8,174 results match your criteria: "Histoplasmosis"
Pediatr Infect Dis J
December 2024
Division of Pediatrics Infectious Diseases, Department of Pediatrics, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.
Cureus
November 2024
Department of Dermatology, University of Nebraska Medical Center, Omaha, USA.
is a dimorphic fungus that causes pulmonary, disseminated, or, rarely, primary cutaneous disease. Primary cutaneous histoplasmosis presents with non-specific skin lesions, which can lead to poor patient outcomes due to diagnostic challenges and delays in diagnosis. A 62-year-old male on immunosuppressive medications for lupus nephritis presented to the emergency department with 24 hours of altered mental status.
View Article and Find Full Text PDFInfect Dis Clin North Am
December 2024
Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, ECMM Excellence Center, Auenbruggerplatz 15, Graz 8036, Austria; Translational Mycology, Medical University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria. Electronic address:
This review explores how climate change influences fungal disease dynamics, focusing on emergence of new fungal pathogens, increased antifungal resistance, expanding geographic ranges of fungal pathogens, and heightened host susceptibility. Rising temperatures and altered precipitation patterns enhance fungal growth and resistance mechanisms, complicating treatment efforts. Climate-driven geographic shifts are expanding the range of diseases like Valley fever, histoplasmosis, and blastomycosis.
View Article and Find Full Text PDFInfect Dis Clin North Am
December 2024
Department of Medicine, Division of Infectious Disease, Johns Hopkins University School of Medicine, Boston, MA, USA; Division of Infectious Diseases, Transplant and Oncology Infectious Diseases, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
This review provides an update of histoplasmosis, covering the changing epidemiology, pathogenesis, disease manifestations, diagnostic strategies, and management considerations for immunocompetent and immunocompromised populations.
View Article and Find Full Text PDFMed Mycol
December 2024
Unidad micología Hosp Enfermedades infecciosas F.J Muñiz, CABA, Argentina.
Histoplasmosis poses a significant risk to HIV patients, particularly in regions with limited access to antiretroviral therapy. Antigen detection assays are crucial in these settings for timely diagnosis and treatment, which can reduce mortality. While commercial antigen detection kits have performed well in diagnosing histoplasmosis, their effectiveness in monitoring treatment remains unclear.
View Article and Find Full Text PDFFront Immunol
December 2024
Department of Internal Medicine I, Saarland University Medical School, Homburg/Saar, Germany.
We report here on a patient with concomitant indolent lymphoma who showed a rapid progressive deterioration of his general condition and emerging neurological symptoms. The combination of severe B symptoms with hypermetabolic involvement of the adrenal glands and multiple central nervous system (CNS) lesions initially suggested a malignant disease. However, when the patient presented to us with biopsy results from one of the CNS lesions, the biopsy revealed granulomatous inflammation but no evidence of malignancy.
View Article and Find Full Text PDFTranspl Infect Dis
December 2024
Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Background: Histoplasmosis is an important infection among transplant recipients. Few studies have described its epidemiology and outcomes in the modern era.
Methods: We conducted a retrospective analysis using medical records from a single center in the United States.
IDCases
November 2024
Rutgers Robert Wood Johnson Medical School, Division of Infectious Diseases, New Brunswick, NJ, United States.
Oral manifestations of disseminated histoplasmosis are rare but can present in immunocompromised individuals. We report a case of disseminated Histoplasmosis presenting with presumed oral involvement and pneumonia in a seropositive HIV individual. A 32-year-old male with HIV presented to the emergency department for a two-week history of abdominal pain and a tongue ulcer in the setting of significant weight loss, blood-tinged sputum, and non-adherence with antiretroviral therapy for three years.
View Article and Find Full Text PDFOpen Forum Infect Dis
December 2024
Associate Professor of Medicine, Department of Infectious Disease at the University of Rochester, Rochester, New York, USA.
is a pathogenic dimorphic fungus with evolving epidemiology. Initially described as endemic to the Ohio and Mississippi river valleys, the infection now regularly occurs in central and eastern United States, with cases reported across the entire country. Transmission happens via inhalation of conidia during activities that disturb fungal hyphae.
View Article and Find Full Text PDFIndian J Dermatol
October 2024
Department of Dermatology, Institute of Child Health, Kolkata, India.
Introduction: Deep mycoses acquired by penetrating trauma to the skin can have varied and sometimes atypical morphological presentations resulting in diagnostic dilemmas and delay in treatment onset. Histopathology can be a useful tool in not only diagnosing but also differentiating various deep mycoses.
Aims And Objectives: To observe various morphological presentations and histopathological features of deep fungal infections.
Curr Probl Diagn Radiol
December 2024
Department of Radiology, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.
The diagnostic algorithm for histoplasmosis highlights the importance of imaging and emphasizes the role of the radiologist in the diagnostic workup. Here we describe a case series of patients with a novel sign of lung involvement in histoplasmosis which we have coined the Pseudo-Pulmonary Arteriovenous Malformation (PAVM) sign, the usage of which would help in the imaging diagnosis of histoplasmosis aid by distinguishing it from PAVMs. PAVMs carry risk for serious complications such as systemic emboli and may require treatment; whereas, histoplasmomas do not.
View Article and Find Full Text PDFInt J Infect Dis
December 2024
Centre d'Investigation Clinique Antilles Guyane Inserm CIC1424, Centre Hospitalier de Cayenne, Cayenne, French Guiana; DFR Santé, Université de Guyane, Cayenne, French Guiana; CRB Amazonie, Centre Hospitalier de Cayenne, Cayenne, French Guiana.
Background: Diagnosis of HIV-associated histoplasmosis remains challenging. Our objective was to compare the performances of (1→3)-β-D-Glucan (BDG) and Aspergillus galactomannan (GM) antigen for the diagnosis of HIV-associated histoplasmosis.
Methods: We performed a diagnostic accuracy study using frozen primary serum specimens issued from consecutive hospitalized people living with HIV (PLWH) and blindly tested for BDG and GM using Fungitell® and PlateliaTM Aspergillus, respectively.
Breathe (Sheff)
October 2024
Respiratory Department, St James' Hospital, Dublin, Ireland.
https://bit.ly/4dXUOX4.
View Article and Find Full Text PDFJ Antimicrob Chemother
December 2024
Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, 4523 Clayton Ave, MSC 8051-0043-15, St. Louis, MO 63110, USA.
Background: Itraconazole is the treatment of choice for many fungal infections, including histoplasmosis. While the tolerability of itraconazole has been described in short-term trial settings, there are few studies on side effects during long-term therapy. Fluconazole, which is usually thought to be less toxic, is associated with 52% toxicity in long-term treatment.
View Article and Find Full Text PDFVirulence
December 2024
Department of Microbiology, Ohio State University, Columbus, OH, USA.
Clin Microbiol Infect
December 2024
Institut Pasteur, Université Paris Cité, Centre National de Référence Mycoses Invasives et Antifongiques, Groupe de recherche Mycologie Translationnelle, Département de Mycologie, F-75015 Paris, France; Laboratoire de parasitologie-mycologie, AP-HP, Hôpital Saint-Louis, F-75010 Paris, France. Electronic address:
Objectives: Disseminated histoplasmosis (DH) is a lethal fungal disease in patients living with HIV in endemic regions of the world. Diagnosis relies mainly on microscopy, culture and antigen detection. Our goal was to evaluate the diagnostic and prognostic role of our reverse transcriptase quantitative PCR (RTqPCR) in blood specimens allowing to quantify the whole nucleic acids (WNA) load.
View Article and Find Full Text PDFBMC Infect Dis
December 2024
Division of Infectious Diseases, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
PLoS One
November 2024
Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil.
The rapid diagnosis of opportunistic infections (OIs) is critical for improving the health outcomes of people living with HIV/AIDS (PLWHA). This study aimed to describe the feasibility of implementing a package for the rapid diagnosis of tuberculosis, histoplasmosis, and cryptococcosis in patients with advanced HIV/AIDS disease in Porto Alegre, Brazil. The research involved two focus groups with health professionals, four in-depth interviews with healthcare managers, and twelve interviews with PLWHA.
View Article and Find Full Text PDFAntibiotics (Basel)
October 2024
Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A., Pereira 660003, Colombia.
J Fungi (Basel)
October 2024
Division of Infectious Diseases, Department of Medicine, The University of Arizona College of Medicine, Tucson, AZ 85724, USA.
In this review, we present a case report of an immunocompetent 58-year-old male who presented with disseminated histoplasmosis (DH) outside of the known endemic regions. Due to his atypical clinical presentation that did not fit the classical clinical picture of DH, the diagnosis was delayed. In addition, we researched DH in the immunocompetent hosts as these cases are not common and leave the patient population vulnerable to delayed diagnosis.
View Article and Find Full Text PDFAm J Dermatopathol
December 2024
Department of Pathology, All India Institute of Medical Sciences, Jodhpur, India.
Indian J Otolaryngol Head Neck Surg
December 2024
Department of Otolaryngology Head Neck Surgery, LSU Health Shreveport, 1501 Kings' Hwy, Shreveport, 71103 LA USA.
BMC Infect Dis
November 2024
Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, India.
Indian J Med Microbiol
December 2024
Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar, 751019, India. Electronic address: