DNA protective effect of ginseng and the antagonistic effect of Chinese turnip: A supplementation study.

Aim: The aim of this clinical study is to provide scientific evidence for supporting traditional Chinese application and usage to the patients. For this purpose, we tested the ability if Panax ginseng extract to lower oxidative damage to nuclear DNA in human lymphocytes by comparing the effect of cooked Chinese turnip on this effect.

Materials And Methods: Seven healthy subjects (4 males and 3 females from 37 to 60 years) participated two occasions which were at least 2 weeks apart.

Rapid but mild genoprotective effect on lymphocytic DNA with Panax notoginseng extract supplementation.

Background: Panax notoginseng (PN) is a well-known Chinese medicinal herb traditionally used as a hemostatic agent that strengthens and builds blood. The free radicals scavenging and antioxidant property of PN have been demonstrated in various studies either in vitro or in animal models, however, the genoprotective effect at human cellular level remains to be elucidated.

Aim: The current supplementation study aimed to investigate the genoprotective effect of PN.

American ginseng tea protects cellular DNA within 2 h from consumption: results of a pilot study in healthy human volunteers.

The acute genoprotective effect of Panax quinquefolius (American ginseng) has been investigated. The experiment was carried out to explore the DNA protective effect after a single dose of American ginseng tea bag infusion. Fourteen subjects (6 males and 8 females) were recruited in this study.

Genoprotective effect of the Chinese herbal decoction xiao jian zhong tang.

The Chinese herbal decoction formula Xiao Jian Zhong Tang (XJZT) is one of the classic formulas from the classic traditional Chinese medicine (TCM). Previous studies on XJZT found that it is effective for treating peptic ulcer, irritable bowel syndrome, functional gastroenteritis and similar psychosomatic disorders of the digestive organs. It has also been shown that all the herbs used in XJZT contain antioxidants.

A study of DNA protective effect of orange juice supplementation.

The potential acute genoprotective effect of orange juice supplementation was investigated. Six healthy subjects (aged 33 to 60 years; 3 women and 3 men) were asked to drink 400 mL of commercial orange juice, which contained 100 mg vitamin C and 40.8 g sugar.

Direct human DNA protection by Coriolus versicolor (Yunzhi) extract.

Context And Objective: Scientific evidence has shown Coriolus versicolor (L. ex Fr.) Quel (also known as Yunzhi) has the role of immunomodulator in therapeutic effect.

Protective effect of grape seed extracts on human lymphocytes: a preliminary study.

Grape seed extracts (GSEs) possess a broad spectrum of antioxidative properties that protects various cells from free radicals and oxidative stress. In this study, the genoprotective effect of GSE on human lymphocytic DNA was studied using standard and lysed cell comet assays. Lymphocytes from 5 healthy subjects were pretreated with GSE in different concentrations.

Optimized noninvasive procedures to measure DNA damage in comet assay.

The comet assay is a well-established, simple and sensitive method to measure DNA damage in single cell and is commonly used in human trials to investigate the effects of pollution, occupational hazards and potential genoprotective agents. Peripheral blood lymphocytes are most commonly used in human biomonitoring studies, but lymphocytes collected from the mouth offer a potentially attractive, noninvasive alternative. The aim of the current study was to develop a buccal cell lymphocyte comet assay procedure.

In vitro antioxidation activity and genoprotective effect of selected Chinese medicinal herbs.

Some traditional Chinese medicinal seeds and fruits are well known for their antioxidant properties. This research aims to investigate whether Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi and Semen Cuscutae protect DNA from oxidant challenge by hydrogen peroxide (H(2)O(2)). The standard comet assay was used to assess the genoprotective effect of these medicinal herbs.

DNA protective effect of ginseng and the antagonistic effect of Chinese turnip: a preliminary study.

The genoprotective effect of American and Asian ginseng on human lymphocytic DNA was studied. Using the comet assay, aqueous extracts of both types of ginseng were shown to diminish hydrogen peroxide-induced DNA damage. In contrast, and in accordance with traditional Chinese medicine beliefs, addition of the juice from Chinese turnip counteracted the beneficial effect of ginseng.