5 results match your criteria: "Hofstra North Shore-Long Island Jewish Medical School[Affiliation]"
Impact of APOL1 polymorphism and IL-1β priming in the entry and persistence of HIV-1 in human podocytes.
Retrovirology
September 2016
Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
Background: Patients of African ancestry with untreated HIV-1 infection and carrying the G1 or G2 kidney disease risk variants (Vs) at the APOL1 gene have a tenfold higher risk of developing HIV-associated nephropathy (HIVAN) compared to those with the non-risk wild type (WT) G0 variant. However, the mechanistic contribution of the APOL1 allelic state to kidney injury in HIV-1 infection remains to be elucidated.
Results: Non-risk WT APOL1 is associated with lower intracellular levels of HIV-1 in conditionally immortalized human podocytes, while the over expression of G1 or G2 risk Vs significantly increases viral accumulation.
HIV Promotes NLRP3 Inflammasome Complex Activation in Murine HIV-Associated Nephropathy.
Am J Pathol
February 2016
Renal Molecular Research Laboratory, Feinstein Institute for Medical Research, Hofstra North Shore Long Island Jewish Medical School, New York, New York. Electronic address:
Dysregulated growth and loss of podocytes are important features of HIV-associated nephropathy. Recently, HIV was reported to induce a new type of programed cell death, pyroptosis, in T lymphocytes through induction of Nod-like receptor protein 3 (NLRP3) inflammasome complexes. We evaluated the role of HIV in podocyte NLRP3 inflammasome formation both in vivo and in vitro.
View Article and Find Full Text PDFFull-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes.
Sci Rep
September 2015
Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
Article Synopsis
- Increased levels of soluble urokinase-type plasminogen activator receptor (suPAR) are linked to focal segmental glomerulosclerosis and other kidney-related diseases, including HIV and diabetes.
- Full-length suPAR reduces nephrin expression in human podocytes, impacting kidney function and is dependent on time and dosage as well as the inhibition of the WT-1 transcription factor.
- Studies in a mouse model reveal that suPAR causes decreased nephrin and WT-1 expression, leading to proteinuria, highlighting its role in kidney diseases with elevated suPAR levels.
Torsion of the appendix testis in an undescended testis: a case report.
Can J Urol
June 2013
Division of Pediatric Urology, Cohen Children's Medical Center of New York, Hofstra North Shore-Long Island Jewish Medical School, Lake Success, NY 11042, USA.
We present the first case of torsion of an appendix testis in a cryptorchid testicle. The difficulties in history, physical examination and imaging posed by such a presentation are presented as well as management considerations.
View Article and Find Full Text PDFTubular cell HIV-entry through apoptosed CD4 T cells: a novel pathway.
Virology
December 2012
Center for Excellence for Immunology and Inflammation, Feinstein Institute for Medical Research, Hofstra North Shore Long Island Jewish Medical School, New Hyde Park, NY, USA.
We hypothesized that HIV-1 may enter tubular cells by phagocytosis of apoptotic fragments of HIV-1-infected T cells infiltrating tubular interstitium. The study was designed to evaluate the interaction of programmed death-1 (PD-1) receptors on CD4 T cells and programmed death ligand-1 (PD-L1) on tubular cells (HK2 and HRPTEC, primary tubular cells). Co-cultivation of HIV-1 infected lymphocytes (HIV-LY) with HK2s/HRPTECs resulted in T cell apoptosis, uptake of the apoptosed HIV-LY by HK2s/HRPTECs, tubular cell activation and HIV expression.
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