1,124 results match your criteria: "Hopitaux universitaires Henri Mondor[Affiliation]"
Risk of Incident Cancer in Patients with Inflammatory Bowel Disease with Prior Breast Cancer: A Multicenter Cohort Study.
Clin Gastroenterol Hepatol
November 2024
Department of Gastroenterology, Bicêtre University Hospital, AP-HP, Universite Paris Saclay, INSERM CESP, Le Kremlin Bicêtre, Le Kremlin Bicêtre, France.
Background & Aims: Breast cancer is the most common malignancy observed in patients with inflammatory bowel diseases (IBD). The aim of our study was to evaluate incident cancer rate (recurrence or new-onset cancer) in a cohort of patients with IBD with a history of breast cancer according to the subsequent IBD treatment provided.
Methods: A multicenter retrospective study included consecutive patients with IBD with prior breast cancer.
-related myopathies: clinical, myopathological and genotypic spectrum in a multicentre French cohort.
J Neurol Neurosurg Psychiatry
October 2024
Filière nationale, FILNEMUS, France.
Background: Myosin heavy chain 7 ()-related myopathies (-RMs) are a group of muscle disorders linked to pathogenic variants in the gene, encoding the slow/beta-cardiac myosin heavy chain, which is highly expressed in skeletal muscle and heart. The phenotype is heterogeneous including distal, predominantly axial or scapuloperoneal myopathies with variable cardiac involvement.
Methods: We retrospectively analysed the clinical, muscle MRI, genetic and myopathological features of 57 patients.
Does spastic myopathy determine active movement and ambulation speed in chronic spastic paresis?-A cross-sectional study on plantar flexors.
PLoS One
October 2024
UR 7377 BIOTN, Laboratoire Analyse et Restauration du Mouvement, Université Paris Est Créteil (UPEC), Créteil, France.
Background: Functional correlates of spastic myopathy, the muscle disorder of spastic paresis, are unknown.
Objective: To explore reciprocal relationships between clinical and structural parameters of plantar flexors with i) ambulation speed, ii) dorsiflexion and plantarflexion torques in chronic hemiparesis.
Methods: Cross-sectional trial in chronic stroke-induced hemiparesis (>6 months).
Genotypic and phenotypic characterisation of respiratory syncytial virus after nirsevimab breakthrough infections: a large, multicentre, observational, real-world study.
Lancet Infect Dis
October 2024
Virology Department, Hôpital Ambroise Paré, Paris, France. Electronic address:
Article Synopsis
- A study conducted in France during the 2023-24 RSV season analyzed the effectiveness of nirsevimab, a monoclonal antibody, in preventing RSV infections in infants, focusing on breakthrough cases.
- Out of 695 RSV-infected infants, researchers sequenced the full-length RSV genome of 545 infants, identifying that 48% had breakthrough infections despite receiving nirsevimab.
- While no resistance was found in RSV-A infections from nirsevimab-treated infants, two cases of RSV-B showed substitutions linked to resistance, indicating a potential concern for the antibody's effectiveness against this variant.
Mucosal nirsevimab levels in respiratory syncytial virus breakthrough bronchiolitis.
Lancet Infect Dis
November 2024
CIRI-Centre International de Recherche en Infectiologie, Team GIMAP, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530, CIC 1408 Vaccinology, F42023 Saint-Etienne, France; Immunology Department, University Hospital of Saint-Etienne, Saint-Etienne, France. Electronic address:
Pallidal neuronal activity in Gilles de la Tourette syndrome and dystonic patients: A comparative study.
Eur J Neurosci
November 2024
Inserm 1127, Sorbonne Université, UPMC Univ Paris 06, UMRS 1127, CNRS, UMR 7225, Paris Brain Institute, Paris, France.
Article Synopsis
- * It found that GTS patients exhibited higher firing rates and burst activity, while DYS patients showed more pauses and burst frequency, highlighting distinct neuronal activity patterns between the two disorders.
- * The research suggests a need for further studies on neuronal behavior in the GPi to improve DBS techniques and tailor treatments for better clinical outcomes in patients with hyperkinetic movement disorders.
Exceptional improvement in chronic stroke through Guided Self-rehabilitation Contract: a case report study.
Front Rehabil Sci
September 2024
AP-HP, Service de Rééducation Neurolocomotrice, Unité de Neurorééducation, Hôpitaux Universitaires Henri Mondor, Créteil, France.
Article Synopsis
- * After 16 months, she initiated a guided self-rehabilitation program where a therapist prescribed specific stretching and movement exercises targeting seven muscle groups to help regain function in her left arm.
- * Over four years, she consistently practiced the rehabilitation exercises for over two hours daily and fully regained use of her left arm, returning to work as a nurse's aide, with brain imaging confirming motor activity in her primary motor areas during left-hand use.
Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas.
Nat Commun
October 2024
Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.
Article Synopsis
- Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a diverse and challenging type of cancer that often has poor outcomes, especially in younger patients lacking the SMARCB1 protein.
- Research indicated that human and mouse PTCL-NOS exhibit similar DNA changes, including the hypermethylation of T-cell genes and the hypomethylation of myeloid development genes, contributing to a complicated tumor ecosystem.
- A study found that histone deacetylase inhibitors (HDACi), like SAHA, can effectively treat PTCL-NOS by modifying the tumor's microenvironment and improving immune function, paving the way for potential combination therapies.
Use of Botulinum Toxin in Upper-Limb Tremor: Systematic Review and Perspectives.
Toxins (Basel)
September 2024
Assistance Publique Hôpitaux de Paris, Service de Rééducation Neurolocomotrice, Hôpitaux Universitaires Henri Mondor, F-94010 Créteil, France.
Article Synopsis
- Tremor is the most common movement disorder, and while oral medications often have limited effectiveness due to side effects, botulinum toxin (BT) shows promise for improving upper limb function, although strong evidence is still lacking.
- A systematic review analyzed existing studies on BT for upper-limb tremor, finding only eight randomized controlled trials and seven open-label studies with small sample sizes, indicating that tailored injections based on individual needs lead to better outcomes.
- While BT injections can improve functionality, they may cause temporary weakness, particularly in wrist and finger movements; the review suggests optimizing injection techniques to minimize weakness and enhance effectiveness in treating tremors.
Authors' Reply to "Membrane Exchange During ECMO Is Risky Business, But Can It Be Avoided?".
ASAIO J
September 2024
Assistance publique des hôpitaux de Paris, Hôpitaux Universitaires Henri-Mondor Service de Médecine Intensive Réanimation Créteil, Créteil, France.
Letter to the editor for the article "Pilot study for bladder cancer detection with volatile organic compounds using ion mobility spectrometry: a novel urine-based approach".
World J Urol
September 2024
Department of Urology, AP-HP, Hopitaux Universitaires Henri Mondor, University of Paris-Est Creteil, Créteil, France.
Frailty in heart failure according to the presence or absence of wild-type transthyretin cardiac amyloidosis.
ESC Heart Fail
September 2024
INSERM, IMRB, Univ Paris Est Creteil, Creteil, France.
Aims: Wild-type transthyretin cardiac amyloidosis (ATTRwt CA) is a common, underdiagnosed cause of heart failure (HF) in the elderly. Concurrent extracardiac amyloid infiltration might be responsible for a specific frailty phenotype. This study aims to compare the prevalence and characteristics of frailty parameters in HF patients, with or without ATTRwt CA.
View Article and Find Full Text PDFPublication productivity of pathology residents: a nationwide cohort study in France.
Virchows Arch
September 2024
Pathology Department, Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, Créteil, F-94010, France.
The publication productivity of residents has been reported in various specialties, mainly in North America, but never in pathology. In France, pathology residents must defend a medical thesis to obtain the title of medical doctor and to practice medicine. The aim of this study was to assess the thesis performance and publication output of a nationwide cohort of pathology residents from six graduating classes in France.
View Article and Find Full Text PDFEltrombopag in chronic myelomonocytic leukemia with severe thrombocytopenia. A Groupe Francophone des Myélodysplasies (GFM) study.
Leukemia
November 2024
Hematology Department, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France.
A shock with skin necrosis is not always necrotising soft tissue infection.
Br J Haematol
October 2024
Service d'Anesthésie-Réanimation et Médecine Péri-opératoire, Faculté de Santé, DMU CARE, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Henri Mondor, Univ Paris Est Créteil, Créteil, France.
Metagenomics Applied to the Respiratory Mycobiome in Cystic Fibrosis.
Mycopathologia
September 2024
Unité de Parasitologie-Mycologie, Département de Prévention, Diagnostic et Traitement des Infections, Hôpitaux Universitaires Henri Mondor, Assistance Publique des Hôpitaux de Paris (APHP), Créteil, France.
Cystic fibrosis (CF) is a genetic disorder characterized by chronic microbial colonization and inflammation of the respiratory tract (RT), leading to pulmonary exacerbation (PEx) and lung damage. Although the lung bacterial microbiota has been extensively studied, the mycobiome remains understudied. However, its importance as a contributor to CF pathophysiology has been highlighted.
View Article and Find Full Text PDFPathophysiology and Prevention of Ventriculostomy-Related Infections: A Review.
Neurosurgery
September 2024
Department of Anaesthesiology and Critical Care, Georges Pompidou European Hospital, Paris, France.
This qualitative review aims to summarize current knowledge on ventriculostomy-related infection (VRI) pathophysiology and its prevention. VRI generally occurs at day 10, mainly because of Gram-positive cocci, after a cerebrospinal fluid leak. Skin microbiota and biofilm seem to play a major role in VRI pathogenesis.
View Article and Find Full Text PDFLow-dose interleukin-2 in patients with bipolar depression: A phase 2 randomised double-blind placebo-controlled trial.
Brain Behav Immun
January 2025
Sorbonne Université, INSERM, UMR_S 959, Immunology-Immunopathology- Immunotherapy (i3), F-75651 Paris, France; AP-HP, Pitié-Salpêtrière Hospital, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (i2B), F-75651 Paris, France. Electronic address:
Article Synopsis
- Scientists noticed that people with bipolar disorder, especially when they're sad, have problems with their immune system.
- In a study, they tested a medicine called IL-2 to see if it could help these people's moods by boosting a specific part of their immune system.
- The results showed that the IL-2 treatment was safe and helped improve mood in patients with bipolar depression.
Aortic arch registry of type a aortic dissection (AoArch) - rationale, design and definition criteria.
J Cardiothorac Surg
September 2024
Department of Cardiothoracic Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, 45267-0558, USA.
Article Synopsis
- Type A acute aortic dissection (TAAAD) is a serious medical emergency requiring immediate surgical intervention, and understanding treatment options is crucial for improving patient outcomes.
- A multicenter observational registry called AoArch has been established, combining data from four cardiac surgery centers in Europe to analyze the effects of hemiarch repair (HAR) versus extended arch repair (EAR) on patient outcomes following TAAAD surgery.
- The study will assess various factors, such as patient co-morbidities and surgical strategies, to measure both early and late adverse events, with a focus on defining mortality rates and complications related to TAAAD treatments.
Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy.
N Engl J Med
January 2025
From the National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital (M.F., J.D.G.), and Richmond Pharmacology (J.T.), London, and the Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, Glasgow (M.C.P.) - all in the United Kingdom; Boston University School of Medicine (J.L.B.) and the Cardiovascular Division, Brigham and Women's Hospital (S.D.S.) - both in Boston; the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA (R.M.W.); the Department of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN (M.G.); the Division of Cardiology, Penn Presbyterian Medical Center, University of Pennsylvania Health System, Philadelphia (B.D.); the Cardiology Department and French National Reference Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute and Clinical Investigation Centre 1430 at Hôpitaux Universitaires Henri-Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), and Institut Mondor de Recherche Biomédicale, INSERM, Université Paris Est Creteil, Creteil (T.D.), and the Department of Cardiology, French National Reference Center for Cardiac Amyloidosis, Bichat University Hospital, AP-HP, Paris (V.A.) - all in France; the Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, Health Research Institute of the Puerta de Hierro Majadahonda-Segovia, Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBER-CV), and Centro Nacional de Investigaciones Cardiovasculares (P.G.-P.), and CIBER-CV (J.G.-C.), Madrid, and the Department of Cardiology, Hospital Universitari de Bellvitge, Instituto de Investigación Biomédica de Bellvitge, and Universitat de Barcelona, Barcelona (J.G.-C.) - all in Spain; MedStar Heart and Vascular Institute, MedStar Health, and Georgetown University School of Medicine - both in Washington, DC (F.H.S.); the Division of Cardiovascular Medicine, Department of Medicine, Kurume University School of Medicine, Kurume (N.T.), and the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto (K.T.) - both in Japan; the Department of Clinical Research and Epidemiology, Comprehensive Heart Failure Center, University Hospital Würzburg, and the Department of Medicine I, University Hospital Würzburg, Würzburg (C.M.), and the Division of Cardiovascular Imaging, University Hospital Münster, Münster (A.Y.) - both in Germany; the Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary (Z.P.); the Department of Cardiology, University Health Network of Toronto, Toronto (D.D.); University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (P.V.M.); the Victor Chang Cardiac Research Institute, the Cardiology Department, St. Vincent's Hospital, and the School of Clinical Medicine, University of New South Wales - all in Sydney (A.J.); the Department of Cardiology, Hôpital Universitaire de Bruxelles-Hôpital Erasme, Université Libre de Bruxelles, Brussels (A.B.); the Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea (D.K.); the Cardiology Department, Hospital Senhora da Oliveira-Guimarães, Guimarães, and the School of Medicine, University of Minho, Braga - both in Portugal (O.A.); the Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (S.H.P.); the Division of Translational Cardiology and Clinical Registries, Institute of Heart Diseases, Wrocław Medical University, Wrocław, Poland (E.A.J.); Alnylam Pharmaceuticals, Cambridge, MA (A.S., P.P.G., K.L.B., E.Y., N.S., L.Y., J.C., S.A.E., J.V.); and Columbia University Irving Medical Center, New York (M.S.M.).
Article Synopsis
- Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a serious, progressive disease, and vutrisiran is a new treatment that works by reducing the production of transthyretin in the liver.
- In a double-blind trial involving 655 patients, those receiving vutrisiran had a lower risk of death and cardiovascular events compared to those on placebo, demonstrating significant efficacy.
- Vutrisiran also improved patient outcomes, showing less decline in walking distance and quality of life measurements over the study period compared to placebo.
Article Synopsis
- The study aimed to assess the prevalence and characteristics of transthyretin amyloid cardiomyopathy (ATTR-CM) in older patients with hypertrophic cardiomyopathy of unknown causes, amidst rising recognition of this condition due to better diagnostic techniques.
- Conducted across 20 hospitals in 11 countries, the TTRACK study included patients aged 50 and older with specific echocardiography findings, who underwent imaging tests to evaluate cardiac involvement.
- Results showed that 18.8% of patients had transthyretin amyloid cardiomyopathy, with notable findings including a correlation to symptoms of heart failure and a significant association with carpal tunnel syndrome among patients.
Efficacy and tolerance of brexucabtagene autoleucel in adults with R/R B-ALL: a GRAALL study from the DESCAR-T registry.
Blood Adv
November 2024
Hematology Adolescents and Young Adult Division, Saint-Louis Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France.
A 24/7 Pilot Remote Emergency Multidisciplinary Discussion for Rapidly Progressive Interstitial Lung Disease: A 2-Year Experience.
Chest
January 2025
Service de Pneumologie, Université Sorbonne Paris Nord, Assistance Publique-Hôpitaux de Paris, Hôpital Avicenne, Bobigny, France; Université Sorbonne Paris Nord, INSERM U1272, Paris, France.
Incidence, Risk Factors, and Long-Term Outcomes for Extubation Failure in ICU in Patients With Obesity: A Retrospective Analysis of a Multicenter Prospective Observational Study.
Chest
January 2025
Anesthesia and Critical Care Department B, Saint Eloi Teaching Hospital, PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, and Centre Hospitalier Universitaire Montpellier, Montpellier, France. Electronic address:
Background: To our knowledge, no large observational study has compared the incidence and risk factors for extubation failure within 48 h and during ICU stay in the same cohort of unselected critically ill patients with and without obesity.
Research Question: What are the incidence and risk factors of extubation failure in patients with and without obesity?
Study Design And Methods: In the prospective multicenter observational Practices and Risk Factors for Weaning and Extubation Airway Failure in Adult Intensive Care Unit: A Multicenter Trial (FREEREA) study in 26 ICUs, the primary objective was to compare the incidence of extubation failure within 48 h in patients with and without obesity. Secondary objectives were to describe and to identify the independent specific risk factors for extubation failure using first a logistic regression model and second a decision tree analysis.