125 results match your criteria: "Holst Centre[Affiliation]"
Micromachines (Basel)
November 2024
Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), 2333 BE Leiden, The Netherlands.
Background: To accurately measure permeability of compounds in the intestine, there is a need for preclinical in vitro models that accurately represent the specificity, integrity and complexity of the human small intestinal barrier. Intestine-on-chip systems hold considerable promise as testing platforms, but several characteristics still require optimization and further development.
Methods: An established intestine-on-chip model for tissue explants was adopted for intestinal cell monolayer culture.
PLOS Digit Health
December 2024
Department of Health Research, imec The Netherlands / Holst Centre, Eindhoven, The Netherlands.
Cardiovascular diseases are the leading cause of mortality and early assessment of carotid artery abnormalities with ultrasound is key for effective prevention. Obtaining the carotid diameter waveform is essential for hemodynamic parameter extraction. However, since it is not a trivial task to automate, compact computational models are needed to operate reliably in view of physiological variability.
View Article and Find Full Text PDFSensors (Basel)
November 2024
imec at Holst Centre, 5656 AE Eindhoven, The Netherlands.
A time-dependent electrochemical impedance spectroscopy (EIS) model is presented using the finite element method (FEM) to simulate a 2D interdigitated electrode in an aqueous NaCl electrolyte. Developed in COMSOL Multiphysics, the model incorporates ion transport, electric field distribution, Stern layer effects, and electrode sheet resistance, governed by the Poisson and Nernst-Planck equations. This model can predict the transient current response to an applied excitation voltage, which gives information about the dynamics of the electrochemical system.
View Article and Find Full Text PDFBioengineering (Basel)
October 2024
TNO, Holst Centre, High Tech Campus 31, 5656AE Eindhoven, The Netherlands.
The commercialization of a growing number of wearable devices has been enabled within recent years due to the availability of miniaturized sensor modalities, the development of new materials, and the scalability of flexible electronics. With the increase in resource shortages within healthcare, there is a demand to translate wearable devices from the commercial consumer stand-point to the medical field. Clinical-grade signal quality, wearability, and comfort all need to be tailored to a wearable design.
View Article and Find Full Text PDFERJ Open Res
November 2024
Pulmonology Department, Franciscus Gasthuis and Vlietland, Rotterdam, The Netherlands.
https://bit.ly/4cPnHUK.
View Article and Find Full Text PDFSci Rep
October 2024
Microbiology & Systems Biology, TNO (Netherlands Organisation for Applied Scientific Research), Leiden, The Netherlands.
Successful implementation of remote monitoring of vital signs outside of the hospital setting hinges on addressing three crucial unmet needs: longer-term wear, skin comfort and signal quality. Earlier, we developed a Health Patch research platform that uses self-adhesive dry electrodes to measure vital digital biomarkers. Here, we report on the analytical validation for heart rate, heart rate variability and respiration rate.
View Article and Find Full Text PDFSci Rep
May 2024
CERN - Occupational Health & Safety and Environmental Protection Unit, Radiation Protection Group, 1211, Geneva 23, Switzerland.
Hadron therapy is an advanced radiation modality for treating cancer, which currently uses protons and carbon ions. Hadrons allow for a highly conformal dose distribution to the tumour, minimising the detrimental side-effects due to radiation received by healthy tissues. Treatment with hadrons requires sub-millimetre spatial resolution and high dosimetric accuracy.
View Article and Find Full Text PDFFront Cell Infect Microbiol
April 2024
TNO, Holst Centre, Eindhoven, Netherlands.
Cutaneous diseases (such as atopic dermatitis, acne, psoriasis, alopecia and chronic wounds) rank as the fourth most prevalent human disease, affecting nearly one-third of the world's population. Skin diseases contribute to significant non-fatal disability globally, impacting individuals, partners, and society at large. Recent evidence suggests that specific microbes colonising our skin and its appendages are often overrepresented in disease.
View Article and Find Full Text PDFNat Commun
March 2024
Holst Centre, TNO, High Tech Campus 31, 5656 AE, Eindhoven, The Netherlands.
With the huge progress in micro-electronics and artificial intelligence, the ultrasound probe has become the bottleneck in further adoption of ultrasound beyond the clinical setting (e.g. home and monitoring applications).
View Article and Find Full Text PDFSensors (Basel)
March 2024
Limburg Clinical Research Center/Mobile Health Unit, Faculty of Biomedical and Life Sciences, Hasselt University, Agoralaan, 3590 Diepenbeek, Belgium.
Repeated single-point measurements of thoracic bioimpedance at a single (low) frequency are strongly related to fluid changes during hemodialysis. Extension to semi-continuous measurements may provide longitudinal details in the time pattern of the bioimpedance signal, and multi-frequency measurements may add in-depth information on the distribution between intra- and extracellular fluid. This study aimed to investigate the feasibility of semi-continuous multi-frequency thoracic bioimpedance measurements by a wearable device in hemodialysis patients.
View Article and Find Full Text PDFACS Appl Mater Interfaces
March 2024
Intel Corporation, Hillsboro, Oregon 97124-6497, United States.
Area-selective atomic layer deposition (AS-ALD) processes for TiO and TiON on SiN as the growth area vs SiO as the nongrowth area are demonstrated on patterns created by state-of-the-art 300 mm semiconductor wafer fabrication. The processes consist of an in situ CF/N plasma etching step that has the dual role of removing the SiN native oxide and passivating the SiO surface with fluorinated species, thus rendering the latter surface less reactive toward titanium tetrachloride (TiCl) precursor. Additionally, (dimethylamino)trimethylsilane was employed as a small molecule inhibitor (SMI) to further enhance the selectivity.
View Article and Find Full Text PDFSensors (Basel)
January 2024
Dätwyler Schweiz AG, 6467 Schattdorf, Switzerland.
In-ear acquisition of physiological signals, such as electromyography (EMG), electrooculography (EOG), electroencephalography (EEG), and electrocardiography (ECG), is a promising approach to mobile health (mHealth) due to its non-invasive and user-friendly nature. By providing a convenient and comfortable means of physiological signal monitoring, in-ear signal acquisition could potentially increase patient compliance and engagement with mHealth applications. The development of reliable and comfortable soft dry in-ear electrode systems could, therefore, have significant implications for both mHealth and human-machine interface (HMI) applications.
View Article and Find Full Text PDFJMIR Form Res
November 2023
Department of Cardiology, Máxima MC Eindhoven/Veldhoven, Veldhoven, Netherlands.
Background: Accurate detection of myocardial ischemia and arrhythmias during free-living exercise could play a pivotal role in screening and monitoring for the prevention of exercise-related cardiovascular events in high-risk populations. Although remote electrocardiogram (ECG) solutions are emerging rapidly, existing technology is neither designed nor validated for continuous use during vigorous exercise.
Objective: In this proof-of-concept study, we evaluated the usability, signal quality, and accuracy for arrhythmia detection of a single-lead ECG patch platform featuring self-adhesive dry electrode technology in individuals with chronic coronary syndrome.
Sensors (Basel)
October 2023
Magnel-Vandepitte Laboratory, Department of Structural Engineering and Building Materials, Ghent University, 9052 Ghent, Belgium.
Modern infrastructure heavily relies on robust concrete structures, underscoring the critical need for effective monitoring to ensure their safety and durability. This paper addresses this imperative issue by introducing an innovative automated and wireless system for continuous structural monitoring. By employing embedded electrical resistivity sensors coupled with a wireless-based data transmission mechanism, real-time data collection becomes feasible.
View Article and Find Full Text PDFSensors (Basel)
September 2023
Department of Information Technology, Ghent University/imec, B-9052 Ghent, Belgium.
This study investigates wireless power transfer for deep in-body receivers, determining the optimal frequency, power budget, and design for the transmitter and receiver. In particular, the focus is on small, in-body receivers at large depths up to 20 cm for obese patients. This enables long-term monitoring of the gastrointestinal tract for all body types.
View Article and Find Full Text PDFSensors (Basel)
August 2023
Magnel-Vandepitte Laboratory, Department of Structural Engineering and Building Materials, Faculty of Engineering and Architecture, Ghent University, Tech Lane Ghent Science Park, Campus A, Technologiepark Zwijnaarde 60, B-9052 Ghent, Belgium.
Concrete is a widely used construction material, demanding strict quality control to maintain its integrity. The durability and lifespan of concrete structures rely heavily, amongst other factors, on the characteristics of fresh and early age concrete, which are strongly dependent on the curing process. To ensure long-term durability, it is crucial to assess concrete properties throughout construction and verify compliance with design specifications.
View Article and Find Full Text PDFAcc Chem Res
August 2023
Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
ConspectusAtomically precise and highly selective surface reactions are required for advancing microelectronics fabrication. Advanced atomic processing approaches make use of small molecule inhibitors (SMI) to enable selectivity between growth and nongrowth surfaces. The selectivity between growth and nongrowth substrates is eventually lost for any known combinations, because of defects, new defect formation, and simply because of a Boltzmann distribution of molecular reactivities on surfaces.
View Article and Find Full Text PDFJMIR Res Protoc
July 2023
Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Background: Stress-related mental disorders are highly prevalent and pose a substantial burden on individuals and society. Improving strategies for the prevention and treatment of mental disorders requires a better understanding of their risk and resilience factors. This multicenter study aims to contribute to this endeavor by investigating psychological resilience in healthy but susceptible young adults over 9 months.
View Article and Find Full Text PDFClin Kidney J
June 2023
EKHA WG3, Brussels, Belgium.
Chronic kidney disease (CKD) is one of the fastest growing health problems, set to become the fifth global death cause by 2040. Factors contributing to this fast growth include increased survival from other diseases (cancer, cardiovascular disease, diabetes, etc.), population aging, lack of early CKD diagnosis tools, insufficient CKD awareness within healthcare systems, limited therapeutic armamentarium to prevent CKD progression and limitations of currently available kidney replacement therapies (KRTs).
View Article and Find Full Text PDFAdv Mater
June 2023
TNO-Holst Centre, High Tech Campus 31, Eindhoven, 6565 AE, The Netherlands.
A first-of-its-kind area-selective deposition process for SiO is developed consisting of film deposition with interleaved exposures to small molecule inhibitors (SMIs) and back-etch correction steps, within the same spatial atomic layer deposition (ALD) tool. The synergy of these aspects results in selective SiO deposition up to ~23 nm with high selectivity and throughput, with SiO growth area and ZnO nongrowth area. The selectivity is corroborated by both X-ray photoelectron spectroscopy (XPS) and low-energy ion scattering spectroscopy (LEIS).
View Article and Find Full Text PDFSensors (Basel)
February 2023
Department of Industrial Design, Eindhoven University of Technology, 5612 AZ Eindhoven, The Netherlands.
Cardiovascular diseases (CVD) represent a serious health problem worldwide, of which atrial fibrillation (AF) is one of the most common conditions. Early and timely diagnosis of CVD is essential for successful treatment. When implemented in the healthcare system this can ease the existing socio-economic burden on health institutions and government.
View Article and Find Full Text PDFLife (Basel)
January 2023
Research Engineering, Faculty of Health, Medicine, Life Sciences, Maastricht University, 6229 ER Maastricht, The Netherlands.
Background: In vivo diffuse reflectance spectroscopy provides additional contrast in discriminating nerves embedded in adipose tissue during surgery. However, large datasets are required to achieve clinically acceptable classification levels. This study assesses the spectral similarity between ex vivo porcine and in vivo human spectral data of nerve and adipose tissue, as porcine tissue could contribute to generate large datasets.
View Article and Find Full Text PDFSci Adv
February 2023
Molecular Materials and Nanosystems, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands.
Remote measurement of vital sign parameters like heartbeat and respiration rate represents a compelling challenge in monitoring an individual's health in a noninvasive way. This could be achieved by large field-of-view, easy-to-integrate unobtrusive sensors, such as large-area thin-film photodiodes. At long distances, however, discriminating weak light signals from background disturbance demands superior near-infrared (NIR) sensitivity and optical noise tolerance.
View Article and Find Full Text PDFFront Plant Sci
January 2023
School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.
Bi-directional-dual-flow-RootChip to track calcium signatures in primary roots responding to osmotic stress. Plant growth and survival is fundamentally linked with the ability to detect and respond to abiotic and biotic factors. Cytosolic free calcium (Ca) is a key messenger in signal transduction pathways associated with a variety of stresses, including mechanical, osmotic stress and the plants' innate immune system.
View Article and Find Full Text PDFAdv Mater
February 2023
Molecular Materials and Nanosystems and Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven, 5600 MB, The Netherlands.
Organic bulk heterojunction photodiodes (OPDs) attract attention for sensing and imaging. Their detectivity is typically limited by a substantial reverse bias dark current density (J ). Recently, using thermal admittance or spectral photocurrent measurements, J has been attributed to thermal charge generation mediated by mid-gap states.
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