743 results match your criteria: "Hopital universitaire des Enfants Reine Fabiola[Affiliation]"

Thoracic postoperative complications are difficult to diagnose on supine chest X-rays, with pneumothoraxes accompanied by underlying atelectasis presenting as non-specific opacities due to the superposition of the two entities having opposed radiographic characteristics, with one causing lucency and the other opacity.

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Article Synopsis
  • Many SGA (small for gestational age) patients have particular syndromes that can complicate understanding their response to rhGH (recombinant human growth hormone) treatment; this study examines these patients and their growth outcomes.
  • The study analyzed 272 SGA patients in Belgium, identifying 42 with syndromic conditions, which made them generally younger, shorter, and thinner when they began rhGH treatment compared to non-syndromic patients.
  • While both groups had similar initial responses to rhGH, syndromic patients showed different growth patterns, gaining more height before puberty but less during puberty, and still had lower average adult heights compared to non-syndromic patients.
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Background: () remains a major cause of gastroduodenal diseases. We aimed to evaluate the burden of this infection, particularly peptic ulcer disease in Vietnamese children.

Methods: We enrolled consecutive children referred for esophagogastroduodenoscopy at two tertiary children's hospitals in Ho Chi Minh City, from October 2019 to May 2021.

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Background: We assessed the mental health of children and adolescents aged 7 to 17 and their parents immediately after the first wave of the COVID-19 pandemic.

Method: A survey online was conducted in Belgium between May 29th and August 31st 2020.

Results: (1) Anxious and depressive symptoms were self-reported by one out of four children and hetero-reported by parents for one out of five children; (2) Anxiety scores were higher in children compared to adolescents; (3) Social introversion scores were significantly higher in adolescents compared to children; (4) No significant differences for anxio-depressive symptoms were found between healthcare worker parents and the other parents.

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Gaucher disease represents the largest lysosomal storage disease group worldwide. Possible complications include the development of Gaucheromas, pseudotumors resulting from an accumulation of Gaucher cells. Gaucheromas can affect the liver, spleen, bones, and lymph nodes.

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Diffuse leptomeningeal glioneuronal tumours (DL-GNT) are rare, with an unknown incidence but fewer than 100 cases reported since 2012. The clinical presentation is non-specific, ranging from abdominal to neurological symptoms. Presently, definitive radiological criteria aren't established, but some features, such as nodules, characteristic extension patterns and post-contrast leptomeningeal enhancement, are found to be prominent.

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Background: Renal operational tolerance is a rare and beneficial state of prolonged renal allograft function in the absence of immunosuppression. The underlying mechanisms are unknown. We hypothesized that tolerance might be driven by inherited protein coding genetic variants with large effect, at least in some patients.

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The study aimed to identify prevalence of infection and associated risk factors among pupils of Ho Chi Minh city (HCMC). A total of 1,476 pupils aged 6-15 years were enrolled in this cross-sectional study using multiple-stage sampling method. Infection status was assessed using stool antigen-test.

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Background: Immunity to Streptococcus pyogenes in high burden settings is poorly understood. We explored S. pyogenes nasopharyngeal colonization after intranasal live attenuated influenza vaccine (LAIV) among Gambian children aged 24-59 months, and resulting serological response to 7 antigens.

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Eteplirsen is FDA-approved for the treatment of Duchenne muscular dystrophy (DMD) in exon 51 skip-amenable patients. Previous studies in boys > 4 years of age indicate eteplirsen is well tolerated and attenuates pulmonary and ambulatory decline compared with matched natural history cohorts. Here the safety, tolerability and pharmacokinetics of eteplirsen in boys aged 6-48 months is evaluated.

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Complications of Percutaneous and Surgical Gastrostomy Placements in Children: a Single-Centre Series.

JPGN Rep

May 2023

From the Paediatric Gastroenterology Department, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Brussels, Belgium.

Unlabelled: Gastrostomy placement is a standard procedure for children requiring enteral feeding for more than 3-6 weeks. Various techniques have been described (percutaneous endoscopic, laparoscopy, and laparotomy), and many complications have been reported. In our center, gastrostomy placement is performed either percutaneously by pediatric gastroenterologists, by laparoscopy/laparotomy by the visceral surgery team, or jointly, that is laparoscopic-assisted percutaneous endoscopic gastrostomy.

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Gonadal development and function after immature testicular tissue banking as part of high-risk gonadotoxic treatment.

Pediatr Blood Cancer

August 2023

Department of Reproduction, Genetics and Regenerative Medicine (RGRG), Biology of the Testis (BITE), Vrije Universiteit Brussel (VUB), Laarbeeklaan, Brussels, Belgium.

Background: Experimental fertility preservation programs have been started to safeguard the future fertility of prepubertal and pubertal males requiring high-risk gonadotoxic treatment protocols. However, long-term follow-up studies evaluating the effects on their gonadal development and function related to the testicular biopsy procedure are rather limited.

Design: This two-center follow-up study (between 2002 and 2020) evaluated the gonadal development and function of a cohort of 59 prepubertal and pubertal males who have been offered immature testicular tissue banking (TTB) prior to conventional high-risk chemo- and/or radiotherapy (HR-C/R) or conditioning therapy before hematopoietic stem cell transplantation (CT-HSCT).

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Blinatumomab Added to Chemotherapy in Infant Lymphoblastic Leukemia.

N Engl J Med

April 2023

From the Princess Máxima Center for Pediatric Oncology (I.M.S., P.E.S.-H., R.P.), and the Dutch Childhood Oncology Group (I.M.S., R.P.) - both in Utrecht, the Netherlands; Tettamanti Center (P.L.) and Biostatistics and Clinical Epidemiology (M.G.V.), Fondazione IRCCS San Gerardo dei Tintori, Monza, the School of Medicine and Surgery, University of Milano-Bicocca, Milan (M.G.V.), and the Department of Pediatric Hematology-Oncology and Cell and Gene Therapy, IRCCS Ospedale Pediatrico Bambino Gesù, Catholic University of the Sacred Heart, Rome (F.L.) - all in Italy; Australian and New Zealand Children's Hematology and Oncology Group, Perth Children's Hospital (R.S.K.), Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia (R.S.K.), and Curtin Medical School, Curtin University (R.S.K.) - all in Perth, WA, Australia; St. Anna Children's Hospital, Department of Pediatric Hematology and Oncology, Medical University of Vienna, and St. Anna Children's Cancer Research Institute - both in Vienna (A.A.); the German Cooperative Study Group for Childhood Acute Lymphoblastic Leukemia, Hamburg (G.E.) the Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg (G.E.), and the ALL-Berlin-Frankfurt-Münster (BFM) Group, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel (M.S.) - all in Germany; the Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University Hospital, Copenhagen (K.N.); Czech Working Group for Pediatric Hematology (J.S.) and CLIP (Childhood Leukemia Investigation Prague), Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol (J.S.) - all in Prague, Czech Republic; Hôpital Universitaire des Enfants Reine Fabiola, Brussels (A.F.); and the Department of Pediatric Hematology, University Robert Debre Hospital, Assistance Publique-Hôpitaux de Paris, Paris (B.B.).

Background: -rearranged acute lymphoblastic leukemia (ALL) in infants is an aggressive disease with 3-year event-free survival below 40%. Most relapses occur during treatment, with two thirds occurring within 1 year and 90% within 2 years after diagnosis. Outcomes have not improved in recent decades despite intensification of chemotherapy.

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[Imaging of posterior persistent fetal vasculature].

J Fr Ophtalmol

June 2023

Service d'ophtalmologie, hôpital universitaire des Enfants Reine-Fabiola, université Libre de Bruxelles, 15, avenue Jean-Joseph-Crocq, 1020 Bruxelles, Belgique.

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Previous studies have reported sex disparity in cystic fibrosis (CF) disease, with females experiencing more pulmonary exacerbations and frequent microbial infections resulting in shorter survival expectancy. This concerns both pubertal and prepubertal females, which is in support to the prominent role of gene dosage rather than the hormonal status. The underlying mechanisms are still poorly understood.

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Frontoparietal F-FDG-PET hypo-metabolism in Lennox-Gastaut syndrome: Further evidence highlighting the key network.

Epilepsy Res

May 2023

Department of Medicine, The University of Melbourne, Heidelberg, Victoria, Australia; The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Neurology, Austin Health, Heidelberg, Victoria, Australia. Electronic address:

Introduction: Lennox Gastaut syndrome (LGS) can be conceptualised as a "secondary network epilepsy", in which the shared electroclinical manifestations reflect epileptic recruitment of a common brain network, despite a range of underlying aetiologies. We aimed to identify the key networks recruited by the epileptic process of LGS using interictal 2-deoxy-2-(F)fluoro-D-glucose positron emission tomography (F-FDG-PET).

Methods: Group analysis of cerebral F-FDG-PET, comparing 21 patients with LGS (mean age = 15 years) and 18 pseudo-controls (mean age = 19 years), studied at Austin Health Melbourne, between 2004 and 2015.

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A pathogenic CTBP1 variant featuring HADDTS with dystrophic myopathology.

Neuromuscul Disord

May 2023

Centre de Référence Neuromusculaire, Pediatric Neurology department, Hôpital Universitaire des Enfants- Reine Fabiola (HUDERF), Université Libre de Bruxelles, Belgium; Centre de Référence Neuromusculaire, Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium. Electronic address:

HADDTS (Hypotonia, Ataxia, Developmental-Delay and Tooth-enamel defects) is a newly emerging syndrome caused by CTBP1 mutations. Only five reports (13 cases) are available; three contained muscle-biopsy results but none presented illustrated histomyopathology. We report a patient in whom whole-exome sequencing revealed a heterozygous de novo CTBP1 missense mutation (c.

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Article Synopsis
  • A 10-year-old boy had neck pain and symptoms affecting his arms, which lasted for 13 days.
  • Doctors found signs of transverse myelitis (TM) in his spine, and tests showed it was caused by Lyme disease.
  • After treatment with steroids and antibiotics, he got completely better, and doctors noted that Lyme TM usually has milder symptoms and often leads to full recovery in kids.
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Objectives: To improve adult height in pubertal girls with a poor height prediction, treatment with growth hormone (GH) can be used in combination with a gonadotropin releasing hormone agonist (GnRHa), to delay closure of the growth plates. However, there are few studies to support this practice, and they show conflicting results. The objective of this trial is to assess the safety and efficacy of this combination treatment in early pubertal girls with a short predicted height, in comparison with matched controls.

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Hereditary Tyrosinemia Type 1 Mice under Continuous Nitisinone Treatment Display Remnants of an Uncorrected Liver Disease Phenotype.

Genes (Basel)

March 2023

Liver Therapy & Evolution Team, In Vitro Toxicology and Dermato-Cosmetology (IVTD) Research Group, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, 1090 Brussels, Belgium.

Hereditary tyrosinemia type 1 (HT1) is a genetic disorder of the tyrosine degradation pathway (TIMD) with unmet therapeutic needs. HT1 patients are unable to fully break down the amino acid tyrosine due to a deficient fumarylacetoacetate hydrolase (FAH) enzyme and, therefore, accumulate toxic tyrosine intermediates. If left untreated, they experience hepatic failure with comorbidities involving the renal and neurological system and the development of hepatocellular carcinoma (HCC).

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Clinicopathological and molecular characterization of a case classified by DNA‑methylation profiling as "CNS embryonal tumor with BRD4-LEUTX fusion".

Acta Neuropathol Commun

March 2023

Department of Pathology, Université Libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), CUB Hôpital Erasme, Erasme University Hospital, Brussels, Belgium.

Central Nervous System (CNS) embryonal tumors represent a heterogeneous group of highly aggressive tumors occurring preferentially in children but also described in adolescents and adults. In 2021, the CNS World Health Organization (WHO) classification drastically changed the diagnosis of the other CNS embryonal tumors including new histo-molecular tumor types. Here, we report a pediatric case of a novel tumor type among the other CNS embryonal tumors classified within the methylation class "CNS Embryonal Tumor with BRD4-LEUTX Fusion".

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[Ocular manifestations of congenital toxoplasmosis].

J Fr Ophtalmol

April 2023

Service d'ophtalmologie, hôpital universitaire des Enfants Reine-Fabiola, 15, avenue Jean-Joseph-Crocq, 1020 Bruxelles, Belgique; Université Libre de Bruxelles, Bruxelles, Belgique.

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