Neutralizing effects of an anti-vascular endothelial growth factor antibody on tooth movement.

Our recent studies demonstrated that local administration of recombinant human vascular endothelial growth factor (rhVEGF) during experimental tooth movement enhanced the number of osteoclasts and the rate of tooth movement. The purpose of this study was to examine the effect of anti-VEGF polyclonal antibody on osteoclastic differentiation, the amount of tooth movement, and the degree of tooth relapse in 30-day-old mice. First, these mice were subjected to various doses of anti-VEGF polyclonal antibody, with tooth movement for three days.

[Relationship between estrogen-receptor genotype and tooth loss in postmenopausal women].

Tooth loss is known to be influenced by environmental factors, but the role of genetic factors remains unknown. It is likely that the estrogen-receptor (ER) gene could be associated with tooth loss in women because recent studies in the United State reported the protective effect of estrogen replacement therapy on tooth retention in the elderly. We first demonstrated relationship between ER genotype and tooth loss in post-menopausal women.

[Association between bone mineral density of the general skeletons and jaw bones].

Associations between bone mineral density (BMD) of the general skeletons and jaw bones have been investigated to clarify the influences of skeletal low BMD or osteoporosis on periodontitis and tooth loss, especially in women. Some studies reported the significant associations between general skeletal BMD and BMD (or bone mass) of the jaw bones, however, the others failed to find this association. It is likely that the differences in the methods and regions in measuring BMD (or bone mass) of the jaw bones and in study sample size may contribute to this contradiction.

Effect of estrogen use on tooth retention, oral bone height, and oral bone porosity in Japanese postmenopausal women.

Objective: Recent studies in the United States support the protective effect of estrogen use on tooth retention; however, little is known as to how estrogen promotes tooth retention. The aims of this study were to investigate the effects of estrogen use on tooth retention, oral bone height, and oral bone porosity in Japanese postmenopausal women and to clarify how estrogen promotes tooth retention.

Design: Relationships among the number of teeth remaining (total, anterior, and posterior teeth), oral bone height, oral bone porosity, bone mineral density of the lumbar spine and the femoral neck, estrogen use status, and the duration of estrogen use were evaluated in 330 Japanese postmenopausal women (mean age +/- SD, 56.

Recommendation of modified classification for odontogenic carcinomas.

Primary squamous cell carcinoma (SCC) derived from odontogenic epithelium is diagnosed as primary intraosseous carcinoma (PIOC). The term "intraosseous" means the bone marrow spaces. Odontogenic cells, however, exist not only in the bone marrow space but also in the periodontal space and the subepithelial soft tissue space.

Dedifferentiated malignant myoepithelioma of the parotid gland.

Dedifferentiated salivary gland tumor is a rare, recently recognized tumor type. A case of dedifferentiated malignant myoepithelioma in a 59-year-old man who presented with a painful mass in the left preauricular region is reported. Histologically, two distinct neoplastic cell populations were observed in the same tumor mass.

Detection of vascular disease risk in women by panoramic radiography.

Low bone mineral density and rapid bone loss of the skeleton are associated with mortality risk from vascular diseases in post-menopausal women. Panoramic radiographic measurements are considered as indicators of skeletal bone mineral density or bone turnover. We hypothesize that such measurements may be associated with vascular disease risk in post-menopausal women.

Relationship between dental panoramic radiographic findings and biochemical markers of bone turnover.

Unlabelled: We investigated whether mandibular cortical measures on dental panoramic radiographs are associated with biochemical markers of bone turnover in 82 postmenopausal women. Mandibular cortical shape was significantly associated with biochemical markers and spinal BMD. Our results suggest that dentists may be able to identify postmenopausal women with low BMD by using dental panoramic radiographs.

Diagnostic points and possible origin of osteomyelitis in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome: a radiographic study of 77 mandibular osteomyelitis cases.

Objectives: To find diagnostic points and to identify the origin of osteomyelitis in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome.

Methods: Fifty-two patients with mandibular suppurative osteomyelitis and 25 patients with mandibular osteomyelitis in SAPHO syndrome were included in the study. Radiographic patterns of the lesion, types of periosteal reaction and the presence of external bone resorption and bone enlargement were investigated in each case and compared between the two entities.

Association of estrogen and vitamin D receptor gene polymorphisms with tooth loss and oral bone loss in Japanese postmenopausal women.

Objective: To investigate the relationship between estrogen receptor (ER) and vitamin D receptor (VDR) gene polymorphisms and tooth loss, oral bone loss, and postcranial bone mineral density (BMD) in Japanese postmenopausal women.

Design: Polymorphisms at the ER PvuII and XbaI and VDR BsmI gene sites, number of teeth remaining, oral bone mass, and BMD of the lumbar spine and the hip were evaluated in 149 Japanese postmenopausal women.

Results: The distribution of ER PvuII and XbaI and VDR BsmI restriction fragment length polymorphisms was as follows: pp, 30.

Clinical recovery time from conscious sedation for dental outpatients.

For dental outpatients undergoing conscious sedation, recovery from sedation must be sufficient to allow safe discharge home, and many researchers have defined "recovery time" as the time until the patient was permitted to return home after the end of dental treatment. But it is frequently observed that patients remain in the clinic after receiving permission to go home. The present study investigated "clinical recovery time," which is defined as the time until discharge from the clinic after a dental procedure.

Solitary fibrous tumor with malignant potential arising in sublingual gland.

A rare case is described of a solitary fibrous tumor (SFT) with malignant potential arising in the sublingual gland. A 59-year-old man presented with a 4-month history of a slowly enlarging painless mass in the center of the floor of the mouth. The tumor was a well-demarcated, firm mass with a multicystic lesion.

Pleomorphic adenoma with extensive adenoid cystic carcinoma-like cribriform areas of parotid gland.

We report an interesting case of pleomorphic adenoma (PA) with extensive adenoid cystic carcinoma (ACC)-like cribriform areas of parotid gland along with a discussion of the differential diagnosis. The patient was a 62-year-old-female who presented with a 5-month history of a slow-growing painless mass in the left preauricular region. Pathological examination of the excised mass revealed a well-encapsulated tumor consisting of typical PA areas and extensive ACC-like cribriform areas.

An adult case of skeletal open bite with a severely narrowed maxillary dental arch.

Surgically assisted rapid maxillary expansion is proposed as an efficient approach for adult patients with transverse maxillary deficiency. This article reports the treatment of an 18-year, seven-month old male patient with an anterior open bite and a severely narrowed upper dental arch. A posterior crossbite was present on both sides.

Biologic responses of the pulp to single-tooth dento-osseous osteotomy.

Objective: This study was conducted to investigate biologic responses of the pulp to single-tooth dento-osseous osteotomy and to explore an appropriate level of transverse bone resection for maintaining biologic activity of the pulp in monkeys.

Study Design: The levels of transverse bone resection were designed at approximately 10 mm (10 mm group) and 5 mm (5 mm group) above the apices. Histologic and histomorphometric changes were evaluated microscopically, and changes in blood flow in the pulp were also measured in terms of vascular responses to a vasoconstrictor (noradrenaline, NA).

Halothane-induced cytotoxicity in isolated rat hepatocytes: an electron microscopic study.

To determine the direct cytotoxicity of halothane for liver cells, the effects of this agent on isolated rat hepatocytes were investigated by electron microscopy and by examining cell viability. Soon after treatment with lower concentrations of halothane (0.5% and 0.

Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI).

Thirteen examples of pleomorphic adenoma (PA) and 4 of myoepithelioma (Me, 2 plasmacytoid cell type, 2 mixed cell type) were examined with respect to their proliferative activity on the basis of proliferating cell nuclear antigen (PCNA) immunohistochemistry. In PA, PCNA labeling index (LI) in tubular/trabecular/solid areas was significantly higher than that in myxomatous or chondroid areas. Although the mean value of LI in PA and Me was not statistically different (PA; 3.

Leakage of mitochondrial and cytosolic GOT in isolated rat hepatocytes exposed to halothane: an immunohistochemical study.

The leakage of mitochondrial (m-) and cytosolic (s-) aspartate aminotransferases (glutamic-oxaloacetic transaminase: GOT) from isolated hepatocytes exposed to halothane was investigated immunohistochemically. In control isolated hepatocytes, a large number of cells were immunopositive (m-GOT, 85%; s-GOT, 98.5%) at various intensities.

Clear cell tumors of minor salivary gland origin. An immunohistochemical and ultrastructural analysis.

Three cases of monophasic glycogen-rich clear cell tumors of palatal gland origin were examined immunohistochemically and ultrastructurally in attempts to characterize their cellular composition. Despite their histologic resemblances, the clear cells from each case showed different immunohistochemical features. In case 1 the extensive positivity for vimentin and S-100 protein, in addition to the focal expression of actin and glial fibrillary acidic protein, strongly suggested that the clear cells were myoepithelial in nature.

Effect of calcium channel blocking agents on the reductive metabolism of halothane.

The effect of calcium channel blocking agents on the reductive metabolism of halothane in liver microsomes of guinea pigs was investigated. The reaction mixture for the measurement of the end products consisted of microsomal suspension, 5 mM NADPH, calcium channel blocking agents (verapamil, diltiazem, nicardipine and nifedipine) and halothane in 0.1 M phosphate buffer (pH 7.

The cellular composition of basal cell adenoma of the parotid gland: an immunohistochemical analysis.

Four cases of basal cell adenoma of the parotid gland were examined immunohistochemically to characterize their cellular composition. In all cases epithelial membrane antigen and keratin were detected in the inner luminal cells; some cells also showed positive staining for secretory functional markers, indicating their differentiation toward secretory epithelium. In tubular and trabecular types the outer cells consistently displayed an intense staining for vimentin and some were also positive for actin, indicating their myoepithelial nature.

Evaluation of the accuracy of non-invasive automatic blood pressure monitors.

Non-invasive automatic blood pressure monitors (BP-103N, DINAMAP 845XT, Finapres 2300) were compared with the auscultatory method. The blood pressure readings given by the oscillometric method (BP-103N, DINAMAP 845XT) were accurate and reproducible. Agreement with the auscultatory method was especially good for systolic pressure.

The effects of vasoactive drugs on halothane inhibition of contractions of rat mesenteric lymphatics.

The effects of halothane on alpha-adrenergic receptors, beta-adrenergic receptors, and the process of Ca++ dependent contractions on rat mesenteric lymphatics were examined. Halothane depressed the contraction rate of mesenteric lymphatics but did not effect the increase in lymphatic contraction rate caused by noradrenaline (an alpha-agonist). The depressant effect of halothane on the contraction rate was also not antagonized by propranolol (a beta-blocker), but was partly reversed by CaCl2.