22 results match your criteria: "Honam Regional Center for Disease Control and Prevention[Affiliation]"

Comparative safety of monovalent and bivalent mRNA COVID-19 booster vaccines in adolescents aged 12 to 17 years in the Republic of Korea.

Osong Public Health Res Perspect

August 2024

Bureau of Public Health Emergency Preparedness, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea.

Background: This study analyzed the safety of coronavirus disease 2019 (COVID-19) bivalent and monovalent booster vaccines, including the frequency of adverse events (AEs) such as myocarditis and pericarditis, in adolescents aged 12 to 17 years in the Republic of Korea. We aimed to share the safety profile of the COVID-19 bivalent vaccine booster doses.

Methods: We analyzed the frequencies of AEs reported to the COVID-19 vaccination management system (CVMS) or self-reported through the text message survey (TMS).

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Background: This study analyzed a large outbreak of coronavirus disease 2019 (COVID-19) that occurred during a high school field trip in the Jeonbuk region and aimed to identify risk factors for COVID-19 infection, with the goal of preventing such outbreaks in the future.

Methods: A retrospective cohort study of 737 participants, including 668 students and 69 staff at High School A, was designed to describe the epidemiological characteristics of this large COVID-19 outbreak. Logistic regression analysis was performed to calculate relative risks (odds ratios [ORs]) and 95% confidence intervals (CIs).

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Background: Despite the high vaccination coverage rate, in-hospital transmission of measles continues to occur in South Korea. We present a measles outbreak in which two healthcare workers (HCWs) with presumptive evidence of measles immunity were infected by a patient with typical measles at a single hospital in South Korea. This facilitated the evaluation of measles seroprevalence in all HCWs.

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Risk factors for transmission in a COVID-19 cluster infection in a high school in the Republic of Korea.

Osong Public Health Res Perspect

August 2023

Division of Epidemiological Investigation Analysis, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea.

Background: This study aimed to examine the scale, characteristics, risk factors, and modes of transmission in a coronavirus disease 2019 (COVID-19) outbreak at a high school in Seoul, Republic of Korea.

Methods: An epidemiological survey was conducted of 1,118 confirmed cases and close contacts from a COVID-19 outbreak at an educational facility starting on May 31, 2021. In-depth interviews, online questionnaires, flow evaluations, and CCTV analyses were used to devise infection prevention measures.

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Article Synopsis
  • The study investigates SARS-CoV-2 variants on Jeju Island, South Korea, from February 2021 to September 2022, utilizing genomic surveillance to track changes.
  • The dominant Alpha variant was replaced by Delta in July 2021, with Omicron becoming prevalent by December 2021, showcasing the rapid evolution of the virus.
  • Findings highlight key spike protein mutations (N440K and G446S) linked to immune evasion, emphasizing the importance of monitoring variants to manage the pandemic effectively.*
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Effectiveness of the COVID-19 vaccine in the Honam region of the Republic of Korea.

Osong Public Health Res Perspect

June 2023

Division of Infectious Disease Diagnosis Control, Honam Regional Center for Disease Control and Prevention, Korea Diseases Control and Prevention Agency, Gwangju, Republic of Korea.

Article Synopsis
  • A study conducted in 2021 in the Honam region of South Korea assessed the effectiveness of COVID-19 vaccines and monitored changes in dominant virus strains.
  • Results showed a high vaccination rate of 88.6%, with overall vaccine effectiveness at 98.7% and a breakthrough infection rate of just 0.16%.
  • The emergence of new variants like Delta and Omicron impacted vaccine effectiveness over time, but receiving booster doses helped restore antibody levels, ensuring continued protection.
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Article Synopsis
  • - The study analyzed the prevalence of depression among Koreans in urban versus rural areas, with data from over 216,000 participants using the PHQ-9 scale for assessment.
  • - Results showed a higher prevalence of depressive symptoms in urban areas (3.33%) compared to rural areas (2.59%), particularly among those with lower income levels.
  • - The findings indicate significant urban-rural disparities in mental health, highlighting the need for tailored mental health policies that address these differences based on residence and socioeconomic status.
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A Seroprevalence Study on Residents in a Senior Care Facility with Breakthrough SARS-CoV-2 Omicron Infection.

Viral Immunol

April 2023

Division of Emerging Infectious Diseases, Bureau of Infectious Diseases Diagnosis Control, Korea Disease Control and Prevention Agency (KDCA), Cheongju-si, Republic of Korea.

The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began spreading rapidly in the community in November 2021, becoming the dominant variant in the Republic of Korea in 2022. Although its pathogenesis in healthy individuals was low, the severity and hospitalization rate was higher in the elderly and immunocompromised patients. We aimed to investigate the immunogenicity in acute and convalescent phases of breakthrough infection by Omicron in elderly individuals.

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Pseudoknot-targeting Cas13b combats SARS-CoV-2 infection by suppressing viral replication.

Mol Ther

June 2023

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea; KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea. Electronic address:

Article Synopsis
  • CRISPR-Cas13 technology is being used to target specific regions of the SARS-CoV-2 virus's genome to help combat its spread and variants.
  • Researchers developed Cas13b molecules that focus on the ORF1b region, particularly targeting a pseudoknot site, which effectively shuts down the virus's ability to replicate.
  • In experiments with mice, using these treatments significantly lowered viral levels, indicating that targeting the pseudoknot may be a promising approach for treating COVID-19 and other RNA viruses.
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Viral detection from negative mumps cases with respiratory symptoms in Gwangju, South Korea in 2021.

J Med Virol

March 2023

Division of Infectious Disease Diagnosis Control, Honam Regional Center for Disease Control and Prevention, Korea Diseases Control and Prevention Agency, Gwangju, South Korea.

Mumps is the second-most reported infectious disease in South Korea; however, due to the low pathogen confirmation rate in laboratory diagnoses, we proposed a method for reevaluating the high incidence rate via the laboratory verification of other viral diseases. In 2021, 63 cases of pharyngeal or cheek mucosal swabs of suspected mumps cases in Gwangju, South Korea, were assessed for causative pathogens using massive simultaneous pathogen testing. More than one respiratory virus was detected in 60 cases (95.

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To investigate viruses in measles-negative cases, 221 measles-suspected samples collected in Gyeonggi Province, South Korea were tested using a real-time PCR assay. Rubella virus was not detected. However, 11 cases of parvovirus B19 (5.

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Background: Determination of the release from isolation for coronavirus disease 2019 (COVID-19) in immunocompromised patients who need additional hospitalization for treatment of non-COVID-19 related disease is important to prevent nosocomial transmission. However, there is insufficient evidence for an extended isolation period.

Materials And Methods: In September 2021, when the Delta variant was dominant, a nosocomial outbreak of COVID-19 occurred in the nephrology ward of a tertiary hospital in Gwangju, Korea.

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Genetic Analysis of HPIV3 That Emerged during the SARS-CoV-2 Pandemic in Gwangju, South Korea.

Viruses

June 2022

Division of Infectious Disease Diagnosis Control, Honam Regional Center for Disease Control and Prevention, Korea Diseases Control and Prevention Agency, Gwangju 61947, Korea.

Article Synopsis
  • Community mitigation measures during the COVID-19 pandemic led to a decrease and delayed occurrence of respiratory viruses, including human parainfluenza virus type 3 (HPIV3) in Gwangju, Korea, with a peak outbreak observed in September-October 2021.
  • Genetic analyses of 129 HPIV3 strains from 2018 to 2021 revealed reduced diversity in 2021 compared to previous years, likely due to limited virus inflow from other regions as a result of mitigation efforts.
  • The 2021 HPIV3 strains showed significant genetic similarities to older sequences from Japan and India, highlighting the potential risk of a new lineage disrupting community immunity and emphasizing the need for ongoing viral monitoring.
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Most HIV-positive individuals diagnosed in Korea are infected through sexual contact, with the time of HIV infection therefore often being unknown. The aim of this study was to investigate the characteristics of diagnosed patients near the time of HIV seroconversion to establish useful HIV intervention strategies. Cross-sectional study.

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The number of coronavirus disease (COVID-19)-positive cases has increased in Jeju Island, Republic of Korea. Identification and monitoring of new mutations in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are extremely important to fighting the global pandemic. We report a breakout of the B.

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Measles susceptibility of marriage migrant women in Korea.

Epidemiol Health

May 2022

Jeonnam Communicable Disease Management Support Team, Muan, Korea.

International migrants could be considered a risk group susceptible to vaccine-preventable diseases. We conducted a measles seroprevalence study among 419 marriage migrant women living in Sinan-gun and Wando-gun, South Jeolla Province, located in the southwestern part of Korea. The overall seroimmunity was 92.

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SARS-CoV-2 Delta Variant Breakthrough Infection and Onward Secondary Transmission in Household.

J Korean Med Sci

January 2022

Epidemiological Investigation Team, Central Disease Control Headquarters, Korea Disease Control and Prevention Agency, Cheongju, Korea.

Background: Despite the extraordinary speed of mass vaccination efforts, an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delta variant in a vaccinee with coronavirus disease 2019 (COVID-19) mRNA vaccine was identified in an adult day service center (ADSC) of Jeju, South Korea. The primary objective of this study was to investigate the epidemiologic features in infection-vulnerable facilities with a high vaccination rate of BNT162b2 mRNA COVID-19 vaccine. The second was to estimate the secondary transmission prevention effect of the vaccine in the household members by vaccination status.

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Genetic Analysis of the Measles Virus From the Outbreaks in South Korea, 2019.

Front Microbiol

December 2021

Division of Infectious Disease Diagnosis Control, Honam Regional Center for Disease Control and Prevention, Korea Disease Control and Prevention Agency, Gwangju-si, South Korea.

Three genotypes (B3, D8, and H1) of the measles virus (MeV) have recently caused global outbreaks. In Korea, four measles outbreaks were reported during 2018-2019 and most patients were infants and health care workers in their 20s and 30s. To investigate the genetic characteristics and molecular epidemiology of the outbreaks, we analyzed the sequence of MeVs by targeting the N-450, MF-NCR, and/or H gene regions.

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Campylobacter fetus subspecies venerealis meningitis associated with a companion dog in a young adult: a case report.

BMC Infect Dis

December 2021

Department of Infectious Diseases, Ajou University School of Medicine, 164 Worldcup-ro, Youngtong-gu, Suwon, Gyeonggi-do, 16499, Republic of Korea.

Background: Campylobacter spp., common commensals in the gastrointestinal tract of animals, especially poultry, can cause acute gastrointestinal illness in humans through animal-to-human transmission. Although Campylobacter fetus, especially subspecies fetus, rarely leads to systemic infections such as bacteremia in immunocompromised patients, it is unclear whether Campylobacter fetus subspecies venerealis (Cfv) causes infectious diseases in humans.

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Article Synopsis
  • Safflower (L.) has historical uses in treating vascular issues related to the heart, brain, and diabetes, and this study explores its potential in reducing vascular inflammation in human cells.
  • The ethanol extract of safflower (ECT) was found to lower the adhesion of leukocytes and reduce key cell adhesion molecules, indicating a protective effect on blood vessel health.
  • ECT also decreases oxidative stress and suppresses harmful signaling pathways, suggesting it could be a promising natural treatment for vascular inflammation, but more research is needed to identify the most effective compounds.
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Article Synopsis
  • The study focused on individuals who re-tested positive for SARS-CoV-2 after recovering from their initial infection to assess the virus's infectivity.
  • Researchers analyzed 295 people with re-positive PCR results and their 836 close contacts, finding no viral presence in cell cultures from those with re-positive tests.
  • Out of the close contacts, three new cases of infection were identified, but all had prior infections, indicating that there was no evidence of targeted transmission from those with re-positive test results.
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The seasonal distribution of hard ticks was investigated in 2018 in Gyeongbuk Province, Republic of Korea. Ticks were assayed for severe fever with thrombocytopenia syndrome virus (SFTSV). Ticks were collected monthly using CO-baited traps from April to November in four habitats (grasslands, grave sites, hiking trails, and mixed forests).

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