17 results match your criteria: "Hofu Institute of Gastroenterology.[Affiliation]"

Exploratory study on the impact of intraesophageal pressure on quality of life in patients following total gastrectomy: a retrospective cohort study.

BMC Surg

July 2024

Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Science, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.

Article Synopsis
  • - The study investigated how intraesophageal pressure impacts quality of life in patients who had total gastrectomy with Roux-en-Y anastomosis, using high-resolution impedance manometry (HRIM) on 12 participants post-surgery.
  • - Most patients exhibited normal esophageal motility, and factors like integrated relaxation pressure and lower esophageal sphincter residual pressure correlated with specific symptoms, such as diarrhea and indigestion.
  • - The findings suggest that HRIM is a valuable tool for assessing esophageal function and its effects on quality of life following total gastrectomy.
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Article Synopsis
  • This study evaluates the functional outcomes of esophagogastric anastomosis in patients who had proximal gastrectomy using the hinged double flap method for gastric cancer, focusing on high-resolution impedance manometry (HRIM).
  • Researchers analyzed data from 25 patients post-surgery, retrieving questionnaires from 16 participants to assess post-surgery symptoms through the Postgastrectomy Syndrome Assessment Scale-37 (PGSAS-37).
  • Findings indicated that while some HRIM measurements were normal, many patients experienced high lower esophageal sphincter (LES) residual pressure during swallowing, which was linked to worsening reflux and diarrhea symptoms post-surgery.
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Establishment of a novel overlay culture method that enables immune response assessment using gastric cancer organoids.

Heliyon

January 2024

Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical & Health Science, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima, 734-8551, Japan.

Article Synopsis
  • Organoid technology is a new 3D cell culture system that can mimic a patient's cancer, offering a potential model for immunotherapy, but lacks effective gastric cancer organoid (GCO) models that allow immune cell interaction.
  • This study developed a coculture model using Matrigel where immune cells can move freely and interact with GCOs, preserving the organoid's 3D structure and cancer characteristics.
  • The new model allows for real-time observation of immune responses and tumor destruction, enabling the evaluation of immune cell effectiveness and the potential prediction of immune checkpoint inhibitor responses in patients.
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Article Synopsis
  • Epstein-Barr-virus-associated gastric cancer (EBVaGC) accounts for about 7% of all gastric cancers and is characterized by significant DNA hypermethylation and rich tumor-infiltrating lymphocytes.
  • In its early stages, EBVaGC has low lymph-node metastasis and a relatively positive outlook in later stages, typically appearing as a depressed mass during endoscopic examinations.
  • There is a need for better endoscopic diagnostic techniques as current recognition rates are only 21.4%, and expanding endoscopic submucosal dissection (ESD) criteria may assist in treating early cases with minimal lymph-node spread.
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The involvement of circulating CD69+ CD56bright natural killer cells in weight loss before bariatric surgery: A retrospective cohort study.

Medicine (Baltimore)

October 2023

Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan.

Article Synopsis
  • - The study explored how the immune system may serve as a predictor for preoperative weight loss in obese patients undergoing bariatric surgery, involving 34 participants and examining various clinical and biochemical data.
  • - Findings indicated that certain immune markers, such as lymphocyte count and C-reactive protein (CRP) levels, showed negative correlations with both preoperative excess weight loss and total weight loss, suggesting a link between immune response and weight loss outcomes.
  • - Notably, there was a significant difference in a specific immune cell activation marker (CD69) between patients with high and low preoperative weight loss, indicating that immune system factors, particularly those related to systemic inflammation, could impact weight loss success prior to surgery.
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In Japan, China, and Singapore, several studies have reported increased incidences of peripheral venous catheter-related bloodstream infection by during the summer. Therefore, we hypothesized that bed bathing with a -contaminated "clean" towels increases contact with the catheter and increases the odds of contaminating the peripheral parenteral nutrition (PPN). We found that 1) professionally laundered "clean" towels used in hospitals have (3.

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A low prognostic nutritional index is associated with increased remote infections within 30 days of colorectal surgery: A retrospective cohort study.

Am J Infect Control

November 2023

Pharmacy Department, Yamaguchi University Hospital, Ube, Yamaguchi, Japan; Clinical Pharmacology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan. Electronic address:

Objective: This study aimed to identify risk factors for remote infection (RI) within 30 days after colorectal surgery.

Methods: This retrospective study included 660 patients who underwent colorectal surgery at Yamaguchi University Hospital or Ube Kosan Central Hospital between April 2015 and March 2019. Using electronic medical records, we identified the incidence of surgical site infection and RI within 30 days after surgery and obtained information on associated factors.

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Background And Study Aims: The diagnostic ability of endoscopists to determine invasion depth of early gastric cancer is not favorable. We designed an artificial intelligence (AI) classifier for differentiating intramucosal and submucosal gastric cancers and examined it to establish a diagnostic method based on cooperation between AI and endoscopists.

Patients And Methods: We prepared 500 training images using cases of mainly depressed-type early gastric cancer from 250 intramucosal cancers and 250 submucosal cancers.

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Background: Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is classified as one of the molecular subtypes of gastric cancer. We used droplet digital polymerase chain reaction (ddPCR) to enable highly sensitive and quantitative detection of EBV.

Methods: EBV-DNA load was calculated based on the copy number of the BamH1-W fragment of EBV by ddPCR, and the cut-off value of EBV-DNA load was set.

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Epstein-Barr virus (EBV) is a ubiquitous human herpes virus, but related with several types of malignancies. Among EBV-related malignancies, EBV-associated gastric carcinoma (EBVaGC) has the largest patient's number. We screened for EBV infection in 1067 GC lesions of 1132 patients who underwent surgical resection from 2007 to 2017 in Japan and examined clinicopathological features of EBVaGC.

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A 69-year-old man, who had undergone pylorus-preserving pancreaticoduodenectomy (PD) (Imanaga procedure) for duodenum papilla cancer 13 years prior, had a history of repeated hospitalization due to cholangitis since the third year after surgery and liver abscess at the 10th year after surgery. Gastrointestinal series indicated no stenosis after the cholangiojejunostomy. However, reflux of contrast media into the bile duct and persistence of food residues were observed.

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We report the case of a 64-year-old man who underwent resection on two occasions for recurrent renal cell carcinoma. He first underwent right nephrectomy for renal cell carcinoma, and 10 years later, he underwent pylorus-preserving pancreaticoduodenectomy for pancreatic metastasis. Microscopic extracapsular invasion without lymph node metastasis was observed at that time.

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Background: We have actively carried out cell-free and concentrated ascites reinfusion therapy (CART) for refractory ascites. However, with conventional CART, the membrane becomes clogged after processing about 2 L of cancerous ascites fluid due to the fact that it is rich in cellular and mucous components; it is therefore difficult to process the entire volume of collected ascites.

Methods: We developed KM-CART which includes a membrane cleaning function, and applied it in 73 cases of cancerous ascites, after its basic functions had been evaluated in 11 cases of refractory cancerous ascites.

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A 78-year-old woman underwent gastrectomy for type 3 gastric cancer with pyloric stenosis, which was detected in November 1997. Thoracic and abdominal CT and other diagnostic procedures were conducted regularly for 5 years after surgery. The patient was recurrence-free and her clinical course was satisfactory.

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A 79-year-old female who was surgically treated and received adjuvant chemotherapy for primary non-Hodgkin's lymphoma of the descending colon with massive extension into the pancreatic tail, spleen, and left kidney is herein reported. The patient had acute colonic obstruction and an urgent laparotomy was performed because endoscopic decompression using a transnasal ileus tube could not be done. We performed a left colectomy with an en bloc resection of the neighboring organs, followed by the creation of an end colostomy.

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Arteriovenous malformation of the pancreas is a rare condition that may cause upper gastrointestinal bleeding. A 58-year-old man with an arteriovenous malformation of the pancreas is described. The patient had recurrent episodes of melena.

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