114 results match your criteria: "Hokkaido Information University[Affiliation]"

Introduction: A simple risk stratification model to predict aneurysm sac shrinkagein patients undergoing endovascular aortic repair (EVAR) for abdominal aortic aneurysms (AAA) was developed using machine learning-based decision tree analysis.

Methods: One hundred nineteen patients with AAA who underwent elective EVAR at Tokyo Medical University Hospital between November 2013 and July 2019 were included in the study. Predictors of aneurysm sac shrinkage identified in univariable analysis (P < 0.

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Safety assessment of cyanoacrylate closure for treatment of varicose veins in a large-scale national survey in Japan.

J Vasc Surg Venous Lymphat Disord

December 2024

Department of Cardiovascular Surgery, Fukushima Dai-Ichi Hospital, Fukushima, Japan; Japanese Regulatory Committee for Endovascular Treatment of Varicose Veins, Tokyo, Japan.

Objective: Cyanoacrylate closure (CAC) is a minimally invasive technique for treating axial venous reflux. However, the incidence of serious adverse events (AEs) related to CAC is concerning. With an increasing number of patients undergoing CAC and insufficient safety data in Japan, this study aimed to investigate the safety profile of CAC, focusing on the types and incidence of AEs.

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Arterial stiffening is associated with adverse cardiovascular patient outcomes; stiffness may also be associated with postsurgical events and has been suggested to be a fundamental mechanism in the pathogenesis of aortic aneurysms. Although open repair of aneurysms decreases aortic stiffness, implantation of a rigid endograft is associated with increased aortic stiffness after endovascular aneurysm repair (EVAR). This review provides an overview of aortic wall physiology and the contemporary understanding of aortic stiffness and its implications for patients undergoing abdominal aortic aneurysm repair.

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Background: Endovascular aneurysm repair (EVAR) has revolutionized the treatment of abdominal aortic aneurysms by offering a less invasive alternative to open surgery. Understanding the factors that influence patient outcomes, particularly for high-risk patients, is crucial. The aim of this study was to determine whether machine learning (ML)-based decision tree analysis (DTA), a subset of artificial intelligence, could predict patient outcomes by identifying complex patterns in data.

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Background: Japanese dietary patterns have traditionally focused on vegetables, legumes, and fish; however, in the last few quarters of the century, the consumption of meat, processed food, and ultra-processed food has become popular. It is anticipated that these changes in the Japanese dietary environment will increase the risk of developing psychosomatic disorders.

Methods: In this study, we examined the relationship between dietary habits, psychosomatic disorders, and a sense of achievement.

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Article Synopsis
  • The study investigates the neutrophil-lymphocyte ratio (NLR) as a potential predictor for overall mortality in patients undergoing thoracic endovascular aortic repair (TEVAR) for degenerative thoracic aortic aneurysm (TAA).
  • Researchers analyzed data from 103 patients treated with TEVAR over nine years, finding that higher NLR, alongside age and ischemic heart disease, correlates with increased mortality risk.
  • The optimal NLR cutoff identified for predicting all-cause mortality was 3.48, indicating that elevated NLR can help identify patients at higher risk after the procedure.
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Purpose: This study aimed to evaluate a novel technique for cell tracking by visualising the activity of the human sodium/iodide symporter (hNIS) after transplantation of hNIS-expressing multilayered cell sheets in a rat model of chronic myocardial infarction.

Methods: Triple-layered cell sheets were generated from mouse embryonic fibroblasts (MEFs) derived from mice overexpressing hNIS (hNIS-Tg). Myocardial infarction was induced by permanent ligation of the left anterior descending coronary artery in F344 athymic rats, and a triple-layered MEFs sheets were transplanted to the infarcted area two weeks after surgery.

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Scallop oil (SCO) prepared from the internal organs of the Japanese giant scallop (Patinopecten yessoensis) contains eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and phospholipids (PL). It was previously shown that SCO consumption improves cholesterol and triacylglycerols (TG) contents in mice. The present study demonstrated the effects of daily SCO consumption (1.

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Objective: Heyndrickxia coagulans SANK70258, a representative probiotic, is known for alleviating inflammation caused by cedar pollen, improving the intestinal environment and bowel movements. A previous study on consuming H. coagulans SANK70258 together with galactooligosaccharides showed a trend toward improvement in skin scaliness scores and subjective assessments of skin roughness.

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Although promoting healthy eating is a policy objective, the manageability of dietary habits remains uncertain. Personal dietary patterns reflect many factors, some of which are relatively manageable for individuals whilst others are not. In this article, assuming that some sort of information about the manageability of dietary habits is contained in the observed patterns of food consumption, we focused on dietary patterns on their own.

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Diet has been repeatedly shown to affect mental and sleep health outcomes. However, it is well known that there are cross-cultural differences in dietary practices as well as the prevalence of mental and sleep health outcomes. Given that the dietary inflammatory potential of diets has been linked to mental and sleep health outcomes, in the current study we sought to assess the inflammatory status of habitual diets and examine its relationship with mental and sleep health outcomes in both the United Kingdom and Japan.

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[I]CLINDE SPECT as a neuroinflammation imaging approach in a rat model of stroke.

Exp Neurol

August 2024

Department of Investigative Radiology, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan; Faculty of Medicine, University of Turku, and Turku PET Centre, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland.

Poststroke neuroinflammation exacerbates disease progression. [C]PK11195-positron emission tomography (PET) imaging has been used to visualize neuroinflammation; however, its short half-life of 20 min limits its clinical use. [I]CLINDE has a longer half-life (13h); therefore, [I]CLINDE-single-photon emission computed tomography (SPECT) imaging is potentially more practical than [C]PK11195-PET imaging in clinical settings.

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In Japan, many workers are exposed to chronic stress, sleep deprivation, and nutritional imbalance. They tend still to go to work when ill, leading to decreased work performance and productivity, which has become a major social problem. We conducted a human entry study with the aim of finding a link between these two factors and proposing an optimized diet, believing that a review of diet may lead to an improvement in labor productivity.

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Article Synopsis
  • * The CAC-AE survey collected data from 1,030 authorized institutions, reporting 16 cases of proximal deep vein thrombosis, 3 cases of pulmonary embolism, and various other complications.
  • * The findings highlighted a total of 299 cases of localized phlebitis or allergic reactions, with one postoperative death linked to pulmonary embolism, aiming to present real-world data on CAC-related AEs in Japan.
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Background: Peripheral arterial disease (PAD) is associated with reduced muscle mass and quality, but the effects of leg ischemia caused by PAD on muscle quality remain poorly understood. The purpose of this study was to evaluate leg muscle mass and muscle quality in patients with intermittent claudication due to PAD using bioelectrical impedance analysis (BIA).

Methods: One hundred forty-one patients with intermittent claudication due to PAD who visited Tokyo Medical University Hospital from April 2019 to April 2020 were retrospectively analyzed.

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Dietary Inflammatory Index, Sleep Duration, and Sleep Quality: A Systematic Review.

Nutrients

March 2024

School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6ET, UK.

The inflammatory potential of the diet, as measured by the Dietary Inflammatory Index (DII), has been repeatedly shown to be associated with various inflammatory markers and mental and physical health outcomes. Of specific importance, several cross-sectional studies revealed mixed results regarding the correlations between the DII and sleep outcomes. Hence, in the current paper, a systematic review that examines the associations between the DII, sleep duration, and sleep quality was performed.

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An online health-monitoring system for COVID-19-infected patients who are staying in hotels and homes was developed using geographical information systems. This system provides display functions for sending health observation forms to infected residents, scoring for medical risk assessment, and centralized management. More than 1,146,000 health observation records were registered in November 2022, and the system contributed to maintaining the functionality of the municipal health center in Sapporo, Japan.

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The purpose of this study was to evaluate the accuracy of deep neural machine translation focused on medical device adverse event terminology. 10 models were obtained, and their English-to-Japanese translation accuracy was evaluated using quantitative and qualitative measures. No significant difference was found in the quantitative index except for a few pairs.

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Human adenovirus oncolytic properties and the inhibitory role of E4 orf4 and E4 orf6/7 on endogenously activated NF-κB.

Biochem Biophys Rep

March 2024

Department of Oral Molecular Microbiology, Division of Oral Pathobiological Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Japan.

Article Synopsis
  • Human adenovirus is being studied as a potential cancer treatment and the E4 gene's role in this therapy is being investigated.
  • The E4 proteins, particularly E4 orf4 and E4 orf6/7, have been found to inhibit NF-κB activation, which is crucial for immune responses and cancer progression.
  • The findings suggest that these E4 proteins might not only suppress NF-κB but could also enhance the anticancer effects of the adenovirus by regulating E1A expression during the later stages of infection.
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Article Synopsis
  • - The study investigated how yeast mannan (YM) affects gut health and sleep quality in 40 healthy adults with defecation issues over four weeks, using a placebo for comparison.
  • - Results showed the YM group experienced more frequent and larger bowel movements, along with improved sleep metrics, specifically longer non-REM sleep stage 3 (N3) and shorter latency to enter this sleep stage.
  • - Metabolomics analysis revealed significant differences in 20 metabolites between the groups, with fecal propionate and GABA levels being key factors linked to the improvements in total time in bed and sleep latency, respectively.
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Purpose: The purpose of this study was to assess inter-rater reliability and workload for creating accurate training data in the clinical evaluation of mammographic positioning for deep learning.

Methods: A total of 107 mammographic images without lesions were labeled by two certified radiologic technologists in seven items: six clinical image evaluation criteria in positioning and breast tissue density. The kappa coefficient was calculated as an indicator of interrater reliability.

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Bifidobacterium animalis subsp. lactis GCL2505 (GCL2505) improves the intestinal microbiota and reduces human visceral fat. This randomized, double-blind, placebo-controlled, parallel-group study was conducted to examine the effects of inulin, a prebiotic dietary fiber, and GCL2505 on vascular endothelial function in healthy subjects (n = 60).

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Purpose: The purpose of this study was to investigate the preoperative lymphocyte-to-monocyte ratio (LMR) as a potential surrogate biomarker predictive of overall mortality in patients undergoing endovascular aortic repair (EVAR) for abdominal aortic aneurysm (AAA).

Methods: Data on patients with AAA treated by EVAR between March 2012 and December 2016 were obtained from a prospectively maintained EVAR database at Tokyo Medical University Hospital, Tokyo, Japan. The LMR was calculated by dividing the absolute lymphocyte count by the absolute monocyte count.

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Depression in later life is associated with dementia. Changes in motivated behavior are an important mechanism contributing to dysfunctional cognitive control in depression. Although continuous intake of quercetin-rich onion suppresses cognitive decline in aged people by improving their emotional condition, the effect of quercetin-rich onion on emotional condition in people living with cognitive impairment remains unclear.

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The relationship between nutritional status and morbidity and death in a number of diseases and disorders has garnered considerable attension. In patients having endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA), we assessed the prognostic value of nutritional markers of albumin (ALB), body mass index (BMI), and geriatric nutritional risk index (GNRI) for long-term mortality. Retrospective data analysis was done on patients who had undergone elective EVAR for AAA more than 5 years earlier.

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