-17A and IL-17F gene polymorphisms with gastric cancer (GC) risk.

View Article and Find Full Text PDF

Background: Previous reports demonstrated the role of TP53 gene polymorphisms with CRC risk among several ethnic populations. The purpose of this study is to assess the association of the TP53 Arg72Pro and Pro47Ser variants with CRC risk among Egyptian patients.

Subjects And Methods: This work was conducted on 120 unrelated CRC Egyptian patients who were compared to 140 healthy controls.

View Article and Find Full Text PDF

A simple rapid and accurate micellar high performance liquid chromatographic method was improved and validated for the analysis of mixture containing gatifloxacin sesquihydrate (GTF) and prednisolone acetate (PRED) in their synthetic mixture and their combined preparation. The separation was achieved using a C18 column, micellar mobile phase consisted of 0.2 M sodium dodecyl sulfate, 12.

View Article and Find Full Text PDF

Background: Genetic polymorphisms of IL-23 R (rs7517847) and LEP (rs7799039) have been stated to be associated with various types of human cancers. The purpose of this work is to test the association of these genetic polymorphisms with hepatocellular carcinoma (HCC) among Egyptian patients.

Subjects And Methods: This study involved 150 unrelated Egyptian HCC patients in addition to 100 healthy controls from the same locality.

View Article and Find Full Text PDF