The Digital Health Competencies in Medical Education Framework: An International Consensus Statement Based on a Delphi Study.

Importance: Rapid digitalization of health care and a dearth of digital health education for medical students and junior physicians worldwide means there is an imperative for more training in this dynamic and evolving field.

Objective: To develop an evidence-informed, consensus-guided, adaptable digital health competencies framework for the design and development of digital health curricula in medical institutions globally.

Evidence Review: A core group was assembled to oversee the development of the Digital Health Competencies in Medical Education (DECODE) framework.

Better objective sleep quality is associated with higher gut microbiota richness in older adults.

Aging is associated with disrupted sleep patterns, such as fragmented sleep and reduced efficiency, leading to negative health outcomes. There is evidence of a bidirectional relationship between sleep and gut microbiota, which plays a key role in the gut-brain axis and overall health. However, studies on this relationship in older adults have limited generalizability and show conflicting results, highlighting the need for further research.

Trends in insecticide resistance in natural populations of Culex quinquefasciatus and its impact on mosquito fitness in Dschang, West Cameroon.

Specific information about the dispersion of Culex quinquefasciatus from Dschang in western Cameroon is scarce, and evidence-based interventions are needed. Common use of larvicides and adulticides conduct to the development of vectors resistance which can lead to deep biological changes, including fitness costs. We assessed the profile of insecticide resistance in field populations of Cx.

Long-term effects of superselective renal artery embolization on renal function after percutaneous nephrolithotomy.

Objectives: To investigate the long-term impact of superselective renal artery embolization (SRAE) on renal function in cases of severe post-percutaneous nephrolithotomy (PCNL) haemorrhage, and to identify the factors associated with the long-term outcome of renal function.

Methods: Patients treated with SRAE for post-PCNL hemorrhage between September 2016 and September 2021 were included. Patients' demographic and clinical data were recorded.

CD47 Knock-Out Using CRISPR-Cas9 RNA Lipid Nanocarriers Results in Reduced Mesenchymal Glioblastoma Growth In Vivo.

Immune checkpoint (ICP) blockade has shown limited effectiveness in glioblastoma (GBM), particularly in the mesenchymal subtype, where interactions between immune cells and glioblastoma cancer stem cells (GSCs) drive immunosuppression and therapy resistance. Tailoring ICPs specific to GSCs can enhance the antitumor immune response. This study proposes the use of lipid nanoparticles (LNPs) encapsulating CRISPR RNAs as an in vivo screening tool for ICPs in a syngeneic model of mesenchymal GSCs.

Peptide-Bound Aflibercept Eye Drops for Treatment of Neovascular Age-Related Macular Degeneration in Nonhuman Primates.

The advent of biomacromolecules antagonizing vascular endothelial growth factor (VEGF) has revolutionized the treatment of neovascular age-related macular degeneration (nAMD). However, frequent intravitreal injections of these biomacromolecules impose an enormous burden on patients and create a massive workload for healthcare providers. This causes patients to abandon therapy, ultimately leading to progressive and irreversible vision loss.

Lewis and Brønsted Acids Synergy in Photocatalytic Aerobic Alcohol Oxidations.

Photocatalytic chemical transformations for green organic synthesis has attracted much interest. However, their development is greatly hampered by the lack of sufficient reactive sites on the photocatalyst surface for the adsorption and activation of substrate molecules. Herein, we demonstrate that the introduction of well-defined Lewis and Brønsted acid sites coexisting on the surface of TiO2 (SO42-/N-TiO2) creates abundant active adsorption sites for photoredox reactions.

Predictive Value of Preoperative Nutritional Risk Index for Screw Loosening After Lumbar Interbody Fusion in Elderly Patients With Lumbar Spine Diseases.

Objective: Pedicle screw loosening is one of the common complications in elderly patients undergoing transforaminal lumbar interbody fusion (TLIF) for lumbar spine disease. Malnutrition, prevalent among elderly patients, has been shown to be associated with increased complications. The Geriatric Nutritional Risk Index (GNRI) serves as a simple indicator of nutritional status.

APAGE Position Statements on Green and Sustainability in Gastroenterology, Hepatology, and Gastrointestinal Endoscopy.

Background And Aim: The APAGE Position Statements aimed to provide guidance to healthcare practitioners on clinical practices aligned with climate sustainability.

Methods: A taskforce convened by APAGE proposed provisional statements. Twenty-two gastroenterologists from the Asian Pacific region participated in online voting and consensus was assessed through an anonymized and iterative Delphi process.

Tissue Mimetic Membranes for Healing Augmentation of Tendon-Bone Interface in Rotator Cuff Repair.

The globally prevalent rotator cuff tear has a high re-rupture rate, attributing to the failure to reproduce the interfacial fibrocartilaginous enthesis. Herein, a hierarchically organized membrane is developed that mimics the heterogeneous anatomy and properties of the natural enthesis and finely facilitates the reconstruction of tendon-bone interface. A biphasic membrane consisting of a microporous layer and a mineralized fibrous layer is constructed through the non-solvent induced phase separation (NIPS) strategy followed by a co-axial electrospinning procedure.

Defective Cystic Fibrosis Transmembrane Conductance Regulator Accelerates Skeletal Muscle Aging by Impairing Autophagy/Myogenesis.

Background: Regenerative capacity of skeletal muscles decreases with age. Deficiency in cystic fibrosis transmembrane conductance regulator (CFTR) is associated with skeletal muscle weakness as well as epithelial cell senescence. However, whether and how CFTR plays a role in skeletal muscle regeneration and aging were unclear.

Design, Synthesis and Application of Chiral Spirocyclic Bisindoles.

While modifications of the privileged catalyst backbones, such as 1,1'-spirobiindane-7,7'-diol (SPINOL), have led to the development of diverse useful chiral catalysts, the incorporation of heteroarenes in such chiral spirocyclic structures has limitedly known. Herein we report the design of a type of chiral spirocyclic bisindole skeletons where the electronically distinct heteroarenes serve as direct anchor for functional sites. Separate approaches for the synthesis of two different families of such skeletons have been developed via chiral phosphoric acid and rhodium catalysis, respectively.

Cranial bone maneuver ameliorates Alzheimer's disease pathology via enhancing meningeal lymphatic drainage function.

Introduction: Alzheimer's disease (AD) is a progressive neurodegenerative disease and the leading cause of dementia. Recent research highlights meningeal lymphatics as key regulators in neurological diseases, suggesting that enhancing their drainage function could be a potential therapeutic strategy for AD. Our proof-of-concept study demonstrated that cranial bone transport can improve meningeal lymphatic drainage function and promote ischemic stroke recovery.

The Critical Role of Atomic-Scale Polarization in Transition Metal Oxides on Vanadium-Redox Electrochemistry.

Transition metal oxide electrocatalysts (TMOEs) are poised to revive grid-scale all-vanadium redox flow batteries (VRFBs) due to their low-cost and unique electronic properties, while often inescapably harboring surface vacancies. The role of local vacancy-induced physicochemical properties on vanadium-redox electrochemistry (VRE), encompassing kinetics, and stability, remains profoundly unveiled. Herein, for the first time, it is revealed that vacancies induce atomic-scale polarization in TMOEs and elucidate its mechanism in VRE.

Simultaneous Isotropic Omnidirectional Hypersensitive Strain Sensing and Deep Learning-Assisted Direction Recognition in a Biomimetic Stretchable Device.

Omnidirectional strain sensing and direction recognition ability are features of the human tactile sense, essential to address the intricate and dynamic requirements of real-world applications. Most of the current strain sensors work by converting uniaxial strain into electrical signals, which restricts their use in environments with multiaxial strain. Here, the first device with simultaneous isotropic omnidirectional hypersensitive strain sensing and direction recognition (IOHSDR) capabilities is introduced.

MXene-Based Flexible Memory and Neuromorphic Devices.

As the age of the Internet of Things (IoTs) unfolds, along with the rapid advancement of artificial intelligence (AI), traditional von Neumann-based computing systems encounter significant challenges in handling vast amounts of data storage and processing. Bioinspired neuromorphic computing strategies offer a promising solution, characterized by features of in-memory computing, massively parallel processing, and event-driven operations. Compared to traditional rigid silicon-based devices, flexible neuromorphic devices are lightweight, thin, and highly stretchable, garnering considerable attention.

Single-Cell Landscape of Bronchoalveolar Lavage Fluid Identifies Specific Neutrophils during Septic Immunosuppression.

Sepsis-induced immunosuppression is related to increased susceptibility to secondary infections and death. Lung is the most vulnerable target organ in sepsis, but the understanding of the pulmonary immunosuppression state is still limited. Here, single-cell RNA sequencing of bronchoalveolar lavage fluid (BALF) is performed to map the landscape of immune cells, revealing a neutrophil-driven immunosuppressive program in the lungs of patients with immunosuppressive sepsis.

Efficient Spin-Light-Emitting Diodes With Tunable Red to Near-Infrared Emission at Room Temperature.

Spin light-emitting diodes (spin-LEDs) are important for spin-based electronic circuits as they convert the carrier spin information to optical polarization. Recently, chiral-induced spin selectivity (CISS) has emerged as a new paradigm to enable spin-LED as it does not require any magnetic components and operates at room temperature. However, CISS-enabled spin-LED with tunable wavelengths ranging from red to near-infrared (NIR) has yet to be demonstrated.

Facing the "Cutting Edge:" Edge Site Engineering on 2D Materials for Electrocatalysis and Photocatalysis.

The utilization of 2D materials as catalysts has garnered significant attention in recent years, primarily due to their exceptional features including high surface area, abundant exposed active sites, and tunable physicochemical properties. The unique geometry of 2D materials imparts them with versatile active sites for catalysis, including basal plane, interlayer, defect, and edge sites. Among these, edge sites hold particular significance as they not only enable the activation of inert 2D catalysts but also serve as platforms for engineering active sites to achieve enhanced catalytic performance.

Endoscopic sleeve gastroplasty - Current status and future perspectives.

Obesity is a worldwide epidemic and present significant health-care burdens for individuals and health-care systems. Bariatric endoscopy is an evolving field known for benefits including being minimally invasive, reversible, and organ preserving, providing a promising alternative to traditional bariatric surgery. Various endoscopic procedures targeting on the stomach and small bowel have been developed.

Complete Breakup of Liquids into Ultrafine Droplets by Grid Turbulence.

Ultrafine droplets are crucial in materials processing and nanotechnology, with applications in nanoparticle preparation, water evaporation, nanodrug delivery, nanocoating, among numerous others. While the potential of turbulent gas flow to enhance liquid breakup is acknowledged, constructing turbulence-driven atomizers for ultrafine droplets remains challenging. Herein, we report the innovation of grid-turbulence atomization (GTA), which employs a rotating mesh to deliver liquid and an air knife to spray ultrafine droplets.

Clinical applications and research progress of totally implantable venous access ports: a literature review.

Totally implantable venous access port (TIVAP), a novel intravenous infusion system that is used for long-term intravenous treatment, has become increasingly popular among cancer patients undergoing chemotherapy and other patients requiring long-term intravenous infusions. This technology has been introduced into clinical practice in China, with successful results. Nevertheless, there are still certain problems; for instance, China has not set up a specialized regulatory agency to oversee research and set guidelines for the comprehensive life-cycle management of TIVAP.