5,423 results match your criteria: "Hopitaux universitaires de Strasbourg[Affiliation]"

Article Synopsis
  • Rheumatoid arthritis (RA) is an autoimmune disease causing chronic inflammation in joints and other organs, leading to potential joint damage and increased health risks if not properly managed.
  • Interleukin-6 (IL-6) is a key cytokine involved in RA, making it a significant target for treatment; therapies like tocilizumab can block IL-6 receptors and help reduce inflammation.
  • Personalizing RA treatment based on individual patient profiles and addressing related health issues can improve outcomes, with a focus on a 'treat-to-profile' strategy that considers the patient's overall health.
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Narrative review of tissue-mimicking materials for MRI phantoms: Composition, fabrication, and relaxation properties.

Radiography (Lond)

October 2024

University of Strasbourg, CNRS, Inserm, ICube UMR 7357, Strasbourg, France; Pôle d'imagerie Médicale, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; Faculté de Médecine, Maïeutique et Sciences de la Santé, Université de Strasbourg, Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg, Faculté de Médecine, Université de Strasbourg, Strasbourg, France. Electronic address:

Introduction: Tissue-mimicking materials (TMMs) are now essential reference objects for quality control, development and training in all medical imaging modalities. This review aims to provide a comprehensive synthesis of materials used in the fabrication of TMMs for MRI phantoms, focusing on their composition, fabrication methods, and relaxation properties (T1 and T2).

Methods: A systematic review was conducted, covering articles published between 1980 and 2023.

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Background: Despite scarce data, invasive mechanical ventilation (MV) is widely suggested as first-line ventilatory support in cardiogenic shock (CS) patients. We assessed the real-life use of different ventilation strategies in CS and their influence on short and mid-term prognosis.

Methods: FRENSHOCK was a prospective registry including 772 CS patients from 49 centers in France.

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[How to read new antimicrobial susceptibility testing results?].

Rev Prat

October 2024

AP-HP, hôpital Henri-Mondor, Unité transversale de traitement des infections, Créteil, France.

HOW TO READ NEW ANTIMICROBIAL SUSCEPTIBILITY TESTING RESULTS? Antimicrobial susceptibility testing (AST) results (formerly 'susceptible', 'intermediate' and 'resistant') are now expressed with the new susceptibility categories 'susceptible, standard dosing regimen', 'susceptible, increased exposure' and 'resistant'. These new categories introduce a paradigm shift in the way clinicians have to interpret AST results: uncertainties (previously embedded in the 'intermediate' category) now have to be dealt with exclusively by the laboratory, independently from the clinical categorization itself, and both 'susceptible, standard dosing regimen' and 'susceptible, increased exposure' categories are associated with a high likelihood of therapeutic success if appropriate dosing regimen is used. To help clinicians, a dosing table (fitting dosing regimens usually recommended in France, and consistent with clinical breakpoints) is now available as an appendix to the CA-SFM document (Comité de l'antibiogramme de la Société française de microbiologie), and can also be downloaded from the SPILF website (Société de pathologie infectieuse de langue française).

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[Pregnancy after breast cancer: Supporting the "transgression"].

Gynecol Obstet Fertil Senol

December 2024

Service de gynécologie obstétrique et médecine de la reproduction, hôpital Tenon, AP-HP, Sorbonne université, Paris, France; Réseau Cancer associé à la Grossesse, CALG, Paris, France.

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High-fidelity anatomical phantoms for MRI practical training.

Phys Med

November 2024

University of Strasbourg, CNRS, Inserm, ICube UMR 7357, Strasbourg, France; Pôle d'imagerie médicale, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; Faculté de Médecine, Maïeutique et Sciences de la Santé, Université de Strasbourg, Strasbourg, France. Electronic address:

Introduction: Practical MRI training is essential for bridging the gap between complex theoretical knowledge and clinical applications. Traditional phantoms used in MRI, such as ACR phantoms, are valuable for illustrating system characterization methods but often lack the anatomical complexity required for realistic training. This study presents the development of high-fidelity anatomical phantoms designed specifically for practical MRI training.

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A Persistent Abdominal Pain With High Blood Pressure.

Am J Med

October 2024

Emergency Department, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; Faculté de médecine, Université de Strasbourg, Strasbourg, France. Electronic address:

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Article Synopsis
  • The study examines the effectiveness of endoscopic injections versus ureteral reimplantation for treating vesicoureteral reflux (VUR) in children with grades III, IV, and V, using data from 400 patients over a follow-up period of at least 5 years.
  • In Group A (endoscopic injections), patients experienced shorter surgery times, less need for pain relief, shorter hospital stays, and lower costs, but faced higher rates of post-procedure complications and redo surgeries compared to Group B (surgery).
  • Overall, while endoscopic treatment is quicker and cheaper with certain advantages, the surgical approach has a lower recurrence rate, suggesting potential long-term benefits for children.
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Heart failure (HF) with preserved ejection fraction (pEF) has lacked effective treatments for reducing mortality. However, previous studies have found an association between statin use and decreased mortality in patients with HFpEF. The aim of this study was to analyse whether statin therapy is associated with a reduction in mortality in these patients and whether the effect differs according to the presence or absence of ischaemic heart disease (IHD).

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Objectives: Neoehrlichia mikurensis (NM) is an emerging intracellular bacterium member of the Anaplasmatacecae family. So far, only four cases have been described in France, all of them retrospectively.

Methods: This study describes two new cases of NM discovered following implementation of a biplex PCR targeting both Anaplasma and NM.

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Article Synopsis
  • * This study analyzed cases of C bantiana infections in France and its territories, involving patients who were diagnosed through a comprehensive surveillance program, focusing on survival rates and the presence of central nervous system (CNS) involvement.
  • * Out of 23 patients identified from 2002 to 2022, 65% had CNS involvement, with a notable increase in cases reported in 2022, indicating a possible correlation with environmental factors like rising temperatures.
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Article Synopsis
  • Chronic HBV infection leads to severe liver disease and liver cancer, and new antiviral treatments like Capsid Assembly Modulators (CAMs) are needed but not fully understood in their mechanism of action.
  • Recent research demonstrates that CAM-A compounds reduce HBsAg levels and cause cell death in HBV-infected cells by promoting the aggregation of HBV core proteins (HBc) in the nucleus, triggering apoptosis.
  • Discovering that CAM-A facilitates HBc aggregation and activates apoptosis provides insights for developing new therapies aimed at effectively managing chronic HBV infections.
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Real Evidence: Real Life or Randomised Control Trials?

Eur J Vasc Endovasc Surg

October 2024

Department of Vascular Surgery, Kidney Transplantation and Innovation, Les Hôpitaux Universitaires de Strasbourg, University of Strasbourg, Strasbourg, France; GEPROMED, Strasbourg, France; Université de Strasbourg, Fédération de Médecine Translationelle (FMTS), Faculté de Médecine, Institut de Physiologie, Equipe d'Accueil EA3072 Mitochondrie, stress oxydant et protection musculaire, Strasbourg, France.

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Article Synopsis
  • The study focused on the average 3-day hospital stay after robotic-assisted partial nephrectomy (RAPN) and aimed to identify which patients could safely undergo the procedure on an outpatient basis without significant complications.
  • Researchers analyzed data from 3,342 patients who had RAPN between 2010 and 2021, finding that overall complications occurred in almost 15% of cases, with significant complications occurring in about 3.6%.
  • Key risk factors for early significant complications within 72 hours post-surgery included longer clamping times and higher ASA scores, leading to the conclusion that patients with ASA scores greater than 2 and a clamping time under 20 minutes could be good candidates for outpatient surgery.
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Introduction: Neurological disorders (ND) have a high incidence in sub-Saharan Africa (SSA). In this region, systemic challenges of conventional medicine (CM) and cultural beliefs have contributed to a large utilization of traditional medicine (TM). Yet, data on TM and those who use it in the treatment of ND in SSA are scarce.

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Mechanical complications during central catheterisation occur in approximately 15% of cases. This report describes a potentially fatal yet avoidable complication and highlights the typical radiological features of a retropharyngeal haematoma.A patient with acute myeloid leukaemia was admitted to the intensive care unit with respiratory distress immediately after an attempt to insert a subclavian catheter without ultrasound guidance.

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[Cerebromeningeal amyloid angiopathy].

Ann Pathol

November 2024

Département de pathologie, hôpitaux universitaires de Strasbourg, Strasbourg, France. Electronic address:

Amyloid angiopathy represents 20% of causes of intraparenchymal hematoma. The histopathological examination must carefully look for characteristic vascular abnormalities and the immunohistochemistry for the βA4 peptide must be carried out systematically. In practice, the evacuation products of an intracerebral hematoma must be fully included, because the lesions may be focal.

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Article Synopsis
  • A web-based ecological momentary assessment (EMA) tool was developed to monitor symptoms in patients with Sjögren's disease (SjD), focusing on daily variability in symptoms over three months.
  • The study involved 45 participants, primarily women, who recorded their symptoms through the WebApp, allowing comparisons with traditional paper questionnaires.
  • Results showed a high level of user satisfaction (SUS score of 90) and effective symptom tracking, confirming the tool's usefulness for accurately capturing daily experiences of SjD patients.
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Epileptic variant in the spectrum of Alzheimer's disease - practical implications.

Seizure

September 2024

Centre Mémoire, de Ressources et de Recherche de Strasbourg, France; Unité de Neuropsychologie, Service de Neurologie des Hôpitaux Universitaires de Strasbourg, Strasbourg, France; University of Strasbourg and CNRS, ICube laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), team IMIS/Neurocrypto Strasbourg, France; Centre de Compétences des démences rares des Hôpitaux Universitaires de Strasbourg, France. Electronic address:

Article Synopsis
  • Alzheimer's disease (AD) is linked to a higher risk of epilepsy, not only in its advanced stages (dementia) but also during earlier phases like mild cognitive impairment.
  • Epileptic seizures can even appear in the preclinical stage of AD, leading to a specific condition called the epileptic variant of Alzheimer's disease (evAD), which may be the only visible sign of the disease at that time.
  • Diagnosing evAD relies on examining amyloid and tau biomarkers and represents a crucial opportunity for early intervention with antiseizure medications to help slow down cognitive decline associated with AD.
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Immunopathogenesis of systemic lupus erythematosus: An update.

Autoimmun Rev

October 2024

Service d'immunologie Clinique et de médecine interne, Hôpitaux Universitaires de Strasbourg, Centre National de Référence des Maladies Systémiques Auto-immunes Rares, Strasbourg, France.

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by dysregulated immune responses leading to widespread inflammation and damage in various organs. Environmental factors such as infections, hormonal influences and exposure to ultraviolet light can trigger the disease in genetically predisposed individuals. Genome-wide association studies have identified over 100 susceptibility loci linked to immune regulation, interferon (IFN) signaling and antigen presentation in SLE.

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[Embryo reduction in twin pregnancy on maternal request: A French practice study].

Gynecol Obstet Fertil Senol

September 2024

Service de gynécologie obstétrique, hôpital américain de Paris, 5, boulevard du Château, 92200 Neuilly-sur-Seine, France. Electronic address:

Introduction: In France, embryo reduction is controversial in twin pregnancy, especially when there is no underlying pathology. The objective of this study was to establish the status of this practice in France and to depict the ethical issues around this problematic.

Study Design: A questionnaire drafted by Maternal and Fetal Medicine physicians and family planning teams of the University Hospital from Strasbourg was distributed to the 48 French Multidisciplinary Prenatal Diagnosis Centers, among which 28 answered (58,3%).

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Effects of Losartan on Patients Hospitalized for Acute COVID-19: A Randomized Controlled Trial.

Clin Infect Dis

September 2024

Division of Critical Care Medicine, and Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, Canada.

Article Synopsis
  • Researchers investigated the effect of losartan, an angiotensin receptor blocker, on 28-day mortality in hospitalized COVID-19 patients compared to usual care, due to its potential impact on angiotensin levels.
  • The study was stopped early due to safety concerns, showing that adverse events and hypotension were significantly higher in the losartan group (39.8% SAEs and 30.4% hypotension) versus the control group (27.2% SAEs and 15.3% hypotension).
  • There was no significant difference in 28-day mortality (6.5% for losartan vs. 5.9% for usual care), indicating that ARBs should be used cautiously in this patient population to
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