Significance of perioperative intrasac pressure in sac shrinkage after endovascular abdominal aneurysm repair.

Background: Endovascular aneurysm repair (EVAR) results in a marked reduction of intrasac pressure, which is the likely cause of aneurysm sac shrinkage. We evaluated the change of intrasac pressure during operation and its association with aneurysm sac shrinkage one year after EVAR.

Methods: This study included 113 patients undergoing EVAR using the Gore C3 Excluder at our university hospital between March 2016 and December 2020.

Influence of Lower Limb Ischemia on Skeletal Muscle Mass Depletion in Patients with Peripheral Artery Disease.

Background: The aim of the study was to determine the change in skeletal muscle mass over time by bioelectrical impedance analysis (BIA) in patients with peripheral artery disease (PAD).

Methods: Patients with symptomatic PAD visiting Tokyo Medical University Hospital between January 2018 and October 2020 were retrospectively analyzed. PAD was diagnosed based on ankle brachial pressure index (ABI) < 0.

Rationalizing the Binding Modes of PET Radiotracers Targeting the Norepinephrine Transporter.

Purpose: A new PET radiotracer F-AF78 showing great potential for clinical application has been reported recently. It belongs to a new generation of phenethylguanidine-based norepinephrine transporter (NET)-targeting radiotracers. Although many efforts have been made to develop NET inhibitors as antidepressants, systemic investigations of the structure-activity relationships (SARs) of NET-targeting radiotracers have rarely been performed.

The Relationship between Mental and Physical Minor Health Complaints and the Intake of Dietary Nutrients.

Presenteeism is a problem that needs to be solved urgently, both for individual workers and for society overall. In this report, we propose the concept of MHC, which refers to mild mental and physical complaints subjectively perceived by individuals that are not caused by illness. We also planned to examine what kind of physical and mental disorder MHC is and whether food is effective as a method of self-care for MHC.

Observation and simulation of atmospheric gravity waves exciting subsequent tsunami along the coastline of Japan after Tonga explosion event.

Tsunamis are commonly generated by earthquakes beneath the ocean floor, volcanic eruptions, and landslides. The tsunami following the Tonga eruption of 2022 is believed to have been excited by atmospheric pressure fluctuations generated by the explosion of the volcano. The first, fast-traveling tsunami was excited by Lamb waves; however, it has not been clarified observationally or theoretically which type of atmospheric fluctuations excited more prominent tsunami which followd.

Dietary supplementation of deoxyribonucleic acid derived from chum salmon milt improves liver function in healthy Japanese individuals: a placebo-controlled, randomised, double-blind, parallel-group clinical trial.

A placebo-controlled, randomised, double-blind, parallel-group comparative study was conducted to investigate the effect of continuous intake of salmon milt (SM) DNA for 12 weeks on the improvement of liver function in 50 healthy Japanese participants aged 30 to 70 years with alanine aminotransferase (ALT) levels of 25-87 U L in men, 22-66 U L in women, of BMI 22.1-29.4 kg m.

The Impact of Purple-Flesh Potato ( L.) cv. "Shadow Queen" on Minor Health Complaints in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study.

The purple-flesh potato ( L.) cultivar "Shadow Queen" (SQ) naturally contains anthocyanins. This randomized, double-blind, placebo-controlled study determines whether ingesting purple potatoes increases the number of mesenchymal stem cells (MSC) and improves stress response, a minor health complaint in healthy adults (registration number: UMIN000038876).

Molecular Imaging-Derived Biomarker of Cardiac Nerve Integrity - Introducing High NET Affinity PET Probe F-AF78.

Radiolabeled agents that are substrates for the norepinephrine transporter (NET) can be used to quantify cardiac sympathetic nervous conditions and have been demonstrated to identify high-risk congestive heart failure (HF) patients prone to arrhythmic events. We aimed to fully characterize the kinetic profile of the novel F-labeled NET probe AF78 for PET imaging of the cardiac sympathetic nervous system (SNS) among various species. F-AF78 was compared to norepinephrine (NE) and established SNS radiotracers by employing cell assays, followed by an approach with healthy rats, rabbits and nonhuman primates (NHPs).

t-SNE Visualization of Vector Pairs of Similar and Dissimilar Definition Sentences Created by Word2vec and Doc2vec in Japanese Medical Device Adverse Event Terminology.

The purpose of our study is to identify the patterns of vectors in similar/dissimilar pairs of definition sentence created by Word2vec and doec2vec for elaboration of the terminology for Japanese Medical Device Adverse Events. 2-dimension vector space created by t-SNE showed that the pair with true positive located closer in a vector space, especially Doc2vec had a strong tendency. Comparing with Word2vec, Similar vectors in Doc2vec were close and tended to form clusters.

[Variation of the Implementation of PACS Functions and Image Data Management: Questionnaire Survey in Hokkaido Prefecture].

The image management function of picture archiving and communication system (PACS) plays a very important role while electronically preserving medical records. However, details of these mechanisms vary from manufacturer to manufacturer, which could be a problem if system specifications or image management functions are not confirmed by a user during system installation or operation. The purpose of this research was to record the differences in PACS settings and image data management in hospitals.

[A literature review on the relationship between questionnaires for assessing minor health complaints and health status indices among Japanese people].

Objectives　Minor health complaints related to stress, mental health, sleep, and fatigue are closely associated with each other, and their deterioration may cause lifestyle diseases. The health status of people can be predicted through a questionnaire by exploring the relationship between their state of minor health complaints and objective health status indices. Therefore, we conducted a systematic review of the relationship between a questionnaire on the state of minor health complaints and health status indices among Japanese people who have a high level of stress, which they experience on a daily basis, using epidemiological literature.

The combined effect of green tea and α-glucosyl hesperidin in preventing obesity: a randomized placebo-controlled clinical trial.

Green tea, a widely consumed beverage in Asia, contains green tea catechins effective against obesity, especially epigallocatechin-3-O-gallate (EGCG), but must be consumed in an impractically huge amount daily to elicit its biological effect. Meanwhile, citrus polyphenols have various physiological effects that could enhance EGCG functionality. Here we investigated the antiobesity effect of a combination of EGCG and α-glucosyl hesperidin, a citrus polyphenol, at doses that have not been previously reported to exert antiobesity effects by themselves in any clinical trial.

Effect of one-week administration of dipeptidyl peptidase-IV inhibitory peptides from chum salmon milt on postprandial blood glucose level: a randomised, placebo-controlled, double-blind, crossover, pilot clinical trial.

Salmon milt peptide (SMP), an unused fish processing byproduct, exhibits strong inhibitory activity against dipeptidyl peptidase-IV (DPP-IV) and a suppressive effect on postprandial hyperglycaemia in Sprague-Dawley rats. Herein, we conducted a randomised, placebo-controlled, double-blind, crossover study of healthy Japanese subjects to investigate the effect of glucose loading on postprandial blood glucose levels after one week of administering continuous or single dose of 500 mg of SMP. The primary and secondary outcomes of reduced blood glucose and insulin levels were not met in the 14 subjects included in the analysis.

The nightside cloud-top circulation of the atmosphere of Venus.

Although Venus is a terrestrial planet similar to Earth, its atmospheric circulation is much different and poorly characterized. Winds at the cloud top have been measured predominantly on the dayside. Prominent poleward drifts have been observed with dayside cloud tracking and interpreted to be caused by thermal tides and a Hadley circulation; however, the lack of nightside measurements over broad latitudes has prevented the unambiguous characterization of these components.

Screening of Fabry disease in patients with chronic kidney disease in Japan.

Background: Fabry disease (FD), an X-linked lysosomal storage disorder caused by a deficiency in alfa-galactosidase A (α-Gal A) activity due to mutations in the GLA gene, has a prevalence of 0-1.69% in patients undergoing haemodialysis; however, its prevalence in patients with chronic kidney disease (CKD) Stages 1-5 is unknown.

Methods: Serum α-Gal A activity analysis and direct sequencing of GLA were used to screen for FD in 2122 male patients with CKD, including 1703 patients with CKD Stage 5D and 419 with CKD Stages 1-5.

Narrative review of generative adversarial networks in medical and molecular imaging.

Recent years have witnessed a rapidly expanding use of artificial intelligence and machine learning in medical imaging. Generative adversarial networks (GANs) are techniques to synthesize images based on artificial neural networks and deep learning. In addition to the flexibility and versatility inherent in deep learning on which the GANs are based, the potential problem-solving ability of the GANs has attracted attention and is being vigorously studied in the medical and molecular imaging fields.

The Role of Micronutrients in Ageing Asia: What Can Be Implemented with the Existing Insights.

Life expectancy as a measure of population health does not reflect years of healthy life. The average life expectancy in the Asia-Pacific region has more than doubled since 1900 and is now above 70 years. In the Asia-Pacific region, the proportion of aged people in the population is expected to double between 2017 and 2050.

[18F]FDG-labelled stem cell PET imaging in different route of administrations and multiple animal species.

Stem cell therapy holds great promise for tissue regeneration and cancer treatment, although its efficacy is still inconclusive and requires further understanding and optimization of the procedures. Non-invasive cell tracking can provide an important opportunity to monitor in vivo cell distribution in living subjects. Here, using a combination of positron emission tomography (PET) and in vitro 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) direct cell labelling, the feasibility of engrafted stem cell monitoring was tested in multiple animal species.

Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice.

Overdose use of acetaminophen (APAP) often occurs a severe liver injury, and its liver injury is lethal in some cases. Macrophage migration inhibitory factor (MIF) is expressed in a variety of cells and has multifunctional roles. However, the role of MIF in APAP-induced liver injury has not been fully investigated.

Comparison of the Turn Switch Time Points Measured by Portable Force Platforms and Pressure Insoles.

Several methods to determine turn switch points during alpine skiing using the vertical GRF exist in the literature. Although comparative studies between pressure insoles (PI) and force platforms (FP) have been conducted, there are no reports comparing the detected time points. Yet, these sensors and methods have been used interchangeably.

Brightness modulations of our nearest terrestrial planet Venus reveal atmospheric super-rotation rather than surface features.

Terrestrial exoplanets orbiting within or near their host stars' habitable zone are potentially apt for life. It has been proposed that time-series measurements of reflected starlight from such planets will reveal their rotational period, main surface features and some atmospheric information. From imagery obtained with the Akatsuki spacecraft, here we show that Venus' brightness at 283, 365, and 2020 nm is modulated by one or both of two periods of 3.