Disentangling Sources of Momentum Fluctuations in Xe+Xe and Pb+Pb Collisions with the ATLAS Detector.

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

Measurement of CP Violation Observables in D^{+}→K^{-}K^{+}π^{+} Decays.

A search for violation of the charge-parity (CP) symmetry in the D^{+}→K^{-}K^{+}π^{+} decay is presented, with proton-proton collision data corresponding to an integrated luminosity of 5.4  fb^{-1}, collected at a center-of-mass energy of 13 TeV with the LHCb detector. A novel model-independent technique is used to compare the D^{+} and D^{-} phase-space distributions, with instrumental asymmetries subtracted using the D_{s}^{+}→K^{-}K^{+}π^{+} decay as a control channel.

Intelligent Hierarchical Targeting Near-Infrared Persistent Luminescence Nanosystem for Improved Nuclear Delivery and Simultaneous Visualization/Therapy of EBV-Associated Cancer.

Epstein-Barr nuclear antigen 1 (EBNA1), a sequence-specific DNA binding protein of Epstein-Barr virus (EBV), is essential for viral genome replication and maintenance and is therefore an attractive target for the therapeutic intervention of EBV-associated cancers. Several EBNA1-specific inhibitors have demonstrated the ability to block EBNA1 function in vitro, but practical delivery strategies for these inhibitors in vivo are still lacking. Here, we report an intelligent hierarchical targeting theranostic nanosystem (denoted as mZGOCS@MnO-P5) that integrates an azide (N3) terminal dual-targeting peptide (N3-P5), a tumor microenvironment-responsive degradable MnO nanosheet, and a mesoporous ZnGaO:Cr, Sn near-infrared persistent luminescence (NIR-PL) nanosphere (mZGOCS).

Imaging interlayer exciton superfluidity in a 2D semiconductor heterostructure.

Excitons, which are Coulomb bound electron-hole pairs, are composite bosons and thus at low temperature can form a superfluid state with a single well-defined amplitude and phase. We directly image this macroscopic exciton superfluid state in an hBN-separated MoSe-WSe heterostructure. At high density, we identify quasi-long-range order over the entire active area of our sample, through spatially resolved coherence measurements.

Bola-Amphiphilic Dendrimer Enhances Imatinib to Target Metastatic Ovarian Cancer via β-Catenin-HRP2 Signaling Axis.

Ovarian cancer is the leading cause of death among all gynecological malignancies, and drug resistance renders the current chemotherapy agents ineffective for patients with advanced metastatic tumors. We report an effective treatment strategy for targeting metastatic ovarian cancer involving a nanoformulation (Bola/IM)─bola-amphiphilic dendrimer (Bola)-encapsulated imatinib (IM)─to target the critical mediator of ovarian cancer stem cells (CSCs) CD117 (c-Kit). Bola/IM offered significantly more effective targeting of CSCs compared to IM alone, through a novel and tumor-specific β-catenin/HRP2 axis, allowing potent inhibition of cancer cell survival, stemness, and metastasis in metastatic and drug-resistant ovarian cancer cells.

Contrasting Responses of Smoke Dispersion and Fire Emissions to Aerosol-Radiation Interaction during the Largest Australian Wildfires in 2019-2020.

The record-breaking 2019-2020 Australian wildfires have been primarily linked to climate change and its internal variability. However, the meteorological feedback mechanisms affecting smoke dispersion and wildfire emissions on a synoptic scale remain unclear. This study focused on the largest wildfires occurring between December 25, 2019 and January 10, 2020, under the enhanced subtropical high, when the double peak in wildfire evolution was favored by sustained low humidity and two synchronous increases in temperature and wind.

A novel quantitative angiogenesis assay based on visualized vascular organoid.

Angiogenesis describes the sprouting of blood vessels from existing vasculatures and it plays a pivotal role in disease progress such as diabetes, age-related macular degeneration and cancer. However, the most widely used anti-angiogenic agents targeting vascular endothelial growth factor (VEGF) pathway still lacked of specificity and therapeutic efficacy. To establish a method suitable for high-throughput drug screening and faithfully recapitulate the feature of in vivo angiogenesis, we generated a PECAM1-mRuby3-secNluc; ACTA2-EGFP dual reporter human pluripotent stem cell (hPSC) line and utilizing the cell line to establish a visualized and quantifiable in vitro angiogenesis model with stem cell-derived vascular organoid.

Basic Science and Pathogenesis.

Background: Neurogranin (Ng) is considered a biomarker for synaptic dysfunction in Alzheimer's disease (AD). In contrast, the inflammasome complex has been shown to exacerbate AD pathology.

Method: We investigated the protein expression, morphological differences of Ng and correlated Ng to hyperphosphorylated tau in the postmortem brains of 17 AD cases and 17 age and sex-matched controls.

Basic Science and Pathogenesis.

Background: Nucleotide-binding domain and leucine-rich repeat (LRR)-containing family protein 3 (NLRP3) is involved in neuroinflammation in Alzheimer's Disease (AD). Single nucleotide polymorphisms (SNPs) in the NLRP3 gene are associated with the risk of AD in different populations, however the relationship between NLRP3 SNPs and Hong Kong population has not been studied.

Method: In this study,12 intron SNPs and 2 exon SNPs were genotyped in 233 healthy controls and 323 mild cognitive impairments (MCI) patients from Hong Kong.

Basic Science and Pathogenesis.

Background: The efficacy of Calorie Restriction (CR) in enhancing cognition, promoting healthy aging, and extending lifespan is well-established. Yet, it remains unclear whether the apolipoprotein E (APOE) genotype, a known modifier for aging and age-related disorders, influences the beneficial effects of CR in countering aging.

Methods: To investigate this question, we utilized humanized APOE mouse models, which express APOE2, APOE3, or APOE4 alleles systematically (refer to as E2, E3, and E4 mice).

Curcumin/kaolin composite for advanced latent fingerprint imaging with fluorescence quantification.

Latent fingerprints (LFPs) are invisible impressions that need to be developed before being used for criminal investigation; however, existing fingerprint visualization techniques face challenges, such as complex preparation and poor contrast. To advance practical fingerprint detection, green-emissive micron-sized curcumin/kaolin composites were synthesized a facile and cost-effective one-step physical cross-linking method, which exhibited unprecedented performance in developing diversified marks, including LFPs, knuckle prints, palm prints, and footprints, with clear three-level details on various substrates. Notably, the powders successfully developed LFPs that were aged for 30 days and even up to 100 days, meeting the stringent requirements for comprehensive forensic application.

Clinical Manifestations.

Background: Subjective Cognitive Decline (SCD) may represent the initial symptom of Alzheimer's disease (AD), but SCD may be absent and/or unrelated to actual cognitive decline. Objective Subtle Cognitive Decline (obj-SCD) can be identified through longitudinal standardized neuropsychological tests in individuals not yet meeting criteria for Mild Cognitive Impairment (MCI). We argue that the relationship between SCD and obj-SCD might help to inform clinical and research criteria in pre-MCI stages.

Clinical Manifestations.

Background: Accumulating evidence has shown the neuroprotective effects of estrogen on cognition function, for example delaying the cognitive deterioration in patients with Alzheimer's disease (AD). However, the clinical usage of estrogen in AD remains controversial. The cytochrome P450 aromatase encoded by CYP19A1, is a key enzyme catalyzing the C19 androgen conversion to C18 estrogen, which induces testosterone to estradiol and androstenedione to estrone.

Clinical Manifestations.

Background: Objective Subtle Cognitive Decline (obj-SCD) can be identified through standardized neuropsychological tests and may precede the development of Mild Cognitive Impairment (MCI). Nevertheless, current clinical and research criteria lack a standardized protocol for identifying obj-SCD. This study introduces cutting-edge sensitive methods to characterize obj-SCD, defined through Alzheimer's disease (AD) biomarker-based longitudinal cognitive performance in episodic memory.

Polymorphic Crystalline Layer at the Crystallization Front.

The morphology and kinetics of the crystal growth front have been poorly explored at the particle level. Here, we experimentally observe the crystal growth front in liquid with single-particle kinetics using colloid systems and reveal a surface layer of polymorphic crystal near the solid-solid transition when the two crystals form a low-energy coherent interface. The thickness of the surface crystal can exceed 50 particles and grows logarithmically with the temperature as approaching the solid-solid transition which follows premelting theory.

Chiral Phonons Induced from Spin Dynamics via Magnetoelastic Anisotropy.

We propose a mechanism to obtain chiral phononlike excitations from the bond-dependent magnetoelastic couplings in the absence of out-of-plane magnetization and magnetic fields. By mapping the hybrid excitation to its phononic analog, we reveal the impact of the lattice symmetry on the origin of the chirality. In the example of a triangular lattice ferromagnet, we recognize that the system is equivalent to the class D of topological phonons, and show the tunable chirality and topology by an in-plane magnetic field.

Clinical Manifestations.

Background: Clinically meaningful cognitive impairment has typically been defined as a single impaired test score, but this approach is prone to false-positive errors. Examining two test scores at a lower threshold (i.e.

Clinical Manifestations.

Background: The Hong Kong Brief Cognitive Test (HKBC) has solved the problems of limited population, insufficient coverage of cognitive domains and copyright limitation of previously used cognitive function test tools, which has a preliminary research basis for promotion. To make HKBC more widely used, it is necessary to collect normative data from different regions to make it have reference standards.

Method: From September 2019 to December 2021, 2312 aged 40 years and older people were recruited from different regions of China as norm construction participants.

Clinical Manifestations.

Background: Each year, millions of Americans experience mild traumatic brain injury (mTBI). Current research on the long-term effects of mTBI vary considerably. Several mechanisms linking mTBI to dementia have been proposed including amyloid plaque formation and cerebrovascular injury following mTBI.

Global, regional, and national burden of primary liver cancer attributable to metabolic risks: an analysis of the Global Burden of Disease Study 1990-2021.

Background: The global burden of metabolic diseases is increasing, but estimates of their impact on primary liver cancer are uncertain. We aimed to assess the global burden of primary liver cancer attributable to metabolic risk factors, including high body mass index (BMI) and high fasting plasma glucose (FPG) levels, between 1990 and 2021.

Methods: The total number and age-standardized rates of deaths and disability-adjusted life years (DALYs) from primary liver cancer attributable to each metabolic risk factor were extracted from the Global Burden of Disease Study 1990-2021.

Family Caregivers' Experiences of Long-Term Care Residents Living With Dementia During the COVID-19 Pandemic: An International Grounded Theory Study.

Aims: Caution around the COVID-19 pandemic resulted in visitation restrictions to prevent the spread of the virus among vulnerable older persons living in long-term care (LTC), which posed a threat to individual well-being and family togetherness across the globe. The purpose of this study was to explore family caregiver's experience of having a person who is living with dementia residing in a long-term care facility during the COVID-19 pandemic.

Design: Qualitative descriptive study using constructivist grounded theory (GT) methodology.

Non-Pharmacological Interventions Targeting Sense of Coherence Among Older Adults and Adults With Chronic Conditions: A Meta-Analysis With Trial Sequential Analysis.

Background: Sense of coherence (SoC) is a core concept of 'salutogenesis' in positive psychology, correlated with emotional distress and disease development in adults with chronic disease and older adults. A diversity of non-pharmacological interventions (NPIs) has been developed to enhance SoC, but research findings are conflicting and the adequacy of sample sizes is uncertainty.

Objective: This paper aimed to explore appropriate interventions, evaluate the effectiveness of these SoC interventions and verify the statistical robustness and reliability of pooled results.

Who Can Help Me? Citizens' Help-Seeking on Weibo During the Shanghai Lockdown.

Objective: In the context of the Omicron-induced lockdown in Shanghai, this paper investigated the appeals for assistance by citizens on Weibo, aiming to understand their principal challenges and immediate needs.

Methods: This paper collected Weibo posts ( 1040) containing the keyword "Shanghai Anti-epidemic Help" during the citywide lockdown. The online help requests from Shanghai citizens were analyzed across 7 dimensions, including the help sought, level of urgency, help recipient, the intended beneficiary of the help, expression, position, and emotion.

Longitudinal Associations Between Youth Information Management With Mothers and Self-Esteem: The Role of a Sense of Control.

Introduction: Adolescents' information management behaviors involve calibrating interactions between the self and parents, which could serve as either risk or protective factors for self-esteem. Since a sense of control over life outcomes is a protective factor for overall well-being, it might account for links between youth information management and self-esteem. This longitudinal study examined whether youth's sense of control mediated associations between concealment and voluntary disclosure and their self-esteem, at both the between- and within-person levels.