Detection and verification of 2.3 million cancer mutations in NCI60 cancer cell lines with a cloud search engine.

Today we have unprecedented access to human genomic and proteomic data that appear to be rapidly approaching our current understanding of comprehensive coverage. Combining genomic information with shotgun proteomics remains challenging due to the large increase in proteomics search space. However, making this connection between genomic and proteomic information is critical for cancer studies to vaccine development.

Adolescent exposure to fluoxetine impairs serial pattern learning in the serial multiple choice (SMC) task in adult rats.

The effects of chronic adolescent fluoxetine (FLX, Prozac®) exposure on adult cognition are largely unknown. We used a serial multiple choice (SMC) task to characterize the effects of adolescent FLX exposure on rat serial pattern learning in adulthood. Male rats were exposed to either 1.

Tiger salamanders' (Ambystoma tigrinum) use of features.

In their environment, salamanders must avoid both predation and desiccation, necessitating efficient movement throughout their world. Although past research has indicated that salamanders can use visual cues in navigating through their environment, it is not clear how geometric and feature information are incorporated by salamanders in their movement through their surroundings. Past work with a variety of species indicates that geometric information is regularly used and that features are also used under some circumstances.

Photodynamics of [FeFe]-Hydrogenase Model Compounds with Bidentate Heterocyclic Ligands.

Two asymmetrically structured model compounds for the hydrogen-generating [Fe-Fe]-hydrogenase active site were investigated to determine the ultrafast photodynamics, structural intermediates, and photoproducts compared to more common symmetric di-iron species. The bidentate-ligand-containing compounds studied were Fe(μ-SCH)(CO)(bipy), , and Fe(μ-SCH)(CO)(phen), , in dilute room temperature acetonitrile solution and low-temperature 2Me-THF matrix isolation using static FTIR difference and time-resolved infrared spectroscopic methods (TRIR). Ultraviolet-visible spectra were also compared to time-dependent density functional theory (TD-DFT) to ascertain the orbital origins of long wavelength electronic absorption features.

The professionalization of psychologists as court personnel: Consequences of the first institutional commitment law for the "feebleminded".

The first law providing for the permanent, involuntary institutionalization of "feeble-minded" individuals was passed in Illinois in 1915. This bill represented the first eugenic commitment law in the United States. Focusing on the consequences of this 1915 commitment law within the context of intelligence testing, eugenics, and the progressive movement, this paper will argue that the then newly devised Binet-Simon intelligence test facilitated the definition and classification of feeble-mindedness that validated feeble-mindedness theory, enabled the state to legitimize the eugenic diagnosis and institutionalization of feeble-minded individuals, and especially empowered psychologists to carve out a niche for themselves in the courtroom as "experts" when testifying as to the feeble-mindedness of individuals.

Intraseasonal variation of E. coli and environmental covariates in two irrigation ponds in Maryland, USA.

The microbial quality of irrigation water is typically assessed by measuring the concentrations of E. coli in irrigation water reservoirs that are variable in space and time. E.

A Video Surveillance System to Monitor Breeding Colonies of Common Terns (Sterna Hirundo).

Many waterbird populations have faced declines over the last century, including the common tern (Sterna hirundo), a waterbird species with a widespread breeding distribution, that has been recently listed as endangered in some habitats of its range. Waterbird monitoring programs exist to track populations through time; however, some of the more intensive approaches require entering colonies and can be disruptive to nesting populations. This paper describes a protocol that utilizes a minimally invasive surveillance system to continuously monitor common tern nesting behavior in typical ground-nesting colonies.

Tiger salamanders' (Ambystoma tigrinum) response retention and usage of visual cues following brumation.

Brumation enables tiger salamanders (Ambystoma tigrinum) to survive changes in temperature. However, it is unclear how this affects memory retention. We explored how brumation impacted salamanders' retention of a learned response to a visual cue through two experiments.

Ultrafast Photodynamics of Cyano-Functionalized [FeFe] Hydrogenase Model Compounds.

[FeFe] hydrogenases are efficient enzymes that produce hydrogen gas under mild conditions. Synthetic model compounds containing all CO or mixed CO/PMe ligands were previously studied by us and others with ultrafast ultraviolet or visible pump-infrared probe spectroscopy in an effort to better understand the function and interactions of the active site with light. Studies of anionic species containing cyano groups, which more closely match the biological active site, have been elusive.

Absence of a Link Between Childhood Parental Military Service on Depression and Anxiety Disorders Among College Students.

Background: Current prevalence estimates are 15% for depression and 20% for anxiety disorders among college students. These disorders are known to negatively impact academic achievement and persistence. It is important to understand the effects of parental military service on the mental health of children across development.

Deep Vein Thrombosis in Acute Stroke - A Systemic Review of the Literature.

We present a systemic review of available literature on the complications of deep venous thrombosis that develops in patients presenting with acute stroke. There are several pharmacological and physical treatment options available and used. We aim to summarize the management plans currently used at different centers.

The effect of ad hominem attacks on the evaluation of claims promoted by scientists.

Two experiments were conducted to determine the relative impact of direct and indirect (ad hominem) attacks on science claims. Four hundred and thirty-nine college students (Experiment 1) and 199 adults (Experiment 2) read a series of science claims and indicated their attitudes towards those claims. Each claim was paired with one of the following: A) a direct attack upon the empirical basis of the science claim B) an ad hominem attack on the scientist who made the claim or C) both.

Femtosecond Laser Eyewear Protection: Measurements and Precautions.

Ultrafast laser systems are becoming more widespread throughout the research and industrial communities yet eye protection for these high power, bright pulsed sources still require scrupulous characterization and testing before use. Femtosecond lasers, with pulses naturally possessing broad-bandwidth and high average power with variable repetition rate, can exhibit spectral side-bands and subtly changing center wavelengths, which may unknowingly affect eyewear safety protection. Pulse spectral characterization and power diagnostics are presented for a 80 MHz, Ti:Sapphire, ≈ 800 nm, ≈40 femtosecond oscillator system.

A regional assessment of white-tailed deer effects on plant invasion.

Herbivores can profoundly influence plant species assembly, including plant invasion, and resulting community composition. Population increases of native herbivores, e.g.

Femtosecond Laser Eyewear Protection: Measurements and Precautions for Amplified High Power Applications.

Ultrafast lasers have become increasingly important as research tools in laboratories and commercial enterprises suggesting laser safety, personal protection and awareness become ever more important. Laser safety eyewear are typically rated by their optical densities (OD) over various spectral ranges, but these measurements are usually made using low power, large beam size, and continuous beam conditions. These measurement scenarios are vastly different than the high power, small beam size, and pulsed laser beam conditions where ultrafast lasers have extremely high peak powers and broad spectra due to the short pulse durations.

Photochemical Dynamics of a Trimethyl-Phosphine Derivatized [FeFe]-Hydrogenase Model Compound.

Though there have been many studies on photosensitizers coupled to model complexes of the [FeFe]-hydrogenases, few have looked at how the models react upon exposure to light. To extract photoreaction information, ultrafast time-resolved UV/visible pump, IR probe spectroscopy was performed on Fe(μ-SCH)(CO)(PMe) () dissolved in heptane and acetonitrile and the photochemical dynamics were determined. Excitation with 532 and 355 nm light produces bleaches and new absorptions that decay to half their original intensity with time constants of 300 ± 120 ps and 380 ± 210 ps in heptane and acetonitrile, respectively.

Temporal Stability of Escherichia coli Concentrations in Waters of Two Irrigation Ponds in Maryland.

Fecal contamination of water sources is an important water quality issue for agricultural irrigation ponds. concentrations are commonly used to evaluate recreational and irrigation water quality. We hypothesized that there may exist temporally stable spatial patterns of concentrations across ponds, meaning that some areas mostly have higher and other areas mostly lower than average concentrations of To test this hypothesis, we sampled two irrigation ponds in Maryland at nodes of spatial grids biweekly during the summer of 2016.

Salinity stress results in differential Hsp70 expression in the Exaiptasia pallida and Symbiodinium symbiosis.

Abiotic factors affect cnidarian-algal symbiosis and, if severe enough, can result in bleaching. Increased temperature and light are well characterized causes of bleaching, but other factors like salinity can also stress the holobiont. In cnidarian-dinoflagellate systems, the expression of host genes, including heat shock protein 70 (Hsp70), changes due to thermal and light stress.

Occupational pesticide exposure and subclinical hypothyroidism among male pesticide applicators.

Objectives: Animal studies suggest that exposure to pesticides may alter thyroid function; however, few epidemiologic studies have examined this association. We evaluated the relationship between individual pesticides and thyroid function in 679 men enrolled in a substudy of the Agricultural Health Study, a cohort of licensed pesticide applicators.

Methods: Self-reported lifetime pesticide use was obtained at cohort enrolment (1993-1997).

Recruiting African American Children for Research: An Ecological Systems Theory Approach.

With health disparities still pervasive and persistent in the United States, medical researchers and social scientists continue to develop recruitment strategies to increase the inclusion of racial/ethnic minority groups in research and interventions. Effective methods for recruiting samples of African American participants for pediatric research may be best understood when situated within an overarching conceptual model-one that serves to organize and explain effective recruitment strategies. A theoretical framework well suited for this purpose is Bronfenbrenner's ecological systems theory, which views individuals as influencing and being influenced by (both directly and indirectly) a series of interconnected social systems.

The effect of a faith community nurse network and public health collaboration on hypertension prevention and control.

Background: As part of the Association of State and Territorial Health Official's Million Hearts State Learning Collaborative in 2014 and 2015, Washington County, Maryland formed a collaboration between the local health department, health system and faith community nurse network to address the undiagnosed and uncontrolled hypertension in the county.

Objectives: Data were analyzed to determine the effect of a faith community nursing intervention of teaching blood pressure self-monitoring and coaching blood pressure and lifestyle changes in the at-risk and hypertensive population.

Methods: Thirty-nine faith community nurses offered a 3-month blood pressure self-monitoring and coaching intervention in 2014 and 2015 to 119 participants.

A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A.

Our initial discovery of 8-hydroxyquinoline inhibitors of BoNT/A and separation/testing of enantiomers of one of the more active leads indicated considerable flexibility in the binding site. We designed a limited study to investigate this flexibility and probe structure-activity relationships; utilizing the Betti reaction, a 36 compound matrix of quinolinol BoNT/A LC inhibitors was developed using three 8-hydroxyquinolines, three heteroaromatic amines, and four substituted benzaldehydes. This study has revealed some of the most effective quinolinol-based BoNT/A inhibitors to date, with 7 compounds displaying IC values ⩽1μM and 11 effective at ⩽2μM in an ex vivo assay.

Replication Rate, Framing, and Format Affect Attitudes and Decisions about Science Claims.

A series of five experiments examined how the evaluation of a scientific finding was influenced by information about the number of studies that had successfully replicated the initial finding. The experiments also tested the impact of frame (negative, positive) and numeric format (percentage, natural frequency) on the evaluation of scientific findings. In Experiments 1 through 4, an attitude difference score served as the dependent measure, while a measure of choice served as the dependent measure in Experiment 5.

Prevalence of DSM-IV intermittent explosive disorder in Black adolescents: Findings from the National Survey of American Life, Adolescent Supplement.

Little is known about the epidemiology of (4th ed.; ) intermittent explosive disorder (IED) in adolescents, and no information is currently available regarding the relationship between race/ethnicity and IED among Black youth in the United States. Using the World Health Organization World Mental Health Composite International Diagnostic Interview (Adolescent Version), we estimated the prevalence, severity, and disability of IED in a national, probability sample of African American and Caribbean Black youth (ages 13–17) from the National Survey of American Life, Adolescent Supplement.