Current Paradigm and Future Directions in the Management of Nodal Disease in Locally Advanced Cervical Cancer.

Approximately 36% of patients with cervical cancer present with regional nodal metastasis at diagnosis, which is associated with adverse survival outcomes after definitive treatment. In the modern era of chemoradiotherapy (CRT) and image-guided adaptive brachytherapy (IGABT), where excellent local control is achieved for patients with locally advanced cervical cancer (LACC), nodal failure remains a major challenge to cure. To optimize treatment outcomes for node-positive LACC and reduce the incidence of nodal failure, various treatment approaches have been explored, including methods of surgical nodal staging or dissection, RT dose escalation strategies, such as intensity-modulated radiotherapy (IMRT) with simultaneous integrated boost (SIB) to involved nodes, and elective treatment of subclinical para-aortic (PAO) disease.

Comparative Analysis of One Health Policies in Asia for Exploring Opportunities for British Columbia in Canada.

In response to emerging challenges that intersect humans, animals, and environments, there is growing international exigent need to adopt 'One Health' approaches. While One Health efforts are emerging in British Columbia in Canada, there are still challenges to overcome in the adoption of a One Health approach in policymaking. We conducted a comparative analysis of One Health policies in Asia, specifically, Singapore, Hong Kong, Bangladesh, and Thailand, which have well-established and sophisticated One Health approaches, to determine good practices in the implementation of One Health that could be considered for adoption in British Columbia.

Beclin 1-Mediated Autophagy Is Potentiated by an Interaction with the Neuronal Adaptor FE65.

Autophagy is a vital cellular pathway in eukaryotic cells, including neurons, where it plays significant roles in neurodevelopment and maintenance. A crucial step in autophagy is the formation of the class III phosphatidylinositol 3-kinase complex 1 (PI3KC3-C1), which is essential for initiating autophagosome biogenesis. Beclin 1 is the key component of PI3KC3-C1, and its interactors have been reported to affect autophagy.

GRAMMAR-Lambda Delivers Efficient Understanding of the Genetic Basis for Head Size in Catfish.

The shape of the skull plays a crucial role in the evolution and adaptation of species to their environments. In the case of aquaculture fish, the size of the head is also an important economic trait, as it is linked to fillet yield and ornamental value. This study applies our GRAMMAR-Lambda method to perform a genome-wide association study analysis on loci related to head size in catfish.

Psychometric Validation of the Simplified Chinese Version of the Dyspnoea-12 Questionnaire for Patients with Primary Lung Cancer.

The simplified Chinese version of the Dyspnoea-12 Questionnaire (D-12) has not yet been translated and validated for patients with primary lung cancer. This study aimed to evaluate the psychometric properties of the simplified Chinese version of the D-12 for patients with primary lung cancer. This study analysed the baseline data of a randomised controlled trial that used an inspiratory muscle training intervention for patients with thoracic malignancies.

Development and Validation of Child Observation Checklist for Early Screening of Young Children with Special Needs.

Families with young children with developmental disabilities often express concerns about delays in the identification of these and extended waiting times for obtaining assessments, learning support, and rehabilitation services. The identification process must and can be enhanced if preschool teachers have instrumental measures to detect early-stage developmental disabilities and adjustment difficulties in preschool children and, if necessary, to provide these children with prompt and effective support services. The aim with this study was to develop and validate a screening checklist for teachers to detect developmental delays and adjustment difficulties in Chinese preschool children in Hong Kong.

Intergenerational Transaction of Emotional Health in Collective Family Context: Family Functioning, Parental and Children's Gratitude, and Their Depression.

The current study is intended to examine how positive family functioning, collectively constructed by parents and children in the family context, may contribute to their gratitude and depression, two pivotal human emotions closely related to human health, in which the gratitude and depression of parents and children are assumed to affect each other bidirectionally and parental and children's gratitude is expected to link the relations between positive family functioning and their depression. The data for analysis came from a community sample of 310 Chinese parent-child dyads, which were measured by the Family Functioning Style Scale (FFSS), Gratitude Questionnaire (GQ), and depression subscale of the Brief Symptom Inventory (BSI) from both the parent and child participants. : The results indicated that positive family functioning contributed to higher parental and children's gratitude and their less depression, and parental and children's gratitude and depression affected each other positively.

The Moderating Role of Social Capital Between Parenting Stress and Mental Health and Well-Being Among Working Mothers in China.

Unlabelled: Rapid economic growth has transformed social and family structure globally, including in China, over the past few decades. With women's engagement in the workforce, the dual demand of paid and domestic work has become a major source of stress, particularly among mothers. Working mothers face unique challenges of family obligations blended with contemporary values of women's career aspirations.

Current Updates on Molecular Diagnostic Assays Used for Detection of : A Systematic Review.

: is an emerging multidrug-resistant pathogen with the potential to cause invasive fungal infections and healthcare-associated outbreaks. Currently, there is no systematic review explicitly focusing on the up-to-date molecular diagnostics of this pathogen to cover the entire process, including sample pre-extraction procedures, nucleic acid extraction, and DNA-based detection. Sample pre-treatment and extraction are the prerequisites before molecular testing and have implications on the downstream detection but have not been reviewed elsewhere.

An Overview of the Current Scientific Evidence on the Biological Properties of (L.) Moench (Okra).

(L.) Moench, commonly known as okra or lady's finger, is an annual flowering plant belonging to the family. Okra is a native plant in Africa as well as a traditional medicine in Africa and India for treating different diseases and conditions.

The association of lifestyle with cardiovascular and all-cause mortality based on machine learning: a prospective study from the NHANES.

Background: Lifestyle and cardiovascular mortality and all-cause mortality have been exhaustively explored by traditional methods, but the advantages of machine learning (ML) over traditional methods may lead to different or more precise conclusions. The aim of this study was to evaluate the effectiveness of machine learning-based lifestyle factors in predicting cardiovascular and all-cause mortality and compare the results obtained by traditional methods.

Method: A prospective cohort study was conducted using a nationally representative sample of adults aged 40 years or older, drawn from the US National Health and Nutrition Examination Survey from 2007 to 2010.

Ten pressure points in primary care during COVID-19: findings from an international narrative review.

Background: Strong primary care (PC) services are the foundation of high-performing health care systems and can support effective responses to public health emergencies. Primary care practitioners (PCPs) and PC services played crucial roles in supporting global health system responses to the COVID-19 pandemic. However, these contributions have come at a cost, impacting on PC services and affecting patient care.

The impact of drinking on smoking cessation outcomes among Hong Kong Chinese youth smokers.

Drinking is a common unhealthy behaviour among youth smokers aged 25 or below. However, the effects of drinking on smoking cessation outcomes are not well understood. This study aimed to explore the impact of drinking on smoking cessation outcomes among Hong Kong Chinese youth smokers who received smoking cessation counselling.

Design of asymmetric electrolytes for aqueous zinc batteries.

Aqueous Zn batteries are gaining increasing research attention in the energy storage area due to their intrinsic safety, potentially low cost and environmental friendliness; however, the zinc dendrite formation, zinc corrosion, passivation and the hydrogen evolution reaction induced by water at the anode side, and materials dissolution as well as intrinsic poor reaction kinetics at cathode side in aqueous systems, seriously shorten the cycling life and decrease energy density of batteries and greatly hinder their development. Recent advancements in asymmetric electrolytes with various functions are promising to overcome such challenges for zinc batteries at the same time. It has been proved that the applications of asymmetric electrolytes show significant contributions in the field of zinc-based batteries in suppressing side reactions while maintaining electrochemical performance to satisfy both anode and cathode.

Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe through TRPML1 channel.

Lysosomes are best known for their roles in inflammatory responses by engaging in autophagy to remove inflammasomes. Here, we describe an unrecognized role for the lysosome, showing that it finely controls macrophage inflammatory function by manipulating the lysosomal Fe-prolyl hydroxylase domain enzymes (PHDs)-NF-κB-interleukin 1 beta (IL1B) transcription pathway that directly links lysosomes with inflammatory responses. TRPML1, a lysosomal cationic channel, is activated secondarily to ROS elevation upon inflammatory stimuli, which in turn suppresses IL1B transcription, thus limiting the excessive production of IL-1β in macrophages.

Occurrence of Leishmania spp. in phlebotomine sand flies and dogs in Guelma region, North-eastern Algeria.

Leishmania spp. are sand fly-borne parasitic protozoa of worldwide distribution that may severely affect the health and welfare of dogs as well as of other mammalian species, including humans. Algeria is among the most affected countries, counting several cases of Leishmania infantum infection in humans and dogs.

Child exposure to N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its derived quinone (6PPDQ) in e-waste areas: Urinary concentrations, sources, and health effect assessment.

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPDQ) and its parent 6PPD are ubiquitous in the environment and may induce multi-endpoint toxicity. Electronic waste (e-waste) dismantling is an under-recognized source of 6PPD and 6PPDQ emissions, and there is a lack of epidemiological investigations into their presence and health effects in local populations. This study aimed to determine the urinary concentrations of 6PPD and 6PPDQ in children aged 2-7 years from e-waste dismantling areas and evaluate their potential risk to physical growth.

Oral microbiota among treatment-naïve adolescents with depression: A case-control study.

Background: Adolescent depression has profound impacts on physical, cognitive, and emotional development. While gut microbiota changes have been linked to depression, the relationship between oral microbiota and depression remains elusive. Our study aims to investigate the oral microbiota in treatment-naïve adolescents experiencing depression and examine their potential associations with cognitive function.

A retrospective analysis of 338 surgically treated pituitary adenomas.

Objective: To summarize the clinical characteristics, pituitary function assessment, postoperative pathological features, and postoperative recurrence of surgically treated pituitary adenomas (PAs).

Methods: We retrospectively reviewed the data of 338 patients (169 women; average age: 50.01 ± 12.

Transcranial Direct Current Stimulation Improves Paranoia and Social Functioning in Schizophrenia: A Randomized Clinical Trial.

Background: Innovative treatments for paranoia, which significantly impairs social functioning in schizophrenia (SCZ), are urgently needed. The pathophysiology of paranoia implicates the amygdala-prefrontal (PFC) circuits; thus, this study systematically investigated whether transcranial direct current stimulation (tDCS) to the ventrolateral PFC can attenuate paranoia and improve social functioning in SCZ.

Methods: A double-blind, within-subjects, crossover design was used to compare active vs.

The effects of volunteering on loneliness among lonely older adults: the HEAL-HOA dual randomised controlled trial.

Background: Previous randomised controlled trials have largely relied on self-reported volunteer work to assess the effects of volunteering and have rarely provided structured volunteering activities during the intervention period. The present study aimed to investigate the effects of social volunteering work over 12 months on loneliness among older adults during the COVID-19 pandemic.

Methods: A dual randomised controlled trial was done in Hong Kong to investigate the long-term effects of telephone-delivered psychosocial interventions by older Chinese volunteers who were screened as lonely, for older adult recipients who had low income, lived alone, felt lonely, and were digitally excluded.

Difference in movement coordination and variability during Five-Repetition Sit-to-Stand between people with and without Chronic Low back pain.

Chronic low back pain (CLBP) affects people's activities of daily living, including sitting down and standing up. Movement pattern analyses during five-repetition sit-to-stand (5RSTS) may allow CLBP status differentiation. 44 CLBP and 22 asymptomatic participants performed 5RSTS in this study, with their trunk and lower limb movements recorded using 3-dimensional motion capture system.

Examining maternal social perceptions and stress responses during pregnancy.

Pregnant women are sensitive to the emotions and cues present in social interactions. They may exhibit heightened stress responses when support is lacking in a harmonious environment. The objective of this study was to examine the interaction of family harmony and social support and its association with stress responses among pregnant women.

Effects of ketogenic and low-carbohydrate diets on the body composition of adults with overweight or obesity: A systematic review and meta-analysis of randomised controlled trials.

Background And Aims: More than one-third of individuals are overweight and obese in the world. Their risks of chronic health conditions are increased, which places additional burden on their family, caregivers, and healthcare system. Dietary modification is widely used for overweight and obese individuals.